NO944019D0 - Karboksamid-modifiserte polyamin-chelatorer og radioaktive komplekser og konjugater - Google Patents

Karboksamid-modifiserte polyamin-chelatorer og radioaktive komplekser og konjugater

Info

Publication number
NO944019D0
NO944019D0 NO944019A NO944019A NO944019D0 NO 944019 D0 NO944019 D0 NO 944019D0 NO 944019 A NO944019 A NO 944019A NO 944019 A NO944019 A NO 944019A NO 944019 D0 NO944019 D0 NO 944019D0
Authority
NO
Norway
Prior art keywords
carboxamide
conjugates
chelators
modified polyamine
complexes
Prior art date
Application number
NO944019A
Other languages
English (en)
Other versions
NO944019L (no
NO304552B1 (no
Inventor
Jr William J Kruper
William A Fordyce
A Dean Sherry
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO944019D0 publication Critical patent/NO944019D0/no
Publication of NO944019L publication Critical patent/NO944019L/no
Publication of NO304552B1 publication Critical patent/NO304552B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
  • Medicinal Preparation (AREA)
NO944019A 1992-04-24 1994-10-21 Kompleksforbindelser, konjugater, farmas°ytiske preparater inneholdende slike og forbindelser NO304552B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/874,244 US5310535A (en) 1992-04-24 1992-04-24 Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
PCT/US1993/003844 WO1993021963A2 (en) 1992-04-24 1993-04-23 Carboxamide modified polyamine chelators and radioactive complexes and conjugation

Publications (3)

Publication Number Publication Date
NO944019D0 true NO944019D0 (no) 1994-10-21
NO944019L NO944019L (no) 1994-12-12
NO304552B1 NO304552B1 (no) 1999-01-11

Family

ID=25363311

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944019A NO304552B1 (no) 1992-04-24 1994-10-21 Kompleksforbindelser, konjugater, farmas°ytiske preparater inneholdende slike og forbindelser

Country Status (18)

Country Link
US (2) US5310535A (no)
EP (1) EP0637253B1 (no)
JP (1) JP3850870B2 (no)
KR (1) KR100245941B1 (no)
AT (1) ATE164522T1 (no)
AU (1) AU674853B2 (no)
CA (1) CA2134092C (no)
DE (1) DE69317771T2 (no)
DK (1) DK0637253T3 (no)
ES (1) ES2114051T3 (no)
FI (1) FI944973A (no)
GR (1) GR3026533T3 (no)
HK (1) HK1006632A1 (no)
HU (1) HU222761B1 (no)
NO (1) NO304552B1 (no)
NZ (1) NZ252867A (no)
SG (1) SG49756A1 (no)
WO (1) WO1993021963A2 (no)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
ATE298561T1 (de) 1993-04-22 2005-07-15 Emisphere Tech Inc Orale dareichungsform
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
DE19681560T1 (de) 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
US6007819A (en) * 1995-10-17 1999-12-28 Dovetail Technologies, Inc. Methods of inducing immunity using low molecular weight immune stimulants
SI9720025A (sl) * 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
CA2258264A1 (en) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
EP1149066B1 (en) 1999-02-05 2005-11-09 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
FR2802928B1 (fr) * 1999-12-22 2003-01-31 Air Liquide Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds
US6565828B2 (en) 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
IL157444A0 (en) 2001-02-23 2004-03-28 Bristol Myers Squibb Pharma Co Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
JP4912153B2 (ja) 2003-12-01 2012-04-11 イミューノメディクス、インコーポレイテッド タンパク質とキレート剤とのコンジュゲートを調製するための改良された方法
EP1768558A4 (en) 2004-06-09 2009-11-25 Kereos Inc LIPOPHILES DERIVATIVES OF CHELATE MONOAMIDES
EP1999118B1 (en) * 2006-03-14 2012-10-17 Mallinckrodt LLC Metal complexes of tetraazamacrocycle derivatives
WO2010000714A2 (en) * 2008-07-04 2010-01-07 Oslo Universitetssykehus Hf Radioimmunoconjugate kit
US10729669B2 (en) 2015-07-28 2020-08-04 University Of Iowa Research Foundation Compositions and methods for treating cancer
AU2017281940B2 (en) 2016-06-24 2024-07-11 University Of Iowa Research Foundation Compositions and methods of treating melanoma
WO2019240884A2 (en) 2018-04-27 2019-12-19 University Of Iowa Research Foundation Compositions for chelating metals at low temperatures
US11529335B2 (en) 2020-07-31 2022-12-20 University Of Iowa Research Foundation Compositions and methods for treating cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
EP0327365B1 (en) * 1988-02-03 1994-06-15 Hybritech Incorporated Improvements in or relating to modified haptens useful as imaging and therapeutic agents
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
JP2831073B2 (ja) * 1988-06-24 1998-12-02 ザ ダウ ケミカル カンパニー 大環状二官能キレート剤、その錯体及びそれらの抗体接合体
JP2930708B2 (ja) * 1988-12-23 1999-08-03 ザ ダウ ケミカル カンパニー イソチオシアナト官能化金属錯体の製造方法
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
DE69024826T2 (de) * 1989-02-10 1996-06-27 Celltech Therapeutics Ltd Aza-Macrozyklen und Verfahren zu deren Herstellung
TW213864B (no) * 1991-08-01 1993-10-01 Squibb & Sons Inc

Also Published As

Publication number Publication date
FI944973A0 (fi) 1994-10-21
EP0637253B1 (en) 1998-04-01
NO944019L (no) 1994-12-12
SG49756A1 (en) 1998-06-15
KR950701231A (ko) 1995-03-23
GR3026533T3 (en) 1998-07-31
ATE164522T1 (de) 1998-04-15
AU674853B2 (en) 1997-01-16
KR100245941B1 (ko) 2000-04-01
AU4292693A (en) 1993-11-29
HK1006632A1 (en) 1999-03-05
ES2114051T3 (es) 1998-05-16
HU222761B1 (hu) 2003-10-28
WO1993021963A3 (en) 1993-12-09
DK0637253T3 (da) 1999-02-01
US5310535A (en) 1994-05-10
US5739323A (en) 1998-04-14
DE69317771D1 (de) 1998-05-07
WO1993021963A2 (en) 1993-11-11
NO304552B1 (no) 1999-01-11
JPH07506365A (ja) 1995-07-13
CA2134092A1 (en) 1993-11-11
NZ252867A (en) 1997-03-24
DE69317771T2 (de) 1998-07-30
HUT70429A (en) 1995-10-30
FI944973A (fi) 1994-12-02
CA2134092C (en) 2003-07-29
EP0637253A1 (en) 1995-02-08
JP3850870B2 (ja) 2006-11-29

Similar Documents

Publication Publication Date Title
NO944019D0 (no) Karboksamid-modifiserte polyamin-chelatorer og radioaktive komplekser og konjugater
BR8907507A (pt) Quelante bifuncional macrociclico,seus complexos e seus conjugados com anticorpos
GR3026658T3 (en) Hydrazino-type radionuclide chelators having an n 3?s configuration
NO166267C (no) Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.
DE3882832D1 (de) Weicheisenmagnet-duennfilme.
CA2001765A1 (en) Chelants possessing ortho ligating functionality and complexes thereof
NO162054C (no) Fremgangsmaate for aa danne permanente boelger i haar.
FR2659478B1 (fr) Composition magnetique et ses applications.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees