ATE141921T1 - Methode zur herstellung von alpha, beta ungesättigten ketolactonen - Google Patents
Methode zur herstellung von alpha, beta ungesättigten ketolactonenInfo
- Publication number
- ATE141921T1 ATE141921T1 AT92302992T AT92302992T ATE141921T1 AT E141921 T1 ATE141921 T1 AT E141921T1 AT 92302992 T AT92302992 T AT 92302992T AT 92302992 T AT92302992 T AT 92302992T AT E141921 T1 ATE141921 T1 AT E141921T1
- Authority
- AT
- Austria
- Prior art keywords
- beta unsaturated
- producing alpha
- ketolactones
- unsaturated ketolactones
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- -1 bicyclolactone aldehyde Chemical class 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003752 zinc compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7148391 | 1991-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE141921T1 true ATE141921T1 (de) | 1996-09-15 |
Family
ID=13461939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92302992T ATE141921T1 (de) | 1991-04-04 | 1992-04-03 | Methode zur herstellung von alpha, beta ungesättigten ketolactonen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5229529A (show.php) |
| EP (1) | EP0507625B1 (show.php) |
| JP (1) | JPH089608B2 (show.php) |
| KR (1) | KR970003125B1 (show.php) |
| AT (1) | ATE141921T1 (show.php) |
| CA (1) | CA2064481C (show.php) |
| DE (1) | DE69213067T2 (show.php) |
| DK (1) | DK0507625T3 (show.php) |
| ES (1) | ES2093776T3 (show.php) |
| GR (1) | GR3020903T3 (show.php) |
| TW (1) | TW197439B (show.php) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE189216T1 (de) * | 1992-09-30 | 2000-02-15 | R Tech Ueno Ltd | Verfahren zur herstellung von alpha, beta- ungesättigten ketonen |
| CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| WO2002085337A1 (en) * | 2001-04-20 | 2002-10-31 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
| JP4358940B2 (ja) * | 1999-08-26 | 2009-11-04 | 丸善石油化学株式会社 | シクロヘキサンラクトン構造を有する重合性化合物及び重合体 |
| CA2307393A1 (en) | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
| US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
| EP2014307A3 (en) | 2001-03-13 | 2010-12-08 | Angiotech International Ag | Micellar drug delivery vehicles and uses thereof |
| US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
| DE10220729A1 (de) * | 2002-05-08 | 2003-11-20 | Martin Foerster | Verfahren zum Bestimmen einer von Tieren gesoffenen Menge an flüssigen Nahrungsmitteln |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| WO2004060346A2 (en) | 2002-12-30 | 2004-07-22 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| JP2007525188A (ja) | 2003-05-16 | 2007-09-06 | インターミューン インコーポレイテッド | 合成ケモカイン受容体リガンドおよびその使用方法 |
| WO2005040758A2 (en) * | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| US7846940B2 (en) * | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
| US7989490B2 (en) | 2004-06-02 | 2011-08-02 | Cordis Corporation | Injectable formulations of taxanes for cad treatment |
| US7597884B2 (en) * | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| MX2007001589A (es) * | 2004-08-09 | 2007-08-02 | Alios Biopharma Inc | Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas. |
| WO2006089209A2 (en) * | 2005-02-17 | 2006-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby |
| US20070073385A1 (en) * | 2005-09-20 | 2007-03-29 | Cook Incorporated | Eluting, implantable medical device |
| CN101379051B (zh) * | 2006-02-07 | 2014-05-28 | 株式会社·R-技术上野 | 用于制备前列腺素衍生物的方法 |
| ES2609388T3 (es) | 2006-03-22 | 2017-04-20 | Syncore Biotechnology Co., Ltd | Tratamiento del cáncer de mama triple negativo a receptores |
| ATE519511T1 (de) | 2006-06-30 | 2011-08-15 | Cook Inc | Verfahren zur herstellung und modifizierung von taxan-beschichtungen für implantierbare medizinische vorrichtungen |
| US20080241215A1 (en) * | 2007-03-28 | 2008-10-02 | Robert Falotico | Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke |
| US8409601B2 (en) | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
| US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
| US8273404B2 (en) * | 2008-05-19 | 2012-09-25 | Cordis Corporation | Extraction of solvents from drug containing polymer reservoirs |
| ES2530462T3 (es) | 2008-05-22 | 2015-03-03 | Galera Therapeutics Llc | Combinación terapia antitumoral |
| WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
| US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
| US8513441B2 (en) * | 2008-08-29 | 2013-08-20 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| EP2349279A4 (en) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF |
| EP2429982A4 (en) | 2009-01-22 | 2012-09-12 | Apotex Pharmachem Inc | METHOD FOR THE PRODUCTION OF LUBIPROSTON AND INTERMEDIATE PRODUCTS THEREOF |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| US20120303115A1 (en) | 2011-05-25 | 2012-11-29 | Dadino Ronald C | Expandable devices coated with a rapamycin composition |
| US20120302954A1 (en) | 2011-05-25 | 2012-11-29 | Zhao Jonathon Z | Expandable devices coated with a paclitaxel composition |
| US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| JP6578206B2 (ja) | 2012-07-19 | 2019-09-18 | レッドウッド バイオサイエンス, インコーポレイテッド | Cd22に特異的な抗体およびその使用方法 |
| WO2014074218A1 (en) | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| KR102332790B1 (ko) | 2013-02-15 | 2021-12-01 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| KR102320019B1 (ko) | 2013-11-27 | 2021-11-01 | 레드우드 바이오사이언스 인코포레이티드 | 히드라지닐-피롤로 화합물 및 콘쥬게이트 제조 방법 |
| EP3107899B1 (en) | 2014-02-19 | 2020-08-12 | Aviv Therapeutics, Inc. | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer |
| WO2017053920A1 (en) | 2015-09-25 | 2017-03-30 | Zy Therapeutics Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
| US10654875B2 (en) | 2015-11-12 | 2020-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
| TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
| US11208632B2 (en) | 2016-04-26 | 2021-12-28 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| BR112018074823B1 (pt) | 2016-06-01 | 2024-02-27 | Servier IP UK Limited | Composições liofilizadas, método de produção de uma composição, uso das composições e kit |
| TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
| EP3571229A1 (en) | 2017-01-18 | 2019-11-27 | F1 Oncology, Inc. | Chimeric antigen receptors against axl or ror2 and methods of use thereof |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| CN111065623B9 (zh) | 2017-05-24 | 2024-10-25 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| CA3090129A1 (en) | 2018-01-31 | 2019-08-08 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
| CA3096202A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| AU2019249221A1 (en) | 2018-04-06 | 2020-10-22 | The Regents Of The University Of California | Methods of treating glioblastomas |
| KR20210009315A (ko) | 2018-04-11 | 2021-01-26 | 오하이오 스테이트 이노베이션 파운데이션 | 안약 전달용 서방형 마이크로 입자를 이용한 방법 및 조성물 |
| WO2020018700A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
| TW202038994A (zh) | 2019-01-14 | 2020-11-01 | 美商醫格耐免疫治療公司 | 重組痘瘡病毒及其使用方法 |
| WO2020165730A1 (en) | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| MX2021012003A (es) | 2019-04-02 | 2021-11-04 | Kenjockety Biotechnology Inc | Anticuerpos multiespecificos contra antigeno de cancer de la bomba de eflujo y composiciones, reactivos, kits y metodos relacionados con los mismos. |
| AU2020402303A1 (en) | 2019-12-12 | 2022-06-09 | Ignite Immunotherapy, Inc. | Variant oncolytic vaccinia virus and methods of use thereof |
| KR20220133884A (ko) | 2020-01-29 | 2022-10-05 | 켄조케티 바이오테크놀러지 인코포레이티드 | 항-mdr1 항체 및 이의 용도 |
| CN116529267A (zh) | 2020-06-04 | 2023-08-01 | 肯乔克蒂生物技术股份有限公司 | Abcg2外排泵-癌症抗原多特异性抗体及其相关组合物、试剂、试剂盒和方法 |
| JP7767322B2 (ja) | 2020-06-04 | 2025-11-11 | ウィリアム ロバート アラスーン リビング トラスト デイテッド オーガスト 29, 2016 | 抗abcg2抗体及びそれらの使用 |
| KR20230023032A (ko) | 2020-07-14 | 2023-02-16 | 화이자 인코포레이티드 | 재조합 백시니아 바이러스 |
| KR20230061429A (ko) | 2020-09-02 | 2023-05-08 | 켄조케티 바이오테크놀러지 인코포레이티드 | 항-abcc1 항체 및 이의 용도 |
| AU2021380659A1 (en) | 2020-11-13 | 2023-06-01 | Kenjockety Biotechnology, Inc. | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
| US12187810B2 (en) | 2020-11-20 | 2025-01-07 | R.P. Scherer Technologies, Llc | Glycoside dual-cleavage linkers for antibody-drug conjugates |
| KR20240116829A (ko) | 2021-12-13 | 2024-07-30 | 윌리엄 로버트 아라툰 리빙 트러스트 데이티드 어거스트 29, 2016 | 항-abcb1 항체 |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032576A (show.php) * | 1976-01-08 | 1977-06-28 | ||
| DE2655004C3 (de) * | 1976-12-02 | 1980-06-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von bicyclischen Laktonen |
| DE3574470D1 (en) * | 1985-09-18 | 1990-01-04 | Upjohn Co | Stereoselective reduktion. |
| JPS62153259A (ja) * | 1985-12-26 | 1987-07-08 | Sagami Chem Res Center | (2−クロロ−3−オキソ−1−アルケニル)−ビシクロ〔3.3.0〕オクテン誘導体及びその製法 |
| DE3620442A1 (de) * | 1986-06-18 | 1987-12-23 | Merck Patent Gmbh | Ketolactone |
| JP2588269B2 (ja) * | 1987-09-04 | 1997-03-05 | ジ・アップジョン・カンパニー | プロスタグランジン中間体類の製法 |
-
1992
- 1992-03-28 TW TW081102387A patent/TW197439B/zh active
- 1992-03-30 JP JP4073782A patent/JPH089608B2/ja not_active Expired - Lifetime
- 1992-03-31 CA CA002064481A patent/CA2064481C/en not_active Expired - Fee Related
- 1992-04-01 US US07/861,518 patent/US5229529A/en not_active Expired - Lifetime
- 1992-04-03 EP EP92302992A patent/EP0507625B1/en not_active Expired - Lifetime
- 1992-04-03 ES ES92302992T patent/ES2093776T3/es not_active Expired - Lifetime
- 1992-04-03 DE DE69213067T patent/DE69213067T2/de not_active Expired - Fee Related
- 1992-04-03 DK DK92302992.0T patent/DK0507625T3/da active
- 1992-04-03 AT AT92302992T patent/ATE141921T1/de not_active IP Right Cessation
- 1992-04-04 KR KR1019920005662A patent/KR970003125B1/ko not_active Expired - Fee Related
-
1996
- 1996-08-29 GR GR960402124T patent/GR3020903T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69213067T2 (de) | 1997-01-16 |
| KR920019771A (ko) | 1992-11-20 |
| DE69213067D1 (de) | 1996-10-02 |
| GR3020903T3 (en) | 1996-11-30 |
| CA2064481A1 (en) | 1992-10-05 |
| ES2093776T3 (es) | 1997-01-01 |
| KR970003125B1 (ko) | 1997-03-14 |
| CA2064481C (en) | 1996-12-24 |
| DK0507625T3 (da) | 1996-09-16 |
| JPH0592965A (ja) | 1993-04-16 |
| EP0507625A1 (en) | 1992-10-07 |
| US5229529A (en) | 1993-07-20 |
| EP0507625B1 (en) | 1996-08-28 |
| JPH089608B2 (ja) | 1996-01-31 |
| TW197439B (show.php) | 1993-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE141921T1 (de) | Methode zur herstellung von alpha, beta ungesättigten ketolactonen | |
| NO944644D0 (no) | Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter | |
| ATE74592T1 (de) | Verfahren zur herstellung fungizid aktiver 4phenyl-pyrrol-derivate. | |
| ATE176236T1 (de) | Verfahren zur herstellung von diorganodialkoxysilanen | |
| EP0165458A3 (en) | (+)-ambrox, process for production thereof and use thereof | |
| IL80391A (en) | Process for the preparation of decabromodiphenyl ether with improved thermal stability | |
| ES2060570T1 (es) | Procedimiento para la preparacion de acidos alfa-arilpropionicos. | |
| ES2045215T3 (es) | (+)-o (+)-1-(2-n-aminoetil sustituido) -1-metil-7-metoxi-1,2,3,4-tetrahidronaftaleno, y procedimiento para su produccion. | |
| ES2057289T3 (es) | Procedimiento para la obtencion de octadienoles. | |
| ATE49185T1 (de) | Verfahren zur herstellung von halogen-magnesium- alanat und dessen verwendung. | |
| ATE276225T1 (de) | Verfahren zur herstellung von 2,7-dimethyl-2,4,6- octatrienal-monoacetalen | |
| DE69914493D1 (de) | Verfahren zur herstellung von 2-hydroxy-6-trifluormethylpyridin | |
| ES2145060T3 (es) | Procedimiento para producir una cetona alfa, beta insaturada. | |
| ATE57520T1 (de) | Verfahren zur herstellung von bromierten bisphenolen. | |
| ATE106858T1 (de) | Verfahren zur herstellung von halogenacetalen aus enaminen. | |
| DE59209468D1 (de) | Verfahren zur herstellung von 2,5-dihydroxyphenylessigsäure | |
| ATE168110T1 (de) | Verfahren und zwischenprodukte zur herstellung von 5-oxaspiro (2.4> heptan-6-on | |
| ATE46315T1 (de) | Verfahren zur herstellung optisch aktiver chinonderivate. | |
| ATE41141T1 (de) | Verfahren zur herstellung von trichlorphenol. | |
| ATE59375T1 (de) | Verfahren zur herstellung von polyenaldehyden. | |
| ES535991A0 (es) | Un procedimiento para preparar un 10-ftalil-1, 5-diprotegido-1, 5, 10-triazadecano | |
| ATE10936T1 (de) | Verfahren zur herstellung von 2-alkoxy-4aminopyrimidinen. | |
| ES2070517T3 (es) | Productos intermedios en la preparacion del acido 4,5-difluoroantranilico. | |
| GB2097792B (en) | 1,3-dihydro-2h-imidazol-2-ones | |
| GR3017087T3 (en) | Process for the purification of pseudo-ionone. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |