ATE173269T1 - Verfahren zur herstellung von morphin-6- glucoronide oder substituierte morphin-6- glucoronide - Google Patents

Verfahren zur herstellung von morphin-6- glucoronide oder substituierte morphin-6- glucoronide

Info

Publication number
ATE173269T1
ATE173269T1 AT92916104T AT92916104T ATE173269T1 AT E173269 T1 ATE173269 T1 AT E173269T1 AT 92916104 T AT92916104 T AT 92916104T AT 92916104 T AT92916104 T AT 92916104T AT E173269 T1 ATE173269 T1 AT E173269T1
Authority
AT
Austria
Prior art keywords
glucoronides
morphin
substituted
producing
morphine
Prior art date
Application number
AT92916104T
Other languages
English (en)
Inventor
Feodor Scheinmann
Keith William Lumbard
Richard Talbot Brown
Stephen Patrick Mayalarp
Neil Edward Carter
Original Assignee
Salford Ultrafine Chem & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salford Ultrafine Chem & Res filed Critical Salford Ultrafine Chem & Res
Application granted granted Critical
Publication of ATE173269T1 publication Critical patent/ATE173269T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT92916104T 1991-08-06 1992-08-04 Verfahren zur herstellung von morphin-6- glucoronide oder substituierte morphin-6- glucoronide ATE173269T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919116909A GB9116909D0 (en) 1991-08-06 1991-08-06 Morphine derivatives

Publications (1)

Publication Number Publication Date
ATE173269T1 true ATE173269T1 (de) 1998-11-15

Family

ID=10699556

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92916104T ATE173269T1 (de) 1991-08-06 1992-08-04 Verfahren zur herstellung von morphin-6- glucoronide oder substituierte morphin-6- glucoronide

Country Status (15)

Country Link
US (2) US5621087A (de)
EP (1) EP0597915B1 (de)
JP (1) JP3642576B2 (de)
AT (1) ATE173269T1 (de)
AU (1) AU672365B2 (de)
CA (2) CA2114838C (de)
DE (1) DE69227588T2 (de)
DK (1) DK0597915T3 (de)
ES (1) ES2130175T3 (de)
FI (1) FI940534A (de)
GB (1) GB9116909D0 (de)
GR (1) GR3029369T3 (de)
HU (1) HUT68169A (de)
NO (1) NO940349L (de)
WO (1) WO1993003051A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5977326A (en) * 1991-08-06 1999-11-02 Salford Ultrafine Chemicals And Research Limited Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
GB9325065D0 (en) * 1993-12-07 1994-02-02 Salford Ultrafine Chem & Res An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
EP0632041A1 (de) * 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen Neue Morphin Derivate mit verbesserten analgetischen und narkotischen Eigenschaften
CA2143864C (en) * 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
GB2282758A (en) * 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
GB9423542D0 (en) * 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
WO1996028451A1 (en) * 1995-03-14 1996-09-19 Euroceltique S.A. Morphine-3-esters
AT403162B (de) * 1995-10-11 1997-11-25 Nycomed Austria Gmbh Neue kristallform von morphin-6-glucuronid
DE19541921A1 (de) * 1995-11-10 1997-05-15 Nycomed Arzneimittel Gmbh Neue Kristallform von Morphin-6-glucuronid
JPH10513485A (ja) * 1995-11-29 1998-12-22 ロラボ エセ エレ オピエート性物質の糖結合体
DE19602964A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
ES2201482T3 (es) * 1997-04-14 2004-03-16 Ufc Limited Derivados de la morfina.
GB9711118D0 (en) * 1997-05-29 1997-07-23 Rolabo Sl Compound
CA2319833A1 (en) * 1998-02-02 1999-08-05 Lev Yudovitch Glycosidation of 4,5-epoxymorphinan-6-ols
CA2331866A1 (en) * 1998-05-13 1999-11-18 Arie L. Gutman Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
HUP0102333A3 (en) 1998-06-06 2003-07-28 Cenes Ltd Cambridge Morphine-6-glucuronide synthesis
SE9901257D0 (sv) * 1999-04-09 1999-04-09 Hel Ab Behandling av smärta efter ledoperation
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
US6339107B1 (en) * 2000-08-02 2002-01-15 Syntex (U.S.A.) Llc Methods for treatment of Emphysema using 13-cis retinoic acid
AR034362A1 (es) * 2001-06-05 2004-02-18 Control Delivery Systems Compuestos analgesicos de liberacion prolongada
DE60315043T2 (de) 2002-09-20 2008-04-10 Queen's University At Kingston, Kingston Nachweis biologischer moleküle mittels differentieller aufteilung von enzymsubstraten und -produkten
MXPA06008931A (es) 2004-02-06 2007-01-26 Euro Celtique Sa Metodos para elaborar morfinonas 3-o protegidas y carboxilatos de dienol morfinona 3-o protegidos.
FR2907121B1 (fr) 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques
FR2939437B1 (fr) 2008-12-10 2010-12-17 Sanofi Aventis Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939436B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Synthese de morphine-6-glucuronide ou de l'un de ses derives
FR2939796B1 (fr) 2008-12-11 2010-12-17 Sanofi Aventis Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
WO2011156915A2 (en) 2010-06-18 2011-12-22 Pathogen Detection Systems, Inc. Method and system for detecting biological molecules in samples
CN103421063B (zh) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法
CN103864866B (zh) * 2014-03-26 2016-05-25 宜昌人福药业有限责任公司 一种吗啡-6-β-D-葡萄糖醛酸苷的合成方法及其中间体化合物
AU2023246772A1 (en) 2022-03-29 2024-01-18 Illumina Inc. Chromenoquinoline dyes and uses in sequencing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058243T3 (es) * 1988-01-12 1994-11-01 Baker Norton Pharma Derivados del acido glucuronico de antagonistas de opiaceos.
US4774230A (en) * 1988-03-26 1988-09-27 Ivax Laboratories, Inc. Glucuronic acid derivatives of opioid antagonists
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB9325065D0 (en) * 1993-12-07 1994-02-02 Salford Ultrafine Chem & Res An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.

Also Published As

Publication number Publication date
DE69227588D1 (de) 1998-12-17
US5621087A (en) 1997-04-15
CA2114838C (en) 2003-10-14
ES2130175T3 (es) 1999-07-01
WO1993003051A1 (en) 1993-02-18
JP3642576B2 (ja) 2005-04-27
NO940349L (no) 1994-03-16
EP0597915B1 (de) 1998-11-11
CA2412554C (en) 2006-10-31
HUT68169A (en) 1995-05-29
GR3029369T3 (en) 1999-05-28
AU2389492A (en) 1993-03-02
DK0597915T3 (da) 1999-07-26
FI940534A (fi) 1994-04-05
US6046313A (en) 2000-04-04
EP0597915A1 (de) 1994-05-25
NO940349D0 (no) 1994-02-02
AU672365B2 (en) 1996-10-03
HU9400330D0 (en) 1994-05-30
DE69227588T2 (de) 2000-01-27
CA2114838A1 (en) 1993-02-18
CA2412554A1 (en) 1993-02-18
JPH07501317A (ja) 1995-02-09
GB9116909D0 (en) 1991-09-18
FI940534A0 (fi) 1994-02-04

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Legal Events

Date Code Title Description
EEFA Change of the company name
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee