ATE137214T1 - Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierung - Google Patents
Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierungInfo
- Publication number
- ATE137214T1 ATE137214T1 AT91122418T AT91122418T ATE137214T1 AT E137214 T1 ATE137214 T1 AT E137214T1 AT 91122418 T AT91122418 T AT 91122418T AT 91122418 T AT91122418 T AT 91122418T AT E137214 T1 ATE137214 T1 AT E137214T1
- Authority
- AT
- Austria
- Prior art keywords
- chelates
- diethylenetriamin
- polysubstituted
- chelate
- metal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
- C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/903,723 US4831175A (en) | 1986-09-05 | 1986-09-05 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
CA000594072A CA1338721C (en) | 1986-09-05 | 1989-03-17 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE137214T1 true ATE137214T1 (de) | 1996-05-15 |
Family
ID=25672531
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91122418T ATE137214T1 (de) | 1986-09-05 | 1987-09-04 | Polysubstituierte diethylentriamin chelate zur bildung einer metall-chelat-protein konjugierung |
AT92114713T ATE144496T1 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung hauptkettenpolysubstituierter chelate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92114713T ATE144496T1 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung hauptkettenpolysubstituierter chelate |
Country Status (9)
Country | Link |
---|---|
US (1) | US4831175A (de) |
EP (1) | EP0328529B1 (de) |
JP (2) | JP2555391B2 (de) |
KR (1) | KR920003590B1 (de) |
AT (2) | ATE137214T1 (de) |
AU (1) | AU611105B2 (de) |
CA (1) | CA1338721C (de) |
DE (3) | DE3751788T2 (de) |
WO (1) | WO1988001618A1 (de) |
Families Citing this family (110)
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US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
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US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
NZ231180A (en) * | 1988-10-31 | 1994-11-25 | Dow Chemical Co | Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof |
US5342604A (en) * | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
US5696239A (en) * | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
US5494935A (en) * | 1992-01-17 | 1996-02-27 | University Of Utah Research Foundation | Methods for oral decorporation of metals |
US5403862A (en) * | 1992-01-17 | 1995-04-04 | University Of Utah Research Foundation | Method for oral decorporation of metals |
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US7744877B2 (en) * | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
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WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF |
EP3758749A4 (de) | 2018-03-02 | 2022-07-06 | The University of Chicago | Verfahren und zusammensetzung zur neutralisierung von influenza |
CN118108836A (zh) | 2018-12-19 | 2024-05-31 | 胡默波斯生物医学公司 | 中和乙型肝炎病毒的抗体和其用途 |
EP4021578A1 (de) | 2019-08-29 | 2022-07-06 | VIR Biotechnology, Inc. | Antikörperzusammensetzungen und verfahren zur behandlung einer hepatitis-b-virusinfektion |
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AU2021296848A1 (en) | 2020-06-24 | 2023-02-09 | Humabs Biomed Sa | Engineered hepatitis B virus neutralizing antibodies and uses thereof |
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TW202245838A (zh) | 2021-01-26 | 2022-12-01 | 美商維爾生物科技股份有限公司 | 用於治療b型肝炎病毒感染的組成物及方法 |
US20240150449A1 (en) | 2021-03-10 | 2024-05-09 | Mabylon Ag | Antibodies against tdp-43 and methods of using the same |
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WO2023057946A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Serum half-life extended pd-l1 binding polypeptides |
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WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
FR2515046B1 (fr) * | 1981-10-27 | 1985-11-29 | Hybritech Inc | Anticorps monoclonaux marques par un radionucleide et leur application a la visualisation d'une tumeur |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
-
1986
- 1986-09-05 US US06/903,723 patent/US4831175A/en not_active Expired - Lifetime
-
1987
- 1987-09-04 DE DE3751788T patent/DE3751788T2/de not_active Expired - Lifetime
- 1987-09-04 EP EP87906504A patent/EP0328529B1/de not_active Expired - Lifetime
- 1987-09-04 KR KR1019880700490A patent/KR920003590B1/ko not_active IP Right Cessation
- 1987-09-04 AT AT91122418T patent/ATE137214T1/de not_active IP Right Cessation
- 1987-09-04 AU AU80743/87A patent/AU611105B2/en not_active Ceased
- 1987-09-04 JP JP62505982A patent/JP2555391B2/ja not_active Expired - Lifetime
- 1987-09-04 DE DE3751936T patent/DE3751936T2/de not_active Expired - Lifetime
- 1987-09-04 WO PCT/US1987/002207 patent/WO1988001618A1/en active IP Right Grant
- 1987-09-04 AT AT92114713T patent/ATE144496T1/de active
- 1987-09-04 DE DE3788961T patent/DE3788961T2/de not_active Expired - Lifetime
-
1989
- 1989-03-17 CA CA000594072A patent/CA1338721C/en not_active Expired - Fee Related
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1996
- 1996-03-12 JP JP8055048A patent/JP2659351B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3751788D1 (de) | 1996-05-30 |
EP0328529B1 (de) | 1994-01-26 |
DE3788961D1 (de) | 1994-03-10 |
EP0328529A4 (en) | 1991-03-20 |
JPH02501385A (ja) | 1990-05-17 |
AU611105B2 (en) | 1991-06-06 |
ATE144496T1 (de) | 1996-11-15 |
KR920003590B1 (ko) | 1992-05-04 |
JP2659351B2 (ja) | 1997-09-30 |
EP0328529A1 (de) | 1989-08-23 |
US4831175A (en) | 1989-05-16 |
KR880701708A (ko) | 1988-11-04 |
DE3788961T2 (de) | 1994-07-14 |
DE3751936D1 (de) | 1996-11-28 |
JPH08231474A (ja) | 1996-09-10 |
AU8074387A (en) | 1988-03-24 |
WO1988001618A1 (en) | 1988-03-10 |
DE3751788T2 (de) | 1996-11-28 |
JP2555391B2 (ja) | 1996-11-20 |
DE3751936T2 (de) | 1997-04-03 |
CA1338721C (en) | 1996-11-12 |
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