ATE167859T1 - Antiproliferative 4h-naphtho(1,2-b)pyranderivate - Google Patents
Antiproliferative 4h-naphtho(1,2-b)pyranderivateInfo
- Publication number
- ATE167859T1 ATE167859T1 AT92309169T AT92309169T ATE167859T1 AT E167859 T1 ATE167859 T1 AT E167859T1 AT 92309169 T AT92309169 T AT 92309169T AT 92309169 T AT92309169 T AT 92309169T AT E167859 T1 ATE167859 T1 AT E167859T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- hydroxy
- carboxy
- Prior art date
Links
- XGLHSMNFZCEVOV-UHFFFAOYSA-N 4h-benzo[h]chromene Chemical class C1=CC2=CC=CC=C2C2=C1CC=CO2 XGLHSMNFZCEVOV-UHFFFAOYSA-N 0.000 title 1
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004185 ester group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 150000002825 nitriles Chemical class 0.000 abstract 2
- -1 trifluoromethoxy, carboxy Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919121358A GB9121358D0 (en) | 1991-10-09 | 1991-10-09 | Pharmaceutical compounds |
| GB929213058A GB9213058D0 (en) | 1992-06-19 | 1992-06-19 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167859T1 true ATE167859T1 (de) | 1998-07-15 |
Family
ID=26299655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92309169T ATE167859T1 (de) | 1991-10-09 | 1992-10-08 | Antiproliferative 4h-naphtho(1,2-b)pyranderivate |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5284868A (de) |
| EP (1) | EP0537949B1 (de) |
| JP (1) | JPH05194477A (de) |
| KR (1) | KR100228841B1 (de) |
| CN (1) | CN1034938C (de) |
| AT (1) | ATE167859T1 (de) |
| AU (1) | AU658003B2 (de) |
| CA (1) | CA2079428A1 (de) |
| CZ (1) | CZ281688B6 (de) |
| DE (1) | DE69226060T2 (de) |
| DK (1) | DK0537949T3 (de) |
| ES (1) | ES2117035T3 (de) |
| FI (1) | FI924551A (de) |
| HU (1) | HU218916B (de) |
| IL (1) | IL103356A (de) |
| MX (1) | MX9205714A (de) |
| MY (1) | MY111368A (de) |
| NO (1) | NO301587B1 (de) |
| NZ (1) | NZ244627A (de) |
| PH (1) | PH30659A (de) |
| RU (1) | RU2071472C1 (de) |
| TW (1) | TW221292B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9203497D0 (en) * | 1992-02-19 | 1992-04-08 | Lilly Industries Ltd | Pharmaceutical compounds |
| EP1004584A3 (de) * | 1992-11-18 | 2000-07-05 | Eli Lilly And Company Limited | Pyranochinolin Derivate als Inhibitoren der Zellproliferation |
| GB9306062D0 (en) * | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
| EP0619314A1 (de) * | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H-Naphtho 2,1-b pyran Derivate und ihre Verwendung als Arzneimittel |
| WO1995008289A2 (en) * | 1993-09-16 | 1995-03-30 | Scimed Life Systems, Inc. | Percutaneous repair of cardiovascular anomalies and repair compositions |
| US5407955A (en) * | 1994-02-18 | 1995-04-18 | Eli Lilly And Company | Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease |
| US5665591A (en) * | 1994-12-06 | 1997-09-09 | Trustees Of Boston University | Regulation of smooth muscle cell proliferation |
| WO1997045105A1 (en) * | 1996-05-24 | 1997-12-04 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing diseases of body passageways |
| IL119069A0 (en) * | 1996-08-14 | 1996-11-14 | Mor Research Applic Ltd | Pharmaceutical composition comprising tyrphostins |
| JP2003513967A (ja) | 1999-11-05 | 2003-04-15 | サイトビア インコーポレイテッド | カスパーゼのアクチベーターおよびアポトーシスのインデューサーとしての置換４ｈクロメンおよびアナログ、ならびにその使用 |
| US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| EP1392683B1 (de) * | 2001-05-16 | 2009-12-02 | Cytovia, Inc. | Substituierte 4h-chromene und analoga als aktivatoren von caspasen und induktoren von apoptose, und deren verwendung als antikrebsmittel |
| WO2002092076A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
| US7476741B2 (en) * | 2002-05-16 | 2009-01-13 | Cytovia, Inc. | Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2003097806A2 (en) * | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US20040127519A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors |
| US20040127511A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
| NZ553688A (en) * | 2004-09-09 | 2011-05-27 | Florey Howard Inst | Enzyme inhibitors for the inhibition of insulin-regulated aminopeptidase |
| WO2006088315A1 (en) * | 2005-02-16 | 2006-08-24 | Md Bioalpha Co., Ltd. | Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases |
| US20080183282A1 (en) * | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
| NZ585338A (en) | 2007-11-19 | 2012-08-31 | Howard Florey Inst | Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof |
| EA015364B1 (ru) * | 2009-03-18 | 2011-06-30 | Учреждение Российской Академии Наук Институт Элементоорганических Соединений Им. А.Н. Несмеянова Ран (Инэос Ран) | 6,6'-диизопропил-8,8'-диметил-2,2'-динитро-3,3'-бис(трифторметил)- 3н,3'н-[9,9']ди[бензо(f)хроменил]-5,10,5',10'-тетраол, обладающий противоопухолевой и противогрибковой активностью, и способ его получения |
| WO2012062905A2 (en) | 2010-11-12 | 2012-05-18 | Deutsches Krebsforschungszentrum (Dkfz) | Chromene derivatives and their analoga as wnt pathway antagonists |
| US20140275174A1 (en) * | 2011-11-10 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | TREATMENT OF OVARIAN CANCER WITH 2-AMINO-4H-NAPHTHO[1,2-b]PYRAN-3-CARBONITRILES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU724509A1 (ru) * | 1978-09-21 | 1980-03-30 | Пермский государственный фармацевтический институт | Способ получени 2-ароил-3н- нафто 2,1-в пиранонов-3 |
| WO1989009769A1 (en) * | 1988-04-14 | 1989-10-19 | Yamanouchi Pharmaceutical Co., Ltd. | Substance q-2819 and process for its preparation |
-
1992
- 1992-09-25 US US07/951,629 patent/US5284868A/en not_active Expired - Fee Related
- 1992-09-29 CA CA002079428A patent/CA2079428A1/en not_active Abandoned
- 1992-10-05 CZ CS923035A patent/CZ281688B6/cs not_active IP Right Cessation
- 1992-10-05 PH PH45043A patent/PH30659A/en unknown
- 1992-10-05 TW TW081107894A patent/TW221292B/zh active
- 1992-10-05 IL IL103356A patent/IL103356A/en not_active IP Right Cessation
- 1992-10-05 AU AU26216/92A patent/AU658003B2/en not_active Ceased
- 1992-10-06 RU SU925052861A patent/RU2071472C1/ru active
- 1992-10-06 NZ NZ244627A patent/NZ244627A/en unknown
- 1992-10-06 MX MX9205714A patent/MX9205714A/es not_active IP Right Cessation
- 1992-10-07 KR KR1019920018309A patent/KR100228841B1/ko not_active IP Right Cessation
- 1992-10-07 MY MYPI92001807A patent/MY111368A/en unknown
- 1992-10-08 NO NO923910A patent/NO301587B1/no not_active IP Right Cessation
- 1992-10-08 ES ES92309169T patent/ES2117035T3/es not_active Expired - Lifetime
- 1992-10-08 HU HU9203183A patent/HU218916B/hu not_active IP Right Cessation
- 1992-10-08 JP JP4269002A patent/JPH05194477A/ja active Pending
- 1992-10-08 FI FI924551A patent/FI924551A/fi unknown
- 1992-10-08 CN CN92111625A patent/CN1034938C/zh not_active Expired - Fee Related
- 1992-10-08 DK DK92309169T patent/DK0537949T3/da active
- 1992-10-08 AT AT92309169T patent/ATE167859T1/de not_active IP Right Cessation
- 1992-10-08 DE DE69226060T patent/DE69226060T2/de not_active Expired - Fee Related
- 1992-10-08 EP EP92309169A patent/EP0537949B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1073437A (zh) | 1993-06-23 |
| MY111368A (en) | 1999-12-31 |
| IL103356A0 (en) | 1993-03-15 |
| CZ281688B6 (cs) | 1996-12-11 |
| FI924551A0 (fi) | 1992-10-08 |
| TW221292B (de) | 1994-02-21 |
| ES2117035T3 (es) | 1998-08-01 |
| DE69226060T2 (de) | 1998-11-19 |
| AU658003B2 (en) | 1995-03-30 |
| EP0537949A1 (de) | 1993-04-21 |
| HU218916B (hu) | 2000-12-28 |
| CN1034938C (zh) | 1997-05-21 |
| CA2079428A1 (en) | 1993-04-10 |
| RU2071472C1 (ru) | 1997-01-10 |
| KR100228841B1 (ko) | 1999-11-01 |
| HU9203183D0 (en) | 1992-12-28 |
| AU2621692A (en) | 1993-04-22 |
| CZ303592A3 (en) | 1993-12-15 |
| HUT62281A (en) | 1993-04-28 |
| PH30659A (en) | 1997-09-16 |
| NO923910L (no) | 1993-04-13 |
| NO923910D0 (no) | 1992-10-08 |
| IL103356A (en) | 1998-02-22 |
| EP0537949B1 (de) | 1998-07-01 |
| MX9205714A (es) | 1993-04-01 |
| KR930007931A (ko) | 1993-05-20 |
| DE69226060D1 (de) | 1998-08-06 |
| NZ244627A (en) | 1994-12-22 |
| JPH05194477A (ja) | 1993-08-03 |
| DK0537949T3 (da) | 1999-02-15 |
| NO301587B1 (no) | 1997-11-17 |
| FI924551A (fi) | 1993-04-10 |
| US5284868A (en) | 1994-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |