ATE146479T1 - Modifizierte oligodeoxyribonukleotide, ihre herstellung und ihre therapeutische verwendung - Google Patents

Modifizierte oligodeoxyribonukleotide, ihre herstellung und ihre therapeutische verwendung

Info

Publication number
ATE146479T1
ATE146479T1 AT94300675T AT94300675T ATE146479T1 AT E146479 T1 ATE146479 T1 AT E146479T1 AT 94300675 T AT94300675 T AT 94300675T AT 94300675 T AT94300675 T AT 94300675T AT E146479 T1 ATE146479 T1 AT E146479T1
Authority
AT
Austria
Prior art keywords
compounds
groups
sulfur
oxygen
preparation
Prior art date
Application number
AT94300675T
Other languages
English (en)
Inventor
Hidehiko Furukawa
Kenji Momota
Hitoshi Hotoda
Makoto Koizumi
Masakatsu Kaneko
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE146479T1 publication Critical patent/ATE146479T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT94300675T 1993-01-29 1994-01-28 Modifizierte oligodeoxyribonukleotide, ihre herstellung und ihre therapeutische verwendung ATE146479T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1350993 1993-01-29
JP13557393 1993-06-07
JP13851793 1993-06-10

Publications (1)

Publication Number Publication Date
ATE146479T1 true ATE146479T1 (de) 1997-01-15

Family

ID=27280283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94300675T ATE146479T1 (de) 1993-01-29 1994-01-28 Modifizierte oligodeoxyribonukleotide, ihre herstellung und ihre therapeutische verwendung

Country Status (19)

Country Link
US (2) US5674856A (de)
EP (1) EP0611075B1 (de)
KR (1) KR100318796B1 (de)
CN (2) CN1039014C (de)
AT (1) ATE146479T1 (de)
AU (1) AU670154B2 (de)
CA (1) CA2114355A1 (de)
CZ (1) CZ287050B6 (de)
DE (1) DE69401136T2 (de)
DK (1) DK0611075T3 (de)
ES (1) ES2098866T3 (de)
FI (1) FI111265B (de)
GR (1) GR3022821T3 (de)
HK (2) HK1000191A1 (de)
HU (1) HU222834B1 (de)
IL (1) IL108467A (de)
NO (1) NO309427B1 (de)
NZ (2) NZ250795A (de)
RU (1) RU2111971C1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
CN1060177C (zh) * 1997-06-28 2001-01-03 中国科学院上海生物化学研究所 3′－单磷酸化寡核苷酸
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6995259B1 (en) * 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
DE10041809A1 (de) * 2000-08-25 2002-03-07 Giesing Michael Arrays immobilisierter Biomoleküle, deren Herstellung und Verwendung
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) * 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
EP2511260B1 (de) * 2009-12-08 2015-07-29 Gifu University Aromatische verbindung, modifikationsträger damit und ihre verwendung zur synthese eines oligonukleotidderivats, oligonukleotidderivat und oligonukleotidkonstrukt
CN102766183B (zh) * 2011-05-05 2016-09-14 中国人民解放军军事医学科学院毒物药物研究所 具有抗hiv-1融合活性的修饰的核酸结构
CN116496335B (zh) * 2023-03-21 2024-03-08 中国药科大学 一种修饰核苷酸及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE56723T1 (de) * 1980-02-29 1990-10-15 University Patents Inc Verfahren zur herstellung von modifizierten anorganischen polymeren.
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
FR2568254B1 (fr) * 1984-07-25 1988-04-29 Centre Nat Rech Scient Application d'oligonucleotides lies a un agent intercalant, notamment a titre de medicament
US5252760A (en) * 1985-03-28 1993-10-12 Chiron Corporation Method of using colored phosphorylating reagents
WO1988003149A1 (en) * 1986-10-30 1988-05-05 Daicel Chemical Industries, Ltd. Process for synthesizing oligonucleotides and compounds for forming high-molecular protective group
DE3785343T2 (de) * 1986-12-02 1993-07-22 Centre Nat Rech Scient Alpha-oligonukleotide.
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
AU5418290A (en) * 1989-03-31 1990-11-05 University Patents Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
EP0558749A1 (de) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense-nukleinsäurederivate
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5220003A (en) * 1991-03-29 1993-06-15 The Regents Of The University Of California Process for the synthesis of 2',3'-dideoxynucleosides
JP3061659B2 (ja) * 1991-08-01 2000-07-10 ヤマサ醤油株式会社 ２−｛２−（モノメトキシトリチルオキシ）エチルチオ｝エチル基および該基の使用法
NZ245720A (en) * 1992-01-22 1995-12-21 Hoechst Ag Oligonucleotide analogues; use as gene expression inhibitor or dna probe
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
JPH09208729A (ja) * 1996-02-02 1997-08-12 Sekisui Chem Co Ltd 帯電防止プラスチックプレートもしくはシートの製造方法

Also Published As

Publication number Publication date
NO309427B1 (no) 2001-01-29
NZ280616A (en) 1997-04-24
KR100318796B1 (ko) 2002-06-20
FI111265B (fi) 2003-06-30
DE69401136T2 (de) 1997-07-10
IL108467A (en) 1999-09-22
CN1039014C (zh) 1998-07-08
HK1000191A1 (en) 1998-01-27
CZ19094A3 (en) 1994-12-15
IL108467A0 (en) 1994-04-12
RU2111971C1 (ru) 1998-05-27
NO940310L (no) 1994-08-01
EP0611075B1 (de) 1996-12-18
FI940425A (fi) 1994-11-04
HK1016151A1 (en) 1999-10-29
CN1193013A (zh) 1998-09-16
AU670154B2 (en) 1996-07-04
AU5473194A (en) 1994-08-04
US5674856A (en) 1997-10-07
CZ287050B6 (en) 2000-08-16
CN1065238C (zh) 2001-05-02
EP0611075A1 (de) 1994-08-17
KR940018394A (ko) 1994-08-16
US5807837A (en) 1998-09-15
HU222834B1 (hu) 2003-11-28
CN1098107A (zh) 1995-02-01
ES2098866T3 (es) 1997-05-01
FI940425A0 (fi) 1994-01-28
DK0611075T3 (da) 1997-07-07
HUT66266A (en) 1994-10-28
NO940310D0 (no) 1994-01-28
GR3022821T3 (en) 1997-06-30
HU9400246D0 (en) 1994-05-30
DE69401136D1 (de) 1997-01-30
NZ250795A (en) 1997-04-24
CA2114355A1 (en) 1994-07-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee