ATE155525T1 - Verkürzte formen den hepatozyten wachstumsfaktor (hgf) rezeptors - Google Patents

Verkürzte formen den hepatozyten wachstumsfaktor (hgf) rezeptors

Info

Publication number
ATE155525T1
ATE155525T1 AT92909513T AT92909513T ATE155525T1 AT E155525 T1 ATE155525 T1 AT E155525T1 AT 92909513 T AT92909513 T AT 92909513T AT 92909513 T AT92909513 T AT 92909513T AT E155525 T1 ATE155525 T1 AT E155525T1
Authority
AT
Austria
Prior art keywords
growth factor
hepatocyte growth
hgf
receptor
chain
Prior art date
Application number
AT92909513T
Other languages
English (en)
Inventor
Paolo Comoglio
Tiziana Crepaldi
Maria Prat
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110202A external-priority patent/GB9110202D0/en
Priority claimed from GB919124896A external-priority patent/GB9124896D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE155525T1 publication Critical patent/ATE155525T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT92909513T 1991-05-10 1992-04-30 Verkürzte formen den hepatozyten wachstumsfaktor (hgf) rezeptors ATE155525T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110202A GB9110202D0 (en) 1991-05-10 1991-05-10 Truncated forms of the hepatocyte growth factor(hgf)receptor
GB919124896A GB9124896D0 (en) 1991-11-22 1991-11-22 Truncated forms of the hepatocyte growth factor(hgf)receptor

Publications (1)

Publication Number Publication Date
ATE155525T1 true ATE155525T1 (de) 1997-08-15

Family

ID=26298888

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92909513T ATE155525T1 (de) 1991-05-10 1992-04-30 Verkürzte formen den hepatozyten wachstumsfaktor (hgf) rezeptors

Country Status (18)

Country Link
US (1) US5571509A (de)
EP (2) EP0520158A1 (de)
JP (1) JP3293823B2 (de)
AT (1) ATE155525T1 (de)
AU (1) AU651452B2 (de)
CA (1) CA2102595C (de)
DE (1) DE69220940T2 (de)
DK (1) DK0584125T3 (de)
ES (1) ES2104914T3 (de)
FI (1) FI934934A (de)
GR (1) GR3024998T3 (de)
HU (1) HUT67009A (de)
IE (1) IE921485A1 (de)
IL (1) IL101809A0 (de)
MX (1) MX9202129A (de)
MY (1) MY108614A (de)
NZ (1) NZ242645A (de)
WO (1) WO1992020792A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344321B1 (en) * 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
WO1995001376A1 (en) * 1993-06-30 1995-01-12 Pharmacia S.P.A. Peptide inhibitors of mitogenesis and motogenesis
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5855918A (en) * 1995-09-12 1999-01-05 Genentech, Inc. Cystic fibrosis therapy
AU7254896A (en) * 1995-10-05 1997-04-28 Genentech Inc. Improved angiogenesis using hepatocyte growth factor
WO1997012628A1 (en) * 1995-10-05 1997-04-10 Genentech, Inc. Methods and compositions for treating vascular stenosis
WO1998000543A1 (en) * 1996-07-03 1998-01-08 Genentech, Inc. Hepatocyte growth factor receptor agonists and uses thereof
US5874306A (en) * 1996-12-12 1999-02-23 The Regents Of The University Of California Culturing human pancreatic endocrine cells in medium containing extracellular matrix from human bladder carcinoma cells
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6031155A (en) * 1997-06-05 2000-02-29 Cameron-Mills; Verena Arabinoxylan degradation
AU2760602A (en) * 2001-03-23 2002-09-26 Agouron Pharmaceuticals, Inc. Catalytic domains of the human hepatocyte growth factor receptor tyrosine kinase, and materials and methods for identification of inhibitors thereof
US20030118585A1 (en) 2001-10-17 2003-06-26 Agy Therapeutics Use of protein biomolecular targets in the treatment and visualization of brain tumors
US7678769B2 (en) * 2001-09-14 2010-03-16 Compugen, Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
US20040248157A1 (en) * 2001-09-14 2004-12-09 Michal Ayalon-Soffer Novel polynucleotides encoding soluble polypeptides and methods using same
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20100183573A1 (en) * 2001-09-14 2010-07-22 Compugen Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
ITMI20031127A1 (it) 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
KR20110117728A (ko) * 2003-06-06 2011-10-27 제넨테크, 인크. Ｈｇｆ 베타 쇄와 ｃ-ｍｅｔ 사이의 상호작용의 변조
EP2336178A1 (de) * 2003-12-11 2011-06-22 Genentech, Inc. Verfahren und Produkt um c-Met-Dimerisierung und -Aktivierung zu verhindern
AU2005206388A1 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods and systems for annotating biomolecular sequences
AU2005206389A1 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby
WO2006015371A2 (en) 2004-08-05 2006-02-09 Genentech, Inc. Humanized anti-cmet antagonists
EP1869070B1 (de) 2005-04-15 2013-11-27 Genentech, Inc. Hgf-beta-kettenvarianten
US7758862B2 (en) * 2005-09-30 2010-07-20 Compugen Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
JP5536445B2 (ja) 2006-03-30 2014-07-02 ノバルティス アーゲー ｃ−Ｍｅｔの抗体の組成物およびその使用方法
AU2009208607B2 (en) * 2008-01-31 2013-08-01 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
IL198545A0 (en) 2008-05-14 2011-07-31 Metheresis Translational Res Sa High affinity binding site of hgfr and methods for identification of antagonists thereof
PA8849001A1 (es) 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
KR101671378B1 (ko) * 2009-10-30 2016-11-01 삼성전자 주식회사 ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그의 용도
JP2013532627A (ja) 2010-07-01 2013-08-19 武田薬品工業株式会社 ｃＭＥＴ阻害剤とＨＧＦおよび／またはｃＭＥＴに対する抗体との組み合わせ
US20130004484A1 (en) 2011-06-30 2013-01-03 Genentech, Inc. Anti-c-met antibody formulations
WO2013043452A1 (en) 2011-09-20 2013-03-28 Eli Lilly And Company Anti-c-met antibodies
CN107002119A (zh) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648273A (en) * 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
EP0507868A4 (en) * 1989-12-27 1992-11-04 Us Commerce Diagnostic probe for detecting human stomach cancer

Also Published As

Publication number Publication date
HUT67009A (en) 1995-01-30
FI934934A0 (fi) 1993-11-08
DE69220940T2 (de) 1998-01-15
DK0584125T3 (da) 1997-09-08
HU9303182D0 (en) 1994-03-28
JPH06508508A (ja) 1994-09-29
IL101809A0 (en) 1992-12-30
EP0584125B1 (de) 1997-07-16
AU651452B2 (en) 1994-07-21
WO1992020792A1 (en) 1992-11-26
GR3024998T3 (en) 1998-01-30
NZ242645A (en) 1994-11-25
DE69220940D1 (de) 1997-08-21
ES2104914T3 (es) 1997-10-16
EP0520158A1 (de) 1992-12-30
CA2102595C (en) 2003-01-14
US5571509A (en) 1996-11-05
CA2102595A1 (en) 1992-11-11
AU1672092A (en) 1992-12-30
IE921485A1 (en) 1992-11-18
FI934934A (fi) 1994-01-05
MY108614A (en) 1996-10-31
MX9202129A (es) 1992-11-01
JP3293823B2 (ja) 2002-06-17
EP0584125A1 (de) 1994-03-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee