GR3023511T3 - THE EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE ON PROTEIN KINASE-C ACTIVITY; MELANOMA CELL GROWTH -i(IN VITRO); METASTATIC POTENTIAL -i(IN VIVO) AND HUMAN PLATELET AGGREGATION - Google Patents

THE EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE ON PROTEIN KINASE-C ACTIVITY; MELANOMA CELL GROWTH -i(IN VITRO); METASTATIC POTENTIAL -i(IN VIVO) AND HUMAN PLATELET AGGREGATION

Info

Publication number
GR3023511T3
GR3023511T3 GR970401158T GR970401158T GR3023511T3 GR 3023511 T3 GR3023511 T3 GR 3023511T3 GR 970401158 T GR970401158 T GR 970401158T GR 970401158 T GR970401158 T GR 970401158T GR 3023511 T3 GR3023511 T3 GR 3023511T3
Authority
GR
Greece
Prior art keywords
pct
trimethylsphingosine
platelet aggregation
vitro
vivo
Prior art date
Application number
GR970401158T
Other languages
English (en)
Inventor
Satoshi Kimura
Yasyuki Igarashi
Sen-Itiroh Hakomori
Mahammed N Ahmad
Hirofumi Okoshi
Kazuko Handa
Original Assignee
Biomembrane Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/636,353 external-priority patent/US5137919A/en
Application filed by Biomembrane Inst filed Critical Biomembrane Inst
Publication of GR3023511T3 publication Critical patent/GR3023511T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
GR970401158T 1990-12-31 1997-05-22 THE EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE ON PROTEIN KINASE-C ACTIVITY; MELANOMA CELL GROWTH -i(IN VITRO); METASTATIC POTENTIAL -i(IN VIVO) AND HUMAN PLATELET AGGREGATION GR3023511T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/636,353 US5137919A (en) 1990-12-31 1990-12-31 Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US07/724,625 US5151360A (en) 1990-12-31 1991-07-02 Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
PCT/US1991/009196 WO1992012119A1 (en) 1990-12-31 1991-12-23 The effect of n,n,n-trimethylsphingosine on protein kinase-c activity; melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation

Publications (1)

Publication Number Publication Date
GR3023511T3 true GR3023511T3 (en) 1997-08-29

Family

ID=27092583

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401158T GR3023511T3 (en) 1990-12-31 1997-05-22 THE EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE ON PROTEIN KINASE-C ACTIVITY; MELANOMA CELL GROWTH -i(IN VITRO); METASTATIC POTENTIAL -i(IN VIVO) AND HUMAN PLATELET AGGREGATION

Country Status (10)

Country Link
US (2) US5151360A (el)
EP (1) EP0565587B1 (el)
JP (1) JPH06504052A (el)
AT (1) ATE150000T1 (el)
CA (1) CA2097324A1 (el)
DE (1) DE69125185T2 (el)
DK (1) DK0565587T3 (el)
ES (1) ES2100333T3 (el)
GR (1) GR3023511T3 (el)
WO (1) WO1992012119A1 (el)

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WO1993023997A1 (en) * 1992-05-29 1993-12-09 The University Of North Carolina At Chapel Hill Pharmaceutically acceptable fixed-dried human blood platelets
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US6098631A (en) * 1998-01-21 2000-08-08 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disease
WO2001058266A1 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Therapeutic platelets and methods
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
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US6858383B2 (en) 2000-12-22 2005-02-22 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
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Also Published As

Publication number Publication date
US5331014A (en) 1994-07-19
CA2097324A1 (en) 1992-07-01
US5151360A (en) 1992-09-29
EP0565587A1 (en) 1993-10-20
DE69125185D1 (de) 1997-04-17
WO1992012119A1 (en) 1992-07-23
EP0565587B1 (en) 1997-03-12
ES2100333T3 (es) 1997-06-16
DE69125185T2 (de) 1997-08-28
DK0565587T3 (da) 1997-09-22
EP0565587A4 (en) 1994-06-01
ATE150000T1 (de) 1997-03-15
JPH06504052A (ja) 1994-05-12

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