ATE154756T1 - Verfahren zur herstellung von pellets mit verzögerter freisetzung - Google Patents

Verfahren zur herstellung von pellets mit verzögerter freisetzung

Info

Publication number
ATE154756T1
ATE154756T1 AT93908213T AT93908213T ATE154756T1 AT E154756 T1 ATE154756 T1 AT E154756T1 AT 93908213 T AT93908213 T AT 93908213T AT 93908213 T AT93908213 T AT 93908213T AT E154756 T1 ATE154756 T1 AT E154756T1
Authority
AT
Austria
Prior art keywords
pct
binder
sustained release
release pellets
sec
Prior art date
Application number
AT93908213T
Other languages
English (en)
Inventor
Henning G Kristensen
Torben Schaefer
Lars Juul Thomsen
Arne Kristensen
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Application granted granted Critical
Publication of ATE154756T1 publication Critical patent/ATE154756T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Disintegrating Or Milling (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT93908213T 1992-03-20 1993-03-16 Verfahren zur herstellung von pellets mit verzögerter freisetzung ATE154756T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9200858A SE9200858L (sv) 1992-03-20 1992-03-20 Metod för framställning av pellets med fördröjd frisättning

Publications (1)

Publication Number Publication Date
ATE154756T1 true ATE154756T1 (de) 1997-07-15

Family

ID=20385679

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908213T ATE154756T1 (de) 1992-03-20 1993-03-16 Verfahren zur herstellung von pellets mit verzögerter freisetzung

Country Status (12)

Country Link
US (1) US5807583A (de)
EP (1) EP0630235B1 (de)
JP (1) JPH07505360A (de)
AT (1) ATE154756T1 (de)
AU (1) AU675062B2 (de)
CA (1) CA2132451C (de)
DE (1) DE69311800T2 (de)
DK (1) DK0630235T3 (de)
ES (1) ES2105240T3 (de)
GR (1) GR3024604T3 (de)
SE (1) SE9200858L (de)
WO (1) WO1993018753A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
GB2284760B (en) * 1993-11-23 1998-06-24 Euro Celtique Sa A method of preparing pharmaceutical compositions by melt pelletisation
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
IL109460A (en) * 1993-05-10 1998-03-10 Euro Celtique Sa Controlled release formulation comprising tramadol
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US5690959A (en) * 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
IL109944A (en) * 1993-07-01 1998-12-06 Euro Celtique Sa Continuous release dosage form containing morphine and a method of preparing such sustained release unit dosage forms
PT654263E (pt) * 1993-11-23 2002-06-28 Euro Celtique Sa Metodo para a preparacao de uma composicao de libertyacao prolongada
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
EP0672416A1 (de) * 1994-03-14 1995-09-20 Euro-Celtique S.A. Diamorphin enthaltendes Arzneimittel
GB9422154D0 (en) † 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5827537A (en) * 1995-05-04 1998-10-27 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
GB9519363D0 (en) * 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19705538C1 (de) * 1997-02-14 1998-08-27 Goedecke Ag Verfahren zur Trennung von Wirkstoffen in festen pharmazeutischen Zubereitungen
DE19729487A1 (de) * 1997-07-10 1999-01-14 Dresden Arzneimittel Verfahren zur Herstellung von Wirkstoff-Zubereitungen mit kontrollierter Freisetzung aus einer Matrix
WO1999013864A2 (en) * 1997-09-19 1999-03-25 Shire Laboratories, Inc. Solid solution beadlet
DK173431B1 (da) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR20020059653A (ko) 1999-10-29 2002-07-13 그린 마틴, 브라이언 쥐 테슬리 서방성 하이드로코돈 제형
US6953593B2 (en) * 2000-02-01 2005-10-11 Lipoprotein Technologies, Inc. Sustained-release microencapsulated delivery system
KR100713234B1 (ko) * 2000-10-02 2007-05-02 유에스브이 리미티드 메트포민을 함유하는 지속방출형 약학 조성물 및 이의제조방법
PT1195160E (pt) 2000-10-05 2009-12-07 Usv Ltd Composições farmacêuticas de trimetazidina de libertação sustentada e método para a sua preparação
HU230686B1 (en) 2000-10-30 2017-08-28 Euro Celtique Sa Controlled release hydrocodone compositions
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
DE10300325A1 (de) 2003-01-09 2004-07-22 Hexal Ag Granulat mit öliger Substanz, Herstellungsverfahren und Tablette
US20060153915A1 (en) * 2003-01-23 2006-07-13 Amorepacific Corporation Sustained-release preparations and method for producing the same
US8034605B2 (en) * 2003-03-26 2011-10-11 Kyu-Jin Yum Microbial materials for degradation of oils and toxic chemicals
KR100412759B1 (en) * 2003-03-26 2004-01-07 Kyu Jin Yum Microbial preparation for decomposing oils and toxic chemicals
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
WO2005019163A2 (en) 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2371815A1 (de) 2003-12-30 2011-10-05 XenoPort, Inc. Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenverbindungen davon
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
US20050245614A1 (en) * 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
EP1753405A4 (de) * 2004-06-10 2008-09-17 Glatt Air Tech Inc Pharmazeutische formulierung mit kontrollierter freisetzung
US9034373B2 (en) * 2006-03-16 2015-05-19 Euro-Celtique S.A. Pharmaceutical spheroids
ES2674681T3 (es) 2007-02-20 2018-07-03 Allergan Pharmaceuticals International Limited Composiciones estables de enzimas digestivas
ES2350029T3 (es) * 2007-03-02 2011-01-17 Farnam Companies, Inc. Pellets de liberación sostenida que comprenden un material tipo cera.
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
KR20140019292A (ko) 2010-10-01 2014-02-14 아프탈리스 파르마 리미티드 장용 코팅된 저 강도 췌장 리파제 제제
WO2013021359A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
WO2013090452A1 (en) * 2011-12-12 2013-06-20 Orbis Biosciences, Inc. Sustained release particle formulations
WO2015020943A2 (en) 2013-08-09 2015-02-12 Aptalis Pharma Ltd. Digestive enzyme composition suitable for enteral administration
CA2944900C (en) 2014-04-04 2023-02-28 Pharmaquest International Center, LLC Disintegrating monolithic modified release tablets containing quadri-layer extended release granules
WO2015193730A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
DE2360796B2 (de) * 1973-12-06 1977-06-02 Edelfettwerke Werner Schlüter, 2000 Hamburg; Glyco Iberica S.A., Gava, Barcelona (Spanien) Vti: Hegel, K.Th., Dr.; Dickel, K., Dipl.-Ing.; Pat.-Anwälte, 2000 Hamburg und 8000 München Arzneimittel mit verzoegerter abgabe des wirkstoffs im darm
US5008112A (en) * 1985-12-16 1991-04-16 International Minerals & Chem. Corporation Device for the extended delivery of diffusible agents
DE3721721C1 (de) * 1987-07-01 1988-06-09 Hoechst Ag Verfahren zur Umhuellung von Granulaten
JP2681373B2 (ja) * 1988-07-18 1997-11-26 塩野義製薬株式会社 徐放性製剤の製造法
DK161743C (da) * 1989-07-03 1992-02-17 Niro Atomizer As Fremgangsmaade og apparat til agglomerering af et pulverformigt materiale
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
US5358560A (en) * 1991-10-04 1994-10-25 Eastman Chemical Company Solid-form additive systems dispersible in aqueous media and method for their preparation

