ATE159532T1 - Verfahren zur reinigung von igg-monoklonalen antikörpern - Google Patents

Verfahren zur reinigung von igg-monoklonalen antikörpern

Info

Publication number
ATE159532T1
ATE159532T1 AT92108912T AT92108912T ATE159532T1 AT E159532 T1 ATE159532 T1 AT E159532T1 AT 92108912 T AT92108912 T AT 92108912T AT 92108912 T AT92108912 T AT 92108912T AT E159532 T1 ATE159532 T1 AT E159532T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
igg monoclonal
purifying igg
purifying
immunotherapy
Prior art date
Application number
AT92108912T
Other languages
German (de)
English (en)
Inventor
Norbert Dr Kothe
Dieter Dr Rudnick
Detlef Dr Rohm
Ulf Dr Bethke
Michael Dr Kloft
Original Assignee
Biotest Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Pharma Gmbh filed Critical Biotest Pharma Gmbh
Application granted granted Critical
Publication of ATE159532T1 publication Critical patent/ATE159532T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92108912T 1991-06-08 1992-05-27 Verfahren zur reinigung von igg-monoklonalen antikörpern ATE159532T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4118912A DE4118912C1 (https=) 1991-06-08 1991-06-08

Publications (1)

Publication Number Publication Date
ATE159532T1 true ATE159532T1 (de) 1997-11-15

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92108912T ATE159532T1 (de) 1991-06-08 1992-05-27 Verfahren zur reinigung von igg-monoklonalen antikörpern

Country Status (7)

Country Link
EP (1) EP0530447B1 (https=)
JP (1) JP2644946B2 (https=)
AT (1) ATE159532T1 (https=)
DE (2) DE4118912C1 (https=)
DK (1) DK0530447T3 (https=)
ES (1) ES2108059T3 (https=)
GR (1) GR3025603T3 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
IL140155A (en) * 1998-06-09 2005-12-18 Statens Seruminstitut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
JPWO2004087761A1 (ja) * 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
CN101679509A (zh) 2007-06-01 2010-03-24 弗·哈夫曼-拉罗切有限公司 免疫球蛋白纯化
AR067536A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
CL2008002053A1 (es) 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
JP2012513425A (ja) 2008-12-22 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 免疫グロブリンの精製
WO2011095543A1 (en) 2010-02-04 2011-08-11 Csl Behring Ag Immunoglobulin preparation
CN102762585B (zh) 2010-02-12 2016-01-20 DPx控股有限公司 单一单元抗体纯化
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
CN103118708B (zh) 2010-09-14 2015-08-26 霍夫曼-拉罗奇有限公司 用于纯化聚乙二醇化的促红细胞生成素的方法
AU2011325341B2 (en) * 2010-11-01 2015-12-17 Dpx Holdings B.V. Single unit ion exchange chromatography antibody purification
JP6116565B2 (ja) 2011-08-25 2017-04-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 陽イオンおよび陰イオン交換クロマトグラフィー法
EP2596812B1 (de) * 2011-11-22 2015-06-10 Heraeus Medical GmbH Sterilisation von polymerisierbaren Monomeren
KR101917196B1 (ko) * 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
ES2988823T3 (es) 2014-12-03 2024-11-21 Csl Behring Ag Producto farmacéutico con mayor estabilidad que comprende inmunoglobulinas
KR102470282B1 (ko) 2016-07-15 2022-11-24 에프. 호프만-라 로슈 아게 Ｐｅｇ화 에리트로포이에틴을 정제하기 위한 방법
JP2022523063A (ja) * 2019-01-30 2022-04-21 アムジエン・インコーポレーテツド アフリベルセプトの属性、並びにその特性決定及び修飾方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
GR3025603T3 (en) 1998-03-31
DK0530447T3 (da) 1998-01-12
DE59208982D1 (de) 1997-11-27
ES2108059T3 (es) 1997-12-16
JPH07267997A (ja) 1995-10-17
JP2644946B2 (ja) 1997-08-25
DE4118912C1 (https=) 1992-07-02
EP0530447A3 (en) 1993-08-18
EP0530447B1 (de) 1997-10-22
EP0530447A2 (de) 1993-03-10

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