DE69227998D1 - Dendrimere polychelate - Google Patents

Dendrimere polychelate

Info

Publication number
DE69227998D1
DE69227998D1 DE69227998T DE69227998T DE69227998D1 DE 69227998 D1 DE69227998 D1 DE 69227998D1 DE 69227998 T DE69227998 T DE 69227998T DE 69227998 T DE69227998 T DE 69227998T DE 69227998 D1 DE69227998 D1 DE 69227998D1
Authority
DE
Germany
Prior art keywords
dendrimer
conjugated
site
polychelates
macrocyclic chelant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69227998T
Other languages
English (en)
Other versions
DE69227998T2 (de
Inventor
Alan D Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of DE69227998D1 publication Critical patent/DE69227998D1/de
Publication of DE69227998T2 publication Critical patent/DE69227998T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69227998T 1991-10-07 1992-10-06 Dendrimere polychelate Expired - Lifetime DE69227998T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/772,349 US5914095A (en) 1989-04-07 1991-10-07 Polychelants containg amide bonds
PCT/EP1992/002308 WO1993006868A1 (en) 1991-10-07 1992-10-06 Dendrimeric polychelants

Publications (2)

Publication Number Publication Date
DE69227998D1 true DE69227998D1 (de) 1999-02-04
DE69227998T2 DE69227998T2 (de) 1999-08-19

Family

ID=25094771

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227998T Expired - Lifetime DE69227998T2 (de) 1991-10-07 1992-10-06 Dendrimere polychelate

Country Status (10)

Country Link
US (1) US5914095A (de)
EP (1) EP0607222B1 (de)
JP (1) JPH07503031A (de)
AT (1) ATE174800T1 (de)
AU (1) AU671601B2 (de)
CA (1) CA2120763A1 (de)
DE (1) DE69227998T2 (de)
HK (1) HK1002101A1 (de)
SG (1) SG48985A1 (de)
WO (1) WO1993006868A1 (de)

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CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
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US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
DE69534990T2 (de) * 1994-04-20 2006-10-05 Amersham Health Salutar Inc. Kontrastmittel
DE4425857A1 (de) * 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP0709100A1 (de) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Kontrastmittel mit mehreren Detektionsgruppen pro Molekül
US5558968A (en) * 1995-01-26 1996-09-24 Hewlett-Packard Company Dendrimeric toner particles for liquid electrophotography
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
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US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
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US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
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US6852842B2 (en) * 2002-08-26 2005-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for functional kidney imaging using small dendrimer contrast agents
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US20040258614A1 (en) * 2003-06-20 2004-12-23 University Of Maryland, Baltimore Microparticles for microarterial imaging and radiotherapy
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US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates
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CN101506179B (zh) * 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
DE102007002726A1 (de) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
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DE102008045937B4 (de) * 2008-04-11 2017-01-26 Johannes-Gutenberg-Universität Mainz Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons
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ITMI20101054A1 (it) * 2010-06-11 2011-12-12 Carlo Ghisalberti Composizioni e sistemi di sequestro ed immunodisattivazione di nichel e cobalto
US20120271100A1 (en) 2011-04-14 2012-10-25 Northwestern University Compositions and methods for the detection of zinc
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US20140134665A1 (en) 2012-11-15 2014-05-15 Northwestern University Compositions and methods for the detection of zinc
CN104853767B (zh) 2012-12-12 2017-04-05 普洛麦格公司 用于捕获生物活性剂的细胞标靶的组合物和方法
CN117024548A (zh) 2013-03-15 2023-11-10 普洛麦格公司 通过结构互补激活生物发光
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
EP3110391B1 (de) 2014-02-27 2018-01-31 The Procter and Gamble Company Methode zur bestimmung von bio-verfügbarem zink
CN113834925A (zh) 2014-05-15 2021-12-24 克利夫兰心脏实验室公司 用于hdl和apoa1的纯化和检测的组合物和方法
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Also Published As

Publication number Publication date
US5914095A (en) 1999-06-22
JPH07503031A (ja) 1995-03-30
AU2675792A (en) 1993-05-03
HK1002101A1 (en) 1998-07-31
DE69227998T2 (de) 1999-08-19
EP0607222A1 (de) 1994-07-27
EP0607222B1 (de) 1998-12-23
ATE174800T1 (de) 1999-01-15
WO1993006868A1 (en) 1993-04-15
SG48985A1 (en) 1998-05-18
CA2120763A1 (en) 1993-04-15
AU671601B2 (en) 1996-09-05

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