ATE174800T1 - Dendrimere polychelate - Google Patents

Dendrimere polychelate

Info

Publication number
ATE174800T1
ATE174800T1 AT92920822T AT92920822T ATE174800T1 AT E174800 T1 ATE174800 T1 AT E174800T1 AT 92920822 T AT92920822 T AT 92920822T AT 92920822 T AT92920822 T AT 92920822T AT E174800 T1 ATE174800 T1 AT E174800T1
Authority
AT
Austria
Prior art keywords
polychelate
conjugated
site
dendrimere
macrocyclic chelant
Prior art date
Application number
AT92920822T
Other languages
English (en)
Inventor
Alan D Watson
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of ATE174800T1 publication Critical patent/ATE174800T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT92920822T 1991-10-07 1992-10-06 Dendrimere polychelate ATE174800T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/772,349 US5914095A (en) 1989-04-07 1991-10-07 Polychelants containg amide bonds

Publications (1)

Publication Number Publication Date
ATE174800T1 true ATE174800T1 (de) 1999-01-15

Family

ID=25094771

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92920822T ATE174800T1 (de) 1991-10-07 1992-10-06 Dendrimere polychelate

Country Status (10)

Country Link
US (1) US5914095A (de)
EP (1) EP0607222B1 (de)
JP (1) JPH07503031A (de)
AT (1) ATE174800T1 (de)
AU (1) AU671601B2 (de)
CA (1) CA2120763A1 (de)
DE (1) DE69227998T2 (de)
HK (1) HK1002101A1 (de)
SG (1) SG48985A1 (de)
WO (1) WO1993006868A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
ES2132392T3 (es) * 1993-02-24 1999-08-16 Dade Behring Inc Inmovilizacion de reactivos de ensayo de enlace especifico.
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
DE69534990T2 (de) * 1994-04-20 2006-10-05 Amersham Health Salutar Inc. Kontrastmittel
DE4425857A1 (de) 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP0709100A1 (de) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Kontrastmittel mit mehreren Detektionsgruppen pro Molekül
US5558968A (en) * 1995-01-26 1996-09-24 Hewlett-Packard Company Dendrimeric toner particles for liquid electrophotography
US6770261B2 (en) * 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
BR9610241A (pt) 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
EP1011736A2 (de) * 1997-01-29 2000-06-28 Nycomed Imaging As Polymere
WO1998056427A1 (fr) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Agent de contrast
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2309749A1 (en) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
US5938934A (en) * 1998-01-13 1999-08-17 Dow Corning Corporation Dendrimer-based nanoscopic sponges and metal composites
AUPP584398A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Inhibition of toxic materials or substances
CZ2002343A3 (cs) 1999-07-29 2002-08-14 Epix Medical, Inc. Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
EP1390079A2 (de) 2000-11-20 2004-02-25 Board of Regents University of Texas System Paramagnetischen metallion-basierte makrozyklische kontrastmitteln
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
IL157444A0 (en) 2001-02-23 2004-03-28 Bristol Myers Squibb Pharma Co Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20050019267A1 (en) * 2001-06-25 2005-01-27 Brechbiel Martin W Macromolecular imaging agents for liver imaging
TWI221406B (en) * 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US6852842B2 (en) * 2002-08-26 2005-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for functional kidney imaging using small dendrimer contrast agents
AU2003299140B2 (en) 2002-09-24 2008-07-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for convection enhanced delivery of therapeutic agents
US20040258614A1 (en) * 2003-06-20 2004-12-23 University Of Maryland, Baltimore Microparticles for microarterial imaging and radiotherapy
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
EP1805188A4 (de) 2004-09-30 2010-03-03 Mds Analytical Technologies Us Lumineszente lanthanidkomplexe
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates
ATE439866T1 (de) * 2005-04-26 2009-09-15 Koninkl Philips Electronics Nv Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
WO2007137418A1 (en) 2006-05-27 2007-12-06 Winnik Mitchell A Polymer backbone element tags
KR101502180B1 (ko) * 2006-08-30 2015-03-12 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
DE102007002726A1 (de) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
DE102008045937B4 (de) * 2008-04-11 2017-01-26 Johannes-Gutenberg-Universität Mainz Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US8524457B2 (en) 2009-09-22 2013-09-03 William Patterson Method for the selection of specific affinity binders by homogeneous noncompetitive assay
US9125942B2 (en) 2010-01-19 2015-09-08 Northwestern University Paramagnetic metal-nanodiamond conjugates
ITMI20101054A1 (it) * 2010-06-11 2011-12-12 Carlo Ghisalberti Composizioni e sistemi di sequestro ed immunodisattivazione di nichel e cobalto
US20120271100A1 (en) 2011-04-14 2012-10-25 Northwestern University Compositions and methods for the detection of zinc
WO2013134686A1 (en) 2012-03-09 2013-09-12 Promega Corporation pH SENSORS
US20140134665A1 (en) 2012-11-15 2014-05-15 Northwestern University Compositions and methods for the detection of zinc
US9551705B2 (en) 2012-12-12 2017-01-24 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
PT2970412T (pt) 2013-03-15 2022-09-13 Promega Corp Ativação de bioluminescência por complementação estrutural
CN106062565B (zh) 2014-02-27 2018-06-08 宝洁公司 用于评估生物可利用的锌的方法
US10151764B2 (en) 2014-05-15 2018-12-11 The Cleveland HeartLab Compositions and methods for purification and detection of HDL and ApoA1
EP3164507B1 (de) 2014-07-02 2020-02-12 Promega Corporation Umkehrbare metallionenchelatoren
EP4219736A1 (de) 2014-09-12 2023-08-02 Promega Corporation Interne proteinmarker
US10406249B2 (en) 2015-06-26 2019-09-10 Northwestern University Gd(III)-dithiolane gold nanoparticle conjugates
JP2022526907A (ja) 2019-03-20 2022-05-27 プロメガ コーポレイション 光親和性プローブ
US11360096B2 (en) 2019-05-16 2022-06-14 Duke University Complex BRET technique for measuring biological interactions
EP4065699A1 (de) 2019-11-27 2022-10-05 Promega Corporation Mehrteilige luciferase-peptide und polypeptide
WO2023215514A2 (en) 2022-05-04 2023-11-09 Promega Corporation Bioluminescence-triggered photocatalytic labeling

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
EP0247156B1 (de) * 1985-11-18 1993-06-23 Access Pharmaceuticals Inc. Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung)
US4871779A (en) * 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
DE3786000T3 (de) * 1986-08-18 1997-08-21 Dow Chemical Co Conjugate dichter Sterne.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4857599A (en) * 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
BR8907507A (pt) * 1988-06-24 1991-06-11 Dow Chemical Co Quelante bifuncional macrociclico,seus complexos e seus conjugados com anticorpos
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
DK0429644T3 (da) * 1989-05-26 1996-01-22 Ramaswamy Subramanian Chelat-dannende midler til binding af metalioner til proteiner
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
AU2675792A (en) 1993-05-03
JPH07503031A (ja) 1995-03-30
DE69227998D1 (de) 1999-02-04
CA2120763A1 (en) 1993-04-15
US5914095A (en) 1999-06-22
SG48985A1 (en) 1998-05-18
DE69227998T2 (de) 1999-08-19
EP0607222A1 (de) 1994-07-27
EP0607222B1 (de) 1998-12-23
HK1002101A1 (en) 1998-07-31
AU671601B2 (en) 1996-09-05
WO1993006868A1 (en) 1993-04-15

Similar Documents

Publication Publication Date Title
ATE174800T1 (de) Dendrimere polychelate
DE69027603D1 (de) Chelatbildner
NO954434D0 (no) Bioaktive og/eller målsökende dendrimer-konjugater
ATE451124T1 (de) Polysaccharid-peptid-konjugate
CA2158054A1 (en) Conjugates of proteins and bifunctional ligands
DK1261377T3 (da) Immunmodulatoriske formuleringer og fremgangsmåder til anvendelse af disse
WO2002087498A8 (en) Diagnostic imaging compositions, their methods of synthesis and use
NO944019D0 (no) Karboksamid-modifiserte polyamin-chelatorer og radioaktive komplekser og konjugater
DE68922368T2 (de) Chelatbildner, die eine ortho-bindende funktionelle Gruppe besitzen und Komplexe davon.
ATE194777T1 (de) Mehrfachkomponenten-inklusionskomplexe enthaltend einen sauren arzneistoff, ein zyklodextrin und eine base
DK0570575T3 (da) Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
DE59610242D1 (de) Zaunpfosten
DE69014655T2 (de) Schlagfeste Polymermischungen aus Polyamiden, Anhydridcopolymeren und funktionalisierten Elastomeren.
ATE214631T1 (de) Konjugat, geeignet zur bindung von substanzen
Fredericks With the house
RU93057952A (ru) Биологический активный макромолекулярный конъюгат, гидразинсодержащие конъюгаты полипептидов и гликополипептидов с полимерами

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties