ATE161264T1 - Tieftemperatur-verfahren zur herstellung von mit alpha-anomeren angereicherten 2-deoxy-2,2-difluor-d-ribofuranosyl-sulfonaten - Google Patents

Tieftemperatur-verfahren zur herstellung von mit alpha-anomeren angereicherten 2-deoxy-2,2-difluor-d-ribofuranosyl-sulfonaten

Info

Publication number
ATE161264T1
ATE161264T1 AT93304818T AT93304818T ATE161264T1 AT E161264 T1 ATE161264 T1 AT E161264T1 AT 93304818 T AT93304818 T AT 93304818T AT 93304818 T AT93304818 T AT 93304818T AT E161264 T1 ATE161264 T1 AT E161264T1
Authority
AT
Austria
Prior art keywords
deoxy
difluoro
low temperature
temperature process
anomer enriched
Prior art date
Application number
AT93304818T
Other languages
German (de)
English (en)
Inventor
Ta-Sen Chou
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25415642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE161264(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE161264T1 publication Critical patent/ATE161264T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93304818T 1992-06-22 1993-06-21 Tieftemperatur-verfahren zur herstellung von mit alpha-anomeren angereicherten 2-deoxy-2,2-difluor-d-ribofuranosyl-sulfonaten ATE161264T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,301 US5401861A (en) 1992-06-22 1992-06-22 Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (1)

Publication Number Publication Date
ATE161264T1 true ATE161264T1 (de) 1998-01-15

Family

ID=25415642

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93304818T ATE161264T1 (de) 1992-06-22 1993-06-21 Tieftemperatur-verfahren zur herstellung von mit alpha-anomeren angereicherten 2-deoxy-2,2-difluor-d-ribofuranosyl-sulfonaten

Country Status (15)

Country Link
US (1) US5401861A (OSRAM)
EP (1) EP0576229B1 (OSRAM)
JP (1) JP3379994B2 (OSRAM)
KR (1) KR100312389B1 (OSRAM)
AT (1) ATE161264T1 (OSRAM)
BR (1) BR9302428A (OSRAM)
CA (1) CA2098886C (OSRAM)
DE (1) DE69315752T2 (OSRAM)
DK (1) DK0576229T3 (OSRAM)
ES (1) ES2112389T3 (OSRAM)
GR (1) GR3026210T3 (OSRAM)
HU (1) HU216840B (OSRAM)
IL (1) IL106076A (OSRAM)
MX (1) MX9303710A (OSRAM)
TW (1) TW233299B (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) * 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
JP2005533824A (ja) * 2002-06-28 2005-11-10 イデニクス（ケイマン）リミテツド フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7824851B2 (en) * 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
EP1585529A4 (en) * 2002-12-12 2008-05-28 Idenix Cayman Ltd PROCESS FOR PREPARING 2'-BRANCHED NUCLEOSIDES
JP2008503562A (ja) * 2004-06-23 2008-02-07 イデニクス（ケイマン）リミテツド フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
BRPI0513783A (pt) 2004-07-29 2008-05-13 Hanmi Pharm Ind Co Ltd derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
AU2005320374B2 (en) * 2004-12-30 2009-01-08 Hanmi Science Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
ATE458743T1 (de) * 2005-03-04 2010-03-15 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
KR101171087B1 (ko) * 2005-06-03 2012-08-06 조오지 슐로에머 알파-아노머가 풍부한 2-데옥시-2,2-디플루오로-ｄ-리보푸라노실 설포네이트 및 베타 뉴클레오시드 제조를 위한 이들의 용도
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
CA2634749C (en) * 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
KR101357409B1 (ko) 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
ES2131152T3 (es) * 1987-08-28 1999-07-16 Lilly Co Eli Procedimiento para aislar selectivamente beta-2'-desoxi-2',2'-difluorocitidina o sus sales.

Also Published As

Publication number Publication date
DE69315752T2 (de) 1998-04-23
EP0576229A1 (en) 1993-12-29
KR940005655A (ko) 1994-03-22
IL106076A0 (en) 1993-10-20
HU9301827D0 (en) 1993-09-28
HU216840B (hu) 1999-09-28
TW233299B (OSRAM) 1994-11-01
HUT64552A (en) 1994-01-28
US5401861A (en) 1995-03-28
GR3026210T3 (en) 1998-05-29
CA2098886C (en) 2005-08-09
ES2112389T3 (es) 1998-04-01
DK0576229T3 (da) 1998-01-19
BR9302428A (pt) 1994-01-11
EP0576229B1 (en) 1997-12-17
IL106076A (en) 2002-02-10
JP3379994B2 (ja) 2003-02-24
KR100312389B1 (ko) 2002-06-20
CA2098886A1 (en) 1993-12-23
DE69315752D1 (de) 1998-01-29
MX9303710A (es) 1994-01-31
JPH0656866A (ja) 1994-03-01

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