ATE150000T1 - Einfluss von n,n,n-trimethylsphingosin auf die aktivität der protein-c-kinase, melanomzellwachstum in vitro, metastatisches potential in vivo und humane blutblättchenaggregation - Google Patents

Einfluss von n,n,n-trimethylsphingosin auf die aktivität der protein-c-kinase, melanomzellwachstum in vitro, metastatisches potential in vivo und humane blutblättchenaggregation

Info

Publication number
ATE150000T1
ATE150000T1 AT92902672T AT92902672T ATE150000T1 AT E150000 T1 ATE150000 T1 AT E150000T1 AT 92902672 T AT92902672 T AT 92902672T AT 92902672 T AT92902672 T AT 92902672T AT E150000 T1 ATE150000 T1 AT E150000T1
Authority
AT
Austria
Prior art keywords
pct
trimethylsphingosine
kinase
vitro
vivo
Prior art date
Application number
AT92902672T
Other languages
English (en)
Inventor
Satoshi Kimura
Yasyuki Igarashi
Sen-Itiroh Hakomori
Mahammed N Ahmad
Hirofumi Okoshi
Kazuko Handa
Original Assignee
Oncomembrane Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/636,353 external-priority patent/US5137919A/en
Application filed by Oncomembrane Inc filed Critical Oncomembrane Inc
Application granted granted Critical
Publication of ATE150000T1 publication Critical patent/ATE150000T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT92902672T 1990-12-31 1991-12-23 Einfluss von n,n,n-trimethylsphingosin auf die aktivität der protein-c-kinase, melanomzellwachstum in vitro, metastatisches potential in vivo und humane blutblättchenaggregation ATE150000T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/636,353 US5137919A (en) 1990-12-31 1990-12-31 Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US07/724,625 US5151360A (en) 1990-12-31 1991-07-02 Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation

Publications (1)

Publication Number Publication Date
ATE150000T1 true ATE150000T1 (de) 1997-03-15

Family

ID=27092583

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92902672T ATE150000T1 (de) 1990-12-31 1991-12-23 Einfluss von n,n,n-trimethylsphingosin auf die aktivität der protein-c-kinase, melanomzellwachstum in vitro, metastatisches potential in vivo und humane blutblättchenaggregation

Country Status (10)

Country Link
US (2) US5151360A (de)
EP (1) EP0565587B1 (de)
JP (1) JPH06504052A (de)
AT (1) ATE150000T1 (de)
CA (1) CA2097324A1 (de)
DE (1) DE69125185T2 (de)
DK (1) DK0565587T3 (de)
ES (1) ES2100333T3 (de)
GR (1) GR3023511T3 (de)
WO (1) WO1992012119A1 (de)

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DE69333924T2 (de) * 1992-05-29 2006-08-17 University Of North Carolina At Chapel Hill Im immobilisierten Zustand getrocknete pharmazeutisch verträgliche menschliche Blutplättchen
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US5587459A (en) * 1994-08-19 1996-12-24 Regents Of The University Of Minnesota Immunoconjugates comprising tyrosine kinase inhibitors
EP0754053A1 (de) * 1995-02-03 1997-01-22 Korea Institute of Science and Technology Neuartige blutstillende zusammensetzung
EP0888458A4 (de) * 1996-02-20 2004-05-06 Sloan Kettering Institutefor C Kombination von pkc-inhibitoren und therapeutischen agenzien zur behandlung von krebs
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CA2007507C (en) * 1989-02-03 1998-05-19 Yasuyuki Igarashi Sphingosine and n-methyl-sphingosine as inhibitor of cell growth

Also Published As

Publication number Publication date
US5331014A (en) 1994-07-19
EP0565587A1 (de) 1993-10-20
US5151360A (en) 1992-09-29
CA2097324A1 (en) 1992-07-01
GR3023511T3 (en) 1997-08-29
ES2100333T3 (es) 1997-06-16
EP0565587B1 (de) 1997-03-12
DE69125185T2 (de) 1997-08-28
JPH06504052A (ja) 1994-05-12
EP0565587A4 (en) 1994-06-01
DK0565587T3 (da) 1997-09-22
DE69125185D1 (de) 1997-04-17
WO1992012119A1 (en) 1992-07-23

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