ATE137214T1 - Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierung - Google Patents
Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierungInfo
- Publication number
- ATE137214T1 ATE137214T1 AT91122418T AT91122418T ATE137214T1 AT E137214 T1 ATE137214 T1 AT E137214T1 AT 91122418 T AT91122418 T AT 91122418T AT 91122418 T AT91122418 T AT 91122418T AT E137214 T1 ATE137214 T1 AT E137214T1
- Authority
- AT
- Austria
- Prior art keywords
- chelates
- diethylenetriamin
- polysubstituted
- chelate
- metal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
- C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/903,723 US4831175A (en) | 1986-09-05 | 1986-09-05 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
CA000594072A CA1338721C (en) | 1986-09-05 | 1989-03-17 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE137214T1 true ATE137214T1 (de) | 1996-05-15 |
Family
ID=25672531
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91122418T ATE137214T1 (de) | 1986-09-05 | 1987-09-04 | Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierung |
AT92114713T ATE144496T1 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung hauptkettenpolysubstituierter chelate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92114713T ATE144496T1 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung hauptkettenpolysubstituierter chelate |
Country Status (9)
Country | Link |
---|---|
US (1) | US4831175A (de) |
EP (1) | EP0328529B1 (de) |
JP (2) | JP2555391B2 (de) |
KR (1) | KR920003590B1 (de) |
AT (2) | ATE137214T1 (de) |
AU (1) | AU611105B2 (de) |
CA (1) | CA1338721C (de) |
DE (3) | DE3751936T2 (de) |
WO (1) | WO1988001618A1 (de) |
Families Citing this family (110)
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US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
US5696239A (en) * | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
NZ231180A (en) * | 1988-10-31 | 1994-11-25 | Dow Chemical Co | Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof |
US5342604A (en) * | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
US5403862A (en) * | 1992-01-17 | 1995-04-04 | University Of Utah Research Foundation | Method for oral decorporation of metals |
US5494935A (en) * | 1992-01-17 | 1996-02-27 | University Of Utah Research Foundation | Methods for oral decorporation of metals |
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US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
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Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
FI82379C (fi) * | 1981-10-27 | 1991-03-11 | Univ California | Radioaktivt maerkta monoklonala antikroppar samt en komposition innehaollande dessa och anvaendbar som diagnostiskt radiofarmaseutiskt medel. |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
-
1986
- 1986-09-05 US US06/903,723 patent/US4831175A/en not_active Expired - Lifetime
-
1987
- 1987-09-04 KR KR1019880700490A patent/KR920003590B1/ko not_active IP Right Cessation
- 1987-09-04 AT AT91122418T patent/ATE137214T1/de not_active IP Right Cessation
- 1987-09-04 AT AT92114713T patent/ATE144496T1/de active
- 1987-09-04 DE DE3751936T patent/DE3751936T2/de not_active Expired - Lifetime
- 1987-09-04 WO PCT/US1987/002207 patent/WO1988001618A1/en active IP Right Grant
- 1987-09-04 DE DE3788961T patent/DE3788961T2/de not_active Expired - Lifetime
- 1987-09-04 DE DE3751788T patent/DE3751788T2/de not_active Expired - Lifetime
- 1987-09-04 EP EP87906504A patent/EP0328529B1/de not_active Expired - Lifetime
- 1987-09-04 AU AU80743/87A patent/AU611105B2/en not_active Ceased
- 1987-09-04 JP JP62505982A patent/JP2555391B2/ja not_active Expired - Lifetime
-
1989
- 1989-03-17 CA CA000594072A patent/CA1338721C/en not_active Expired - Fee Related
-
1996
- 1996-03-12 JP JP8055048A patent/JP2659351B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU611105B2 (en) | 1991-06-06 |
DE3751936T2 (de) | 1997-04-03 |
CA1338721C (en) | 1996-11-12 |
US4831175A (en) | 1989-05-16 |
JP2659351B2 (ja) | 1997-09-30 |
DE3751788T2 (de) | 1996-11-28 |
DE3751788D1 (de) | 1996-05-30 |
DE3788961D1 (de) | 1994-03-10 |
DE3788961T2 (de) | 1994-07-14 |
ATE144496T1 (de) | 1996-11-15 |
JP2555391B2 (ja) | 1996-11-20 |
JPH08231474A (ja) | 1996-09-10 |
EP0328529A1 (de) | 1989-08-23 |
DE3751936D1 (de) | 1996-11-28 |
AU8074387A (en) | 1988-03-24 |
EP0328529B1 (de) | 1994-01-26 |
JPH02501385A (ja) | 1990-05-17 |
KR920003590B1 (ko) | 1992-05-04 |
KR880701708A (ko) | 1988-11-04 |
WO1988001618A1 (en) | 1988-03-10 |
EP0328529A4 (en) | 1991-03-20 |
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