ATE165359T1 - Imidderivate, ihre herstellung und verwendung - Google Patents

Imidderivate, ihre herstellung und verwendung

Info

Publication number
ATE165359T1
ATE165359T1 AT91111223T AT91111223T ATE165359T1 AT E165359 T1 ATE165359 T1 AT E165359T1 AT 91111223 T AT91111223 T AT 91111223T AT 91111223 T AT91111223 T AT 91111223T AT E165359 T1 ATE165359 T1 AT E165359T1
Authority
AT
Austria
Prior art keywords
group
aromatic
hydrocarbon ring
aromatic hydrocarbon
chem
Prior art date
Application number
AT91111223T
Other languages
English (en)
Inventor
Ikutaro Saji
Masayuki Muto
Norihiko Tanno
Mayumi Yoshigi
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16080314&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE165359(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Application granted granted Critical
Publication of ATE165359T1 publication Critical patent/ATE165359T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
AT91111223T 1990-07-06 1991-07-05 Imidderivate, ihre herstellung und verwendung ATE165359T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18027190 1990-07-06

Publications (1)

Publication Number Publication Date
ATE165359T1 true ATE165359T1 (de) 1998-05-15

Family

ID=16080314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91111223T ATE165359T1 (de) 1990-07-06 1991-07-05 Imidderivate, ihre herstellung und verwendung

Country Status (9)

Country Link
US (2) US5532372A (de)
EP (1) EP0464846B1 (de)
JP (1) JP2800953B2 (de)
AT (1) ATE165359T1 (de)
CA (1) CA2046429C (de)
DE (2) DE69129282T4 (de)
DK (1) DK0464846T3 (de)
ES (1) ES2115599T3 (de)
GR (1) GR3026697T3 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
JPH10204012A (ja) * 1997-01-24 1998-08-04 Daicel Chem Ind Ltd ３−ヒドロキシメチルシクロアルカノール類およびその製造方法
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en) * 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (de) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
JP4868695B2 (ja) 2000-09-22 2012-02-01 大日本住友製薬株式会社 崩壊性が良好な経口製剤
US20040087548A1 (en) * 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US8552054B2 (en) 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
JP4634694B2 (ja) * 2001-03-23 2011-02-16 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪アルコール薬物複合体
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
JP3977162B2 (ja) * 2002-06-21 2007-09-19 株式会社バンダイナムコゲームス キャラクタ情報管理装置、プログラム及び情報記憶媒体
ES2685780T3 (es) 2002-08-22 2018-10-11 Sumitomo Dainippon Pharma Co., Ltd. Agente para el tratamiento de esquizofrenia
CN1826338B (zh) 2003-06-23 2011-07-13 大日本住友制药株式会社 老年性痴呆症治疗药
JP4610485B2 (ja) * 2003-07-29 2011-01-12 大日本住友製薬株式会社 イミド化合物の製造方法
KR100578104B1 (ko) * 2003-12-16 2006-05-10 한국과학기술원 코발트-질소 박막을 이용한 코발트 다이실리사이드에피층의 형성방법
WO2005080976A1 (ja) * 2004-02-20 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 統合失調症の記憶・学習機能障害治療薬のin vivoスクリーニング方法
JP4708012B2 (ja) * 2004-12-15 2011-06-22 大日本住友製薬株式会社 第四級アンモニウム塩の製造法
JP2006169154A (ja) * 2004-12-15 2006-06-29 Sumitomo Chemical Co Ltd 第四級アンモニウム塩の製造方法
JP4799892B2 (ja) * 2005-03-31 2011-10-26 住友化学株式会社 シクロヘキサン誘導体およびその製造方法
DK1884242T3 (da) * 2005-05-26 2013-05-06 Dainippon Sumitomo Pharma Co Farmaceutisk sammensætning omfattende lurasidon
WO2006134864A1 (ja) * 2005-06-13 2006-12-21 Dainippon Sumitomo Pharma Co., Ltd. 可溶化型製剤
AU2008236705B2 (en) 2007-04-04 2014-01-23 Merck Sharp & Dohme Corp. Therapeutic agents
US20090076027A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched lurasidone
JP5401327B2 (ja) 2008-02-11 2014-01-29 大日本住友製薬株式会社 溶出性の改善された錠剤
US20110003994A1 (en) 2009-07-02 2011-01-06 Dainippon Sumitomo Pharma Co., Ltd. Cycloalkane derivative
US20110124659A1 (en) * 2009-11-17 2011-05-26 Dainippon Sumitomo Pharma Co., Ltd. Cycloalkane derivative
JP5317939B2 (ja) * 2009-12-02 2013-10-16 住友化学株式会社 アルコール化合物の製造方法
WO2011093522A1 (en) * 2010-01-28 2011-08-04 Dainippon Sumitomo Pharma Co., Ltd. A cycloalkane derivative
US8735397B2 (en) 2010-03-29 2014-05-27 Vanderbilt University Method for treating schizophrenia and related diseases
WO2011136384A1 (en) 2010-04-26 2011-11-03 Dainippon Sumitomo Pharma Co., Ltd. A process of a quaternary ammonium salt using phosphate
HUE030294T2 (en) 2010-04-26 2017-04-28 Sumitomo Dainippon Pharma Co Ltd A method for preparing a quaternary ammonium salt
CN107595771A (zh) * 2010-10-18 2018-01-19 大日本住友制药株式会社 注射用缓释制剂
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
DK3034079T3 (en) 2010-11-15 2018-02-05 Agenebio Inc PYRIDAZINE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR TREATING COGNITIVE WEAKNESS
WO2012107890A2 (en) * 2011-02-10 2012-08-16 Ranbaxy Laboratories Limited Crystalline forms of lurasidone hydrochloride
WO2012123858A1 (en) 2011-03-14 2012-09-20 Ranbaxy Laboratories Limited Amorphous lurasidone hydrochloride
US9034867B2 (en) 2011-03-18 2015-05-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising sorbitan esters
CA2831703A1 (en) 2011-04-01 2012-10-04 Ranbaxy Laboratories Limited Process for the preparation of an antipsychotic agent
CN102731512B (zh) * 2011-04-12 2015-04-22 天津药物研究院 一种鲁拉西酮中间体及鲁拉西酮的制备方法
US9433620B2 (en) 2011-05-13 2016-09-06 Cadila Healthcare Limited Pharmaceutical compositions of lurasidone
WO2013014665A1 (en) * 2011-07-28 2013-01-31 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN102911169B (zh) * 2011-08-02 2015-05-06 上海医药工业研究院 一种卢拉西酮的制备方法
WO2013030722A1 (en) 2011-08-26 2013-03-07 Ranbaxy Laboratories Limited Crystalline lurasidone hydrochloride
CN103130795A (zh) * 2011-12-02 2013-06-05 苏州二叶制药有限公司 卢拉西酮盐酸盐的晶体a及其用途
CN103130794B (zh) * 2011-12-02 2016-06-22 苏州二叶制药有限公司 卢拉西酮盐酸盐的晶体a的制备方法
WO2013121440A1 (en) 2012-02-13 2013-08-22 Cadila Healthcare Limited Process for preparing benzisothiazol-3-yl-peperazin-l-yl-methyl-cyclo hexyl-methanisoindol-1,3-dione and its intermediates
JP6219918B2 (ja) * 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
WO2013142198A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaaceutical compositions comprising fatty acid esters
WO2013142205A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
CN103360383B (zh) * 2012-04-11 2016-07-06 上海医药工业研究院 鲁拉西酮盐酸盐的晶型b及其制备方法
US10052319B2 (en) 2012-04-26 2018-08-21 Sumitomo Dainippon Pharma Co., Ltd. Medicament for treating mental and behavioural disorders
CN102746289B (zh) * 2012-04-28 2016-06-08 上海医药工业研究院 一种盐酸卢拉西酮的制备方法
CN103450172A (zh) * 2012-05-30 2013-12-18 广州药源生物医药科技有限公司 一种抗精神病药物鲁拉西酮的制备方法
WO2013190455A2 (en) * 2012-06-18 2013-12-27 Shasun Pharmaceuticals Limited Process for the preparation of lurasidone hydrochloride
US9580414B2 (en) * 2012-07-18 2017-02-28 Shasun Pharmaceuticals Limited Salts and hydrates of antipsychotics
WO2014037886A1 (en) 2012-09-04 2014-03-13 Ranbaxy Laboratories Limited Process for the preparation of lurasidone hydrochloride
EP3718536A1 (de) 2012-09-19 2020-10-07 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit verbesserter lagerstabilität
CN102827157A (zh) * 2012-09-20 2012-12-19 北京哈三联科技股份有限公司 一种制备鲁拉西酮的方法
WO2014064714A2 (en) * 2012-10-22 2014-05-01 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of lurasidone hydrochloride
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103864774B (zh) * 2012-12-14 2016-09-28 成都弘达药业有限公司 一种鲁拉西酮的制备方法
WO2014102808A1 (en) 2012-12-25 2014-07-03 Lee Pharma Limited A process for preparation of trans (lr,2r)-cyclo hexane 1, 2-dicarboxylic acid
WO2014102834A2 (en) * 2012-12-31 2014-07-03 Hetero Research Foundation Process for lurasidone
ITMI20130262A1 (it) * 2013-02-22 2014-08-23 Edmond Pharma Srl Procedimento per la preparazione di lurasidone cloridrato
CN109705112A (zh) * 2013-03-06 2019-05-03 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型的制备方法
CN104513182A (zh) * 2013-10-08 2015-04-15 无锡万全医药技术有限公司 一种(1r,2r)-1,2-环己烷二甲醇二磺酸酯的制备方法
ITMI20131737A1 (it) 2013-10-17 2015-04-18 Procos Spa Processo per la sintesi industriale di lurasidone
CZ306203B6 (cs) 2013-12-06 2016-09-29 Zentiva, K. S Způsob syntézy lurasidonu
CN112409363B (zh) 2013-12-20 2023-11-14 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂䓬衍生物、组合物和方法
EP3119399A4 (de) 2014-03-20 2017-09-27 Alkermes Pharma Ireland Limited Aripiprazolformulierungen mit erhöhten injektionsgeschwindigkeiten
CA2951917C (en) 2014-06-16 2019-09-24 Johnson Matthey Public Limited Company Processes for making alkylated arylpiperazine and alkylated arylpiperidine compounds including novel intermediates
WO2016012898A1 (en) 2014-07-25 2016-01-28 Lupin Limited Oral pharmaceutical composition of lurasidone
WO2016059649A1 (en) 2014-10-14 2016-04-21 Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) An improved process for the preparation of lurasidone hydrochloride
CN113185508A (zh) * 2015-04-21 2021-07-30 上海医药集团股份有限公司 一种制备高纯度高收率鲁拉西酮的方法
WO2016205739A1 (en) 2015-06-19 2016-12-22 Belew Mekonnen Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2018015915A1 (en) 2016-07-22 2018-01-25 Cadila Healthcare Limited A parenteral controlled release composition of an atypical antipsychotic agent
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110114063B (zh) 2017-01-06 2022-01-11 广东东阳光药业有限公司 鲁拉西酮固体分散体及其制备方法
JPWO2019167977A1 (ja) 2018-02-28 2021-02-04 大日本住友製薬株式会社 水性懸濁型医薬製剤
SG11202008233WA (en) 2018-02-28 2020-09-29 Sumitomo Dainippon Pharma Co Ltd Aqueous suspension pharmaceutical preparation with controlled dissolution
CA3092335A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
BR112020026062B1 (pt) 2018-06-19 2023-04-04 Agenebio, Inc Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson
CN113024535B (zh) 2019-12-24 2024-08-02 上海科胜药物研发有限公司 一种鲁拉西酮盐酸盐的制备方法
CA3245085A1 (en) 2022-01-11 2023-07-20 Suven Life Sciences Limited HETEROCYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
US20240132513A1 (en) 2022-08-19 2024-04-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN117285530B (zh) * 2023-08-03 2026-01-16 迪嘉药业集团股份有限公司 一种盐酸鲁拉西酮新制备方法
WO2026089567A1 (ko) * 2024-10-25 2026-04-30 주식회사 비보존 헤테로사이클 화합물 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
EP0009465A1 (de) * 1978-09-20 1980-04-02 Ciba-Geigy Ag N-(1-(4-Amino-2-chinazolinyl)-3- oder -4-piperidyl-lactame, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate enthaltend diese Verbindungen
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
HUT36793A (en) * 1983-06-27 1985-10-28 Sandoz Ag Process for producing new spirosuccunimide derivatives and pharmaceutical composition containing them
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use

Also Published As

Publication number Publication date
DE69129282T4 (de) 2011-01-13
CA2046429A1 (en) 1992-01-07
CA2046429C (en) 2003-09-16
ES2115599T3 (es) 1998-07-01
GR3026697T3 (en) 1998-07-31
EP0464846B1 (de) 1998-04-22
US5532372A (en) 1996-07-02
EP0464846A1 (de) 1992-01-08
DK0464846T3 (da) 1998-11-30
DE69129282D1 (de) 1998-05-28
JP2800953B2 (ja) 1998-09-21
DE69129282T2 (de) 1998-08-20
JPH0517440A (ja) 1993-01-26
US5780632A (en) 1998-07-14

Similar Documents

Publication Publication Date Title
DE69129282D1 (de) Imidderivate, ihre Herstellung und Verwendung
ATE117295T1 (de) 4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
ATE82272T1 (de) Lipid-derivate, ihre herstellung und verwendung.
ATE117681T1 (de) Chinolinderivate, ihre herstellung und verwendung.
JPS55164678A (en) Novel cyclic imidazolecyanoguanidine
DE68905407D1 (de) Analgetische carbonsaeureamid-derivate.
FI953710A0 (fi) Uusia pyrrolokarbatsoleja
DE69401136D1 (de) Modifizierte Oligodeoxyribonukleotide, ihre Herstellung und ihre therapeutische Verwendung
ATE207058T1 (de) Amine derivate, ihre herstellung und anwendung
EP0485219A3 (en) Medicaments for preventing and treating circulatory organ diseases containing spiro-3-heteroazolidine compounds
ATE119156T1 (de) N-acryloylpiperazin-derivate, deren herstellung und deren verwendung als paf-antagonisten.
ATE71370T1 (de) 2-amino-5-hydroxy-4-pyrimidone.
DE3869194D1 (de) Fungizide.
DE69105865D1 (de) Biphenyl-5,5'-bis-Alkansäurederivate, deren Herstellung und Verwendung.
DE69526332D1 (de) Indol-derivate
ATE198194T1 (de) Azetidinonderivate für die herstellung von carbapenemantibiotika
IT1217900B (it) Composti eterociclici azotati ad azione antifungina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time