ATE146179T1 - 27 hydroxyrapamycin und derivate davon - Google Patents

27 hydroxyrapamycin und derivate davon

Info

Publication number
ATE146179T1
ATE146179T1 AT93919994T AT93919994T ATE146179T1 AT E146179 T1 ATE146179 T1 AT E146179T1 AT 93919994 T AT93919994 T AT 93919994T AT 93919994 T AT93919994 T AT 93919994T AT E146179 T1 ATE146179 T1 AT E146179T1
Authority
AT
Austria
Prior art keywords
hydroxyrapamycin
derivatives
formula
compound
deoxo
Prior art date
Application number
AT93919994T
Other languages
German (de)
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE146179T1 publication Critical patent/ATE146179T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93919994T 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon ATE146179T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE146179T1 true ATE146179T1 (de) 1996-12-15

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919994T ATE146179T1 (de) 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon

Country Status (12)

Country Link
EP (1) EP0655065B1 (en:Method)
JP (1) JPH08501084A (en:Method)
AT (1) ATE146179T1 (en:Method)
AU (1) AU5007193A (en:Method)
CA (1) CA2142288A1 (en:Method)
DE (1) DE69306585T2 (en:Method)
DK (1) DK0655065T3 (en:Method)
ES (1) ES2096941T3 (en:Method)
GR (1) GR3022730T3 (en:Method)
HU (1) HU221499B (en:Method)
MX (1) MX9304868A (en:Method)
WO (1) WO1994004540A1 (en:Method)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014023A1 (en) * 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
ES2187660T3 (es) 1995-06-09 2003-06-16 Novartis Ag Derivados de rapamicina.
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP1212331B1 (en) 1999-08-24 2004-04-21 Ariad Gene Therapeutics, Inc. 28-epirapalogs
JP4547911B2 (ja) * 2002-02-01 2010-09-22 アリアド・ファーマシューティカルズ・インコーポレイテッド リン含有化合物およびその用途
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
EP2094241A4 (en) 2006-11-14 2013-04-17 Ariad Pharma Inc ORAL FORMULATIONS
US8921642B2 (en) 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
US9593356B2 (en) 2013-06-11 2017-03-14 Takara Bio Usa, Inc. Protein enriched microvesicles and methods of making and using the same
MX2020011564A (es) 2018-05-01 2021-01-29 Revolution Medicines Inc Analogos de rapamicina unidos a c26 como inhibidores de mtor.
PE20252397A1 (es) 2018-05-01 2025-10-10 Revolution Medicines Inc Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor
EP4320101A2 (en) * 2021-04-09 2024-02-14 Revolution Medicines, Inc. Synthesis of rapamycin analog compounds
EP4531859A1 (en) 2022-05-25 2025-04-09 Revolution Medicines, Inc. Methods of treating cancer with an mtor inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
AU5007193A (en) 1994-03-15
HUT71614A (en) 1996-01-29
CA2142288A1 (en) 1994-03-03
DE69306585D1 (de) 1997-01-23
ES2096941T3 (es) 1997-03-16
JPH08501084A (ja) 1996-02-06
EP0655065B1 (en) 1996-12-11
EP0655065A1 (en) 1995-05-31
MX9304868A (es) 1994-05-31
HU9500432D0 (en) 1995-04-28
GR3022730T3 (en) 1997-06-30
DK0655065T3 (en:Method) 1997-02-24
DE69306585T2 (de) 1997-04-17
WO1994004540A1 (en) 1994-03-03
HU221499B (en) 2002-10-28

Similar Documents

Publication Publication Date Title
ATE146179T1 (de) 27 hydroxyrapamycin und derivate davon
ES2085726T3 (es) Derivado prolinico de rapamicina, su produccion y aplicacion.
ATE119774T1 (de) Imidazopyridinderivate und ihre verwendung.
ATE168992T1 (de) 7-substituierte-9-substituierte glycylamido-6- demethyl-6-deoxytetracycline
NO932873L (no) 9-(substituerte glycyl)amido)-6- dementyl-6-deoksotetrasykliner
DE69325130D1 (de) N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren
BG92804A (bg) 4-бензоилизоксазолови производни
DE69428142D1 (de) Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
NO904187D0 (no) Benzanilider.
DE69423339D1 (de) Epoxycyclohexendionderivat
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
DK377687A (da) Triazol-fungicidpraeparater
FI901277A0 (fi) 2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
DE69220222D1 (de) Neue D-Homo-17-oxa und D-Homo-17-aza-androstanderivate
DE69601451D1 (de) UCK14-Verbindungen
ATE255121T1 (de) Antitumor-indolopyrolocarbazolderivat
ES2149180T3 (es) Derivado de pirazolotiazolopirimidina.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee