ATE147161T1 - Ein hplc-lichtstreuungsdetektor für biopolymere - Google Patents

Ein hplc-lichtstreuungsdetektor für biopolymere

Info

Publication number
ATE147161T1
ATE147161T1 AT92900681T AT92900681T ATE147161T1 AT E147161 T1 ATE147161 T1 AT E147161T1 AT 92900681 T AT92900681 T AT 92900681T AT 92900681 T AT92900681 T AT 92900681T AT E147161 T1 ATE147161 T1 AT E147161T1
Authority
AT
Austria
Prior art keywords
detector
light
scattered
scattered light
data
Prior art date
Application number
AT92900681T
Other languages
English (en)
Inventor
Gavin D Dollinger
Robert L Cunico
Michael G Kunitani
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE147161T1 publication Critical patent/ATE147161T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4726—Detecting scatter at 90°
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
AT92900681T 1990-10-23 1991-10-23 Ein hplc-lichtstreuungsdetektor für biopolymere ATE147161T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/601,840 US5269937A (en) 1990-10-23 1990-10-23 HPLC light scattering detector for biopolymers

Publications (1)

Publication Number Publication Date
ATE147161T1 true ATE147161T1 (de) 1997-01-15

Family

ID=24408976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92900681T ATE147161T1 (de) 1990-10-23 1991-10-23 Ein hplc-lichtstreuungsdetektor für biopolymere

Country Status (9)

Country Link
US (1) US5269937A (de)
EP (1) EP0505564B1 (de)
JP (1) JP3253614B2 (de)
AT (1) ATE147161T1 (de)
CA (1) CA2072004C (de)
DE (2) DE505564T1 (de)
ES (1) ES2038572T1 (de)
GR (1) GR930300025T1 (de)
WO (1) WO1992007244A1 (de)

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US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
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US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
WO2006036182A2 (en) * 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
GB2422897A (en) 2005-02-02 2006-08-09 Pcme Ltd A monitor for monitoring particles flowing in a stack
US7630076B2 (en) * 2005-07-26 2009-12-08 University Of Connecticut Dual-detector systems and methods having utility in biomolecular measurements
US7923238B2 (en) * 2006-02-10 2011-04-12 Bio-Rad Laboratories, Inc. Multi-channel electroporation system
CN101432626B (zh) 2006-04-04 2013-06-19 神谷来克斯公司 用于肌钙蛋白分析的高灵敏系统和方法
US7838250B1 (en) * 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2007121363A2 (en) * 2006-04-13 2007-10-25 Mississippi State University An optical apparatus for simultaneously measuring the scattering and concentration signals of macromolecules in a flow cell
US7750605B2 (en) 2006-09-21 2010-07-06 Bio-Rad Laboratories, Inc. Controlling an electrical signal sent to a sample load using a pulse modulated resistance
US7576549B2 (en) * 2006-09-21 2009-08-18 Bio-Rad Laboratories, Inc. Methods for measuring sample resistance in electroporation
US7593101B2 (en) * 2007-04-10 2009-09-22 Schlumberger Technology Corporation High-pressure cross-polar microscopy cells having adjustable fluid passage and methods of use
WO2009025898A2 (en) * 2007-05-24 2009-02-26 The Research Foundation Of The State University Of New York Dual detector capillary waveguide biosensor and method for use thereof
AU2008276127A1 (en) * 2007-07-17 2009-01-22 Hach Company Spatial frequency optical measurement instrument and method
JP2011508219A (ja) 2007-12-19 2011-03-10 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
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AU2010259022B2 (en) * 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
US20110301053A1 (en) 2010-05-06 2011-12-08 Singulex, Inc. Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis
US9001319B2 (en) 2012-05-04 2015-04-07 Ecolab Usa Inc. Self-cleaning optical sensor
US10132736B2 (en) 2012-05-24 2018-11-20 Abbvie Inc. Methods for inspection of protein particles in a liquid beneficial agent
JP5891958B2 (ja) * 2012-06-01 2016-03-23 株式会社デンソー 液体成分センサ
JP6536034B2 (ja) * 2012-12-21 2019-07-03 ソニー株式会社 粒子検出装置及び粒子検出方法
GB201304631D0 (en) * 2013-03-14 2013-05-01 Malvern Instr Ltd Monomer detection in protein separation
JP6191477B2 (ja) * 2014-01-24 2017-09-06 株式会社島津製作所 粒子径測定装置及び粒子径測定方法
DE102014007355B3 (de) * 2014-05-19 2015-08-20 Particle Metrix Gmbh Verfahren der Partikel Tracking Aalyse mit Hilfe von Streulicht (PTA) und eine Vorrichtung zur Erfassung und Charakterisierung von Partikeln in Flüssigkeiten aller Art in der Größenordnung von Nanometern
US20150355147A1 (en) 2014-06-06 2015-12-10 Biogénesis Bagó Uruguay S.A. High throughput quantification and characterization of foot and mouth disease virus and products thereof
US9470625B1 (en) * 2015-05-28 2016-10-18 National Chung Cheng University Method of examining purity of dendrimers
US11119079B2 (en) * 2017-08-17 2021-09-14 Daylight Solutions, Inc. Liquid chromatography analyzer system with on-line analysis of eluting fractions
WO2019116015A1 (en) * 2017-12-11 2019-06-20 Malvern Panalytical Limited Determine particle size distribution by size exclusion chromatography
JP7123160B2 (ja) * 2018-10-30 2022-08-22 アルプスアルパイン株式会社 流路プレート、分析装置及び分析方法
US11965900B2 (en) * 2018-11-09 2024-04-23 Wyatt Technology, Llc Indicating a status of an analytical instrument on a screen of the analytical instrument
US12085495B2 (en) 2020-06-18 2024-09-10 Wyatt Technology, Llc Calculating molar mass values of components of and molar mass concentration values of conjugate molecules/particles
US20250137899A1 (en) * 2021-09-09 2025-05-01 Tosoh Bioscience Llc Light scattering detectors and methods for the same
CN116223403A (zh) * 2021-12-03 2023-06-06 北京航空航天大学 水和脂肪成分的浓度测量方法、系统、装置及电子设备
CN113916730B (zh) * 2021-12-13 2022-10-28 济南微纳颗粒仪器股份有限公司 一种纳米级粒度检测装置
US20240272066A1 (en) * 2023-02-15 2024-08-15 Zhenhong Yu Acoustic excitation device with dual-wavelength output
EP4542204A1 (de) * 2023-10-18 2025-04-23 École Polytechnique Fédérale de Lausanne (EPFL) Verfahren, computerlesbares medium und vorrichtung zur bestimmung eines aggregatzustands eines gelösten stoffes in einem lösungsmittel
EP4664105A1 (de) * 2024-06-10 2025-12-17 Malvern Panalytical Limited Flüssigkeitschromatographiedetektor

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Also Published As

Publication number Publication date
CA2072004A1 (en) 1992-04-24
EP0505564A1 (de) 1992-09-30
ES2038572T1 (es) 1993-08-01
DE69123957T2 (de) 1997-04-30
DE505564T1 (de) 1993-05-19
DE69123957D1 (de) 1997-02-13
GR930300025T1 (en) 1993-05-24
EP0505564B1 (de) 1997-01-02
WO1992007244A1 (en) 1992-04-30
CA2072004C (en) 2000-04-04
JPH05505882A (ja) 1993-08-26
JP3253614B2 (ja) 2002-02-04
US5269937A (en) 1993-12-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time