Also Published As

Publication number Publication date
AU675062B2 (en) 1997-01-23
SE9200858D0 (sv) 1992-03-20
DE69311800D1 (de) 1997-07-31
JPH07505360A (ja) 1995-06-15
AU3911193A (en) 1993-10-21
CA2132451A1 (en) 1993-09-30
ES2105240T3 (es) 1997-10-16
DE69311800T2 (de) 1998-01-08
DK0630235T3 (da) 1998-02-02
CA2132451C (en) 2003-06-10
GR3024604T3 (en) 1997-12-31
WO1993018753A1 (en) 1993-09-30
EP0630235A1 (de) 1994-12-28
SE9200858L (sv) 1993-09-21
US5807583A (en) 1998-09-15
EP0630235B1 (de) 1997-06-25

Similar Documents

Publication Publication Date Title
ATE154756T1 (de) Verfahren zur herstellung von pellets mit verzögerter freisetzung
DE69509671D1 (de) Pharmazeutische zusammensetzung mit einem schmelzbaren traegermaterial und verfahren zu seiner herstellung
ATE18511T1 (de) Verfahren zur zerstaeubungs-mikroeinkapselung und dazu verwendbare zusammensetzung.
ATE35422T1 (de) Verfahren zur herstellung von pigmentzusammensetzungen.
ATE131727T1 (de) Verfahren zur arzneiformulierung sowie arzneimittel
ATE99268T1 (de) Verfahren zur herstellung von agglomeraten von aktiviertem aluminiumoxid, auf diese weise hergestellte agglomerate und vorrichtung zu ihrer herstellung.
DE3762862D1 (de) Verfahren zum agglomerieren von latex, so erhaltene agglomerierte latex und deren verwendung zum modifizieren und stossfestmachen von thermoplastischen matritzen.
JPS5561798A (en) Preparation of novel recombination dna
WO1999031141A3 (de) Verfahren zur herstellung von regulären porösen perlcellulosen, die perlcellulosen und ihre verwendung
ATE189188T1 (de) Verfahren zur herstellung von anorganische oxyde enthaltenden materialien mit monodisperser teilchengrösse und resultierende materialien
DE69229395D1 (de) Verfahren zur herstellung von polymerzusammensetzungen
ATE426337T1 (de) Verfahren zur herstellung von methionin-haltigen granulaten
ATE250410T1 (de) Verfahren zur herstellung von wirkstoff- zubereitungen mit kontrollierter freisetzung aus einer matrix
MX9206420A (es) Procedimiento para aglomerar material en particulas y productos hechos a partir de dicho procedimiento.
GEP19981475B (en) Solid Group Preparation for Shielding of ultivated Plants and Method for Its Production
DE837104C (de) Verfahren zur Herstellung von granuliertem Superphosphat
BR9607678A (pt) Novos concentrados aditivos
DE69525620D1 (de) Verfahren für die herstellung schmelz-granulierte sucralfatzubereitung
ATE133882T1 (de) Verfahren zur herstellung von verstärktem verbundmaterial sowie daraus hergestelltes produkt
DE69004215D1 (de) Bindemittel und Bindemittelzusammenstellung für das Agglomerieren von feinteiligen Stoffen, so erhaltene Agglomerate und Verfahren zu ihrer Herstellung.
ATE305491T1 (de) Verfahren zur herstellung von produkten enthaltend mineralteilchen und asphaltenhaltiges bindemittel
DE854324C (de) Agglomerierverfahren, insbesondere anwendbar bei der Verarbeitung keramischer Massen
DE2011132A1 (en) Urea and methyl cellulose-contng adhesives
ATE56752T1 (de) Verfahren zur herstellung einer poroesen struktur, die eine in einem bindemittel ausgestreute organische substanz enthaelt.
DE2101288A1 (en) Fertilizer mixts from nitrogenous wastes prepn - by enrichment with phosphoric acid soln

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification