DE3751936D1 - Verfahren zur Herstellung hauptkettenpolysubstituierter Chelate - Google Patents
Verfahren zur Herstellung hauptkettenpolysubstituierter ChelateInfo
- Publication number
- DE3751936D1 DE3751936D1 DE3751936T DE3751936T DE3751936D1 DE 3751936 D1 DE3751936 D1 DE 3751936D1 DE 3751936 T DE3751936 T DE 3751936T DE 3751936 T DE3751936 T DE 3751936T DE 3751936 D1 DE3751936 D1 DE 3751936D1
- Authority
- DE
- Germany
- Prior art keywords
- chelates
- substituted
- production
- main chain
- chain poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
- C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/903,723 US4831175A (en) | 1986-09-05 | 1986-09-05 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
CA000594072A CA1338721C (en) | 1986-09-05 | 1989-03-17 | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3751936D1 true DE3751936D1 (de) | 1996-11-28 |
DE3751936T2 DE3751936T2 (de) | 1997-04-03 |
Family
ID=25672531
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751936T Expired - Lifetime DE3751936T2 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur Herstellung hauptkettenpolysubstituierter Chelate |
DE3788961T Expired - Lifetime DE3788961T2 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung von polysubstituierten diethylentriaminpentaessigsäuren. |
DE3751788T Expired - Lifetime DE3751788T2 (de) | 1986-09-05 | 1987-09-04 | Polysubstituierte Diethylentriamin Chelate zur Bildung einer Metall-Chelat-Protein Konjugierung |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3788961T Expired - Lifetime DE3788961T2 (de) | 1986-09-05 | 1987-09-04 | Verfahren zur herstellung von polysubstituierten diethylentriaminpentaessigsäuren. |
DE3751788T Expired - Lifetime DE3751788T2 (de) | 1986-09-05 | 1987-09-04 | Polysubstituierte Diethylentriamin Chelate zur Bildung einer Metall-Chelat-Protein Konjugierung |
Country Status (9)
Country | Link |
---|---|
US (1) | US4831175A (de) |
EP (1) | EP0328529B1 (de) |
JP (2) | JP2555391B2 (de) |
KR (1) | KR920003590B1 (de) |
AT (2) | ATE137214T1 (de) |
AU (1) | AU611105B2 (de) |
CA (1) | CA1338721C (de) |
DE (3) | DE3751936T2 (de) |
WO (1) | WO1988001618A1 (de) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US5227474A (en) * | 1987-02-13 | 1993-07-13 | Abbott Laboratories | Bifunctional chelating agents |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
US5696239A (en) * | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
NZ231180A (en) * | 1988-10-31 | 1994-11-25 | Dow Chemical Co | Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof |
US5342604A (en) * | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
US5403862A (en) * | 1992-01-17 | 1995-04-04 | University Of Utah Research Foundation | Method for oral decorporation of metals |
US5494935A (en) * | 1992-01-17 | 1996-02-27 | University Of Utah Research Foundation | Methods for oral decorporation of metals |
EP0752248B1 (de) * | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
US7744877B2 (en) * | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
CN1689646A (zh) | 1998-08-11 | 2005-11-02 | 拜奥根Idec公司 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
DK2055313T3 (en) * | 1998-11-09 | 2015-07-27 | Biogen Inc | Treatment of Hematologic Malignancies Related to Circulating Tumor Cells Using Chimeric Anti-CD20 Antibody |
CA2350064C (en) * | 1998-11-09 | 2012-05-08 | Idec Pharmaceuticals Corporation | Chimeric anti-cd20 antibody treatment of patients receiving bmt or pbsc transplants |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
US6207858B1 (en) * | 1999-03-03 | 2001-03-27 | Idec Pharmaceuticals Corporation | Regioselective synthesis of DTPA derivatives |
EP1918305A1 (de) | 1999-08-11 | 2008-05-07 | Biogen Idec Inc. | Neue klinische Parameter zur Bestimmung der hämatologischen Toxizität vor einer Strahlenimmuntherapie |
US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
EP2264070A1 (de) | 1999-08-11 | 2010-12-22 | Biogen-Idec Inc. | Behandlung eines intermediären und hochgradigen Non-Hodgkins-Lymphoms mit Anti-CD20-Antikörper |
US6682902B2 (en) * | 1999-12-16 | 2004-01-27 | Schering Aktiengesellschaft | DNA encoding a novel RG1 polypeptide |
US20020009444A1 (en) * | 2000-04-25 | 2002-01-24 | Idec Pharmaceuticals Corporation | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
EP1717251B1 (de) | 2000-10-02 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Humane Antikörper gegen CD40 zur Therapie von B-Zell Tumoren |
WO2002060484A1 (en) | 2001-01-31 | 2002-08-08 | Idec Pharmaceuticals Corporation | Use of cd23 antagonists for the treatment of neoplastic disorders |
US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
JP4463475B2 (ja) | 2001-01-31 | 2010-05-19 | バイオジェン アイデック インコーポレイテッド | 腫瘍疾患の治療における免疫調節性抗体の使用 |
AU2002307037B2 (en) * | 2001-04-02 | 2008-08-07 | Biogen Idec Inc. | Recombinant antibodies coexpressed with GnTIII |
JP2004534808A (ja) * | 2001-06-22 | 2004-11-18 | シエーリング アクチエンゲゼルシャフト | (エチレン)−(プロピレン)−トリアミン五酢酸誘導体類、それらの製造方法、及び医薬剤の製造のためへのそれらの使用 |
US20030194371A1 (en) * | 2001-07-10 | 2003-10-16 | Schering Ag | (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents |
TWI284539B (en) | 2001-07-30 | 2007-08-01 | Epix Pharm Inc | A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide |
WO2003048306A2 (en) | 2001-11-16 | 2003-06-12 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
US20080063639A1 (en) * | 2002-01-18 | 2008-03-13 | Pierre Fabre Medicament | Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies |
AU2003228269A1 (en) * | 2002-03-01 | 2003-09-16 | Mds Proteomics Inc. | Phosphorylated proteins and uses related thereto |
CA2514062A1 (en) * | 2003-01-27 | 2004-08-12 | Biogen Idec Ma Inc. | Compositions and methods for treating cancer using igsf9 and liv-1 |
DE10305463A1 (de) * | 2003-02-04 | 2004-08-12 | Schering Ag | Enantiomerenreines (4S,8S)- und (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triza-3N,6N,9N-tricarboxymethyl-1,11-undecandisäure und deren Abkömmlinge, Verfahren zu deren Herstellung und Verwendung zur Herstellung pharmazeutischer Mittel |
DE10305462A1 (de) * | 2003-02-04 | 2004-08-12 | Schering Ag | Konjugate enantiomerenreiner (4S,8S)- und (4R,8R)-4-p-Benzyl-8-methyl-3,6,9-triaza-3N, 6N, 9N-tricarboxymethyl-1,11-undecandisäure mit Biomolekülen, Verfahren zu deren Herstellung und Verwendung zur Herstellung |
EP1613750B1 (de) | 2003-03-19 | 2015-10-14 | Amgen Fremont Inc. | Antikörper gegen das t-zellen-immunglobulindomäne- und mucindomäne-1 (tim-1) antigen und verwendungen davon |
UY28424A1 (es) * | 2003-07-22 | 2005-02-28 | Schering Ag | Anticuerpos rgi y usos de los mismos. |
DE602004028272D1 (de) | 2003-11-04 | 2010-09-02 | Novartis Vaccines & Diagnostic | Verwendung von antagonisten-anti-cd40-monoklonalen antikörpern zur behandlung von multiplem myelom |
DE602004028270D1 (de) | 2003-11-04 | 2010-09-02 | Novartis Vaccines & Diagnostic | Verwendung von antagonisten-anti-cd40-antikörpern zur behandlung von chronisch lymphozytischer leukämie |
JP4810431B2 (ja) | 2003-11-04 | 2011-11-09 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | B細胞に関連する癌に対する治療方法 |
CA2544852A1 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Methods of therapy for solid tumors expressing the cd40 cell-surface antigen |
DK1682178T3 (da) | 2003-11-04 | 2010-10-04 | Novartis Vaccines & Diagnostic | Fremgangsmåder til terapi af cancere der udtrykker CD-40-antigenet |
SG148161A1 (en) * | 2003-11-05 | 2008-12-31 | Palingen Inc | Enhanced b cell cytotoxicity of cdim binding antibody |
EP1689448B1 (de) * | 2003-12-01 | 2015-07-29 | Immunomedics Inc. | Verfahren zur herstellung von dota-antikörper konjugaten |
FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
EP1814913B1 (de) | 2004-11-05 | 2015-08-19 | IGM Biosciences, Inc. | Antikörperinduzierte zellmembranverletzung |
WO2006056443A2 (en) * | 2004-11-24 | 2006-06-01 | Aplagen Gmbh | Method for solid-phase peptide synthesis and purification |
CA2589374C (en) | 2004-11-30 | 2016-05-03 | Curagen Corporation | Antibodies directed to gpnmb and uses thereof |
WO2006074397A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Cripto binding molecules |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
CA2629453C (en) | 2005-11-10 | 2018-03-06 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
FI20055653A (fi) * | 2005-12-08 | 2007-06-09 | Wallac Oy | Leimausreagenssi |
DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
US7727525B2 (en) * | 2006-05-11 | 2010-06-01 | City Of Hope | Engineered anti-CD20 antibody fragments for in vivo targeting and therapeutics |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
US20100092384A1 (en) * | 2007-03-19 | 2010-04-15 | The Junited States Of America As Represented By Secretary, Dept. Of Health And Human Service | Multifunctional nanoparticles and compositions and methods of use thereof |
EP2014681A1 (de) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Neue Antikörper zur Hemmung der C-Met-Dimerisation und Verwendungen davon |
WO2009012288A2 (en) * | 2007-07-17 | 2009-01-22 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging |
HUE025283T2 (en) | 2007-08-02 | 2016-03-29 | Gilead Biologics Inc | LOX and LOX2 inhibitors and their use |
US10189803B2 (en) | 2008-02-22 | 2019-01-29 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
US9446995B2 (en) | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
CA2730620A1 (en) | 2008-07-16 | 2010-01-21 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
MX338067B (es) | 2008-07-16 | 2016-04-01 | Inst Research In Biomedicine | Anticuerpos neutralizantes de citomegalovirus humano y uso de los mismos. |
US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
JP2011528902A (ja) * | 2008-07-25 | 2011-12-01 | インスティテュート・フォー・リサーチ・イン・バイオメディシン | 抗a型インフルエンザウイルス中和抗体およびその使用 |
EP2172485A1 (de) | 2008-10-01 | 2010-04-07 | Pierre Fabre Medicament | Neuartige Anti-CXCR4-Antikörper und ihre Verwendung bei der Krebsbehandlung |
AU2009305113B2 (en) | 2008-10-13 | 2015-07-16 | Institute For Research In Biomedicine | Dengue virus neutralizing antibodies and uses thereof |
AR074439A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
US8545839B2 (en) | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
CN102341411A (zh) | 2008-12-31 | 2012-02-01 | 比奥根艾迪克Ma公司 | 抗-淋巴细胞毒素抗体 |
EP2308897A1 (de) | 2009-10-09 | 2011-04-13 | Pierre Fabre Medicament | Chimäre Antikörper spezifisch für CD151 und deren Verwendung zur Behandlung von Krebs |
US20110212106A1 (en) | 2010-01-20 | 2011-09-01 | Institute For Research In Bioscience | Hiv-1 neutralizing antibodies and uses thereof |
EP2371863A1 (de) | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Menschlische Antikörper gegen CXCR4 zur Behandlung von Krebs |
EP2455403A1 (de) | 2010-11-23 | 2012-05-23 | Pierre Fabre Medicament | Homogene humanisierte Antikörper gegen JAM-A die Proliferation inhibieren |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
SI2734545T1 (sl) | 2011-07-18 | 2019-06-28 | Institute For Research In Biomedicine | Protitelesa, ki nevtralizirajo virus influence A in njihova uporaba |
MX363819B (es) | 2012-02-08 | 2019-04-03 | Igm Biosciences Inc | Uniones a cdim y sus usos. |
CA2865856C (en) | 2012-03-20 | 2023-03-14 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
WO2013180730A1 (en) * | 2012-06-01 | 2013-12-05 | Lawrence Lowell Jeffry | Large-scale high yield manufacturing process for high purity pentaalkyl esters of dtpa |
AU2014329609B2 (en) | 2013-10-02 | 2019-09-12 | Humabs Biomed Sa | Neutralizing anti-influenza A antibodies and uses thereof |
US10441669B2 (en) | 2013-10-04 | 2019-10-15 | Illinois Institute Of Technology | Multifunctional chelators, complexes, and compositions thereof, and methods of using same |
AU2015289805B2 (en) | 2014-07-15 | 2020-06-25 | Humabs Biomed Sa | Neutralizing anti-influenza B antibodies and uses thereof |
WO2016055950A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Combination of human cytomegalovirus neutralizing antibodies |
WO2016075546A2 (en) | 2014-11-14 | 2016-05-19 | Antonio Lanzavecchia | Antibodies that neutralize ebola virus and uses thereof |
CN114805558B (zh) | 2014-11-18 | 2023-12-29 | 胡默波斯生物医学公司 | 强力地中和狂犬病毒和其它狂犬病毒属病毒的抗体和其用途 |
US10357563B2 (en) | 2014-12-18 | 2019-07-23 | The University Of Chicago | Methods and composition for neutralization of influenza |
DK3303384T3 (da) | 2015-06-01 | 2021-10-18 | Medimmune Llc | Neutraliserende anti-influenza-bindingsmolekyler og anvendelser deraf |
EP3313871A1 (de) | 2015-06-26 | 2018-05-02 | Institute for Research in Biomedicine | Proteine mit mutiertem lair-1-fragment und verwendungen davon |
WO2017059878A1 (en) | 2015-10-07 | 2017-04-13 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis b virus and uses thereof |
NZ743713A (en) | 2015-12-15 | 2020-01-31 | Gilead Sciences Inc | Human immunodeficiency virus neutralizing antibodies |
SG11201805001UA (en) | 2016-01-13 | 2018-07-30 | Medimmune Llc | Method of treating influenza a |
WO2018010789A1 (en) | 2016-07-13 | 2018-01-18 | Humabs Biomed Sa | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
US11235076B2 (en) | 2016-08-29 | 2022-02-01 | Fred Hutchinson Cancer Research Center | Chelating platform for delivery of radionuclides |
US20200093909A1 (en) | 2017-04-19 | 2020-03-26 | Institute For Research In Biomedicine | Plasmodium sporozoite npdp peptides as vaccine and target novel malaria vaccines and antibodies binding to |
GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF |
WO2019169231A1 (en) | 2018-03-02 | 2019-09-06 | The University Of Chicago | Methods and composition for neutralization of influenza |
PT3898668T (pt) | 2018-12-19 | 2023-12-06 | Humabs Biomed Sa | Anticorpos que neutralizam o vírus da hepatite b e suas utilizações |
CA3152511A1 (en) | 2019-08-29 | 2021-03-04 | Vir Biotechnology, Inc. | Antibody compositions and methods for treating hepatitis b virus infection |
GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
BR112022026316A2 (pt) | 2020-06-24 | 2023-03-07 | Vir Biotechnology Inc | Anticorpos neutralizantes do vírus da hepatite b engenheirados e usos dos mesmos |
US20230390409A1 (en) | 2020-10-30 | 2023-12-07 | Avacta Life Sciences Limited | Fap-activated serum extended half-life therapeutic conjugates |
US20240092872A1 (en) | 2021-01-26 | 2024-03-21 | Vir Biotechnology, Inc. | Compositions and methods for treating hepatitis b virus infection |
WO2022189558A2 (en) | 2021-03-10 | 2022-09-15 | Mabylon Ag | Antibodies against tdp-43 and methods of using the same |
WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之pd-l1結合多肽 |
WO2023057567A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
FI82379C (fi) * | 1981-10-27 | 1991-03-11 | Univ California | Radioaktivt maerkta monoklonala antikroppar samt en komposition innehaollande dessa och anvaendbar som diagnostiskt radiofarmaseutiskt medel. |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
-
1986
- 1986-09-05 US US06/903,723 patent/US4831175A/en not_active Expired - Lifetime
-
1987
- 1987-09-04 KR KR1019880700490A patent/KR920003590B1/ko not_active IP Right Cessation
- 1987-09-04 AT AT91122418T patent/ATE137214T1/de not_active IP Right Cessation
- 1987-09-04 AT AT92114713T patent/ATE144496T1/de active
- 1987-09-04 DE DE3751936T patent/DE3751936T2/de not_active Expired - Lifetime
- 1987-09-04 WO PCT/US1987/002207 patent/WO1988001618A1/en active IP Right Grant
- 1987-09-04 DE DE3788961T patent/DE3788961T2/de not_active Expired - Lifetime
- 1987-09-04 DE DE3751788T patent/DE3751788T2/de not_active Expired - Lifetime
- 1987-09-04 EP EP87906504A patent/EP0328529B1/de not_active Expired - Lifetime
- 1987-09-04 AU AU80743/87A patent/AU611105B2/en not_active Ceased
- 1987-09-04 JP JP62505982A patent/JP2555391B2/ja not_active Expired - Lifetime
-
1989
- 1989-03-17 CA CA000594072A patent/CA1338721C/en not_active Expired - Fee Related
-
1996
- 1996-03-12 JP JP8055048A patent/JP2659351B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU611105B2 (en) | 1991-06-06 |
ATE137214T1 (de) | 1996-05-15 |
DE3751936T2 (de) | 1997-04-03 |
CA1338721C (en) | 1996-11-12 |
US4831175A (en) | 1989-05-16 |
JP2659351B2 (ja) | 1997-09-30 |
DE3751788T2 (de) | 1996-11-28 |
DE3751788D1 (de) | 1996-05-30 |
DE3788961D1 (de) | 1994-03-10 |
DE3788961T2 (de) | 1994-07-14 |
ATE144496T1 (de) | 1996-11-15 |
JP2555391B2 (ja) | 1996-11-20 |
JPH08231474A (ja) | 1996-09-10 |
EP0328529A1 (de) | 1989-08-23 |
AU8074387A (en) | 1988-03-24 |
EP0328529B1 (de) | 1994-01-26 |
JPH02501385A (ja) | 1990-05-17 |
KR920003590B1 (ko) | 1992-05-04 |
KR880701708A (ko) | 1988-11-04 |
WO1988001618A1 (en) | 1988-03-10 |
EP0328529A4 (en) | 1991-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3751936D1 (de) | Verfahren zur Herstellung hauptkettenpolysubstituierter Chelate | |
ATE82495T1 (de) | Verfahren zur herstellung pharmazeutischer mischungen. | |
ATE71375T1 (de) | Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen. | |
DE3867736D1 (de) | Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels. | |
ATA253881A (de) | Verfahren zur herstellung von neuen n-(vinblastin-23-oyl)-aminosaeurederivaten und von deren saeureadditionssalzen | |
ATE27967T1 (de) | Loesliche leber-uricase, verfahren zu ihrer herstellung und verwendung. | |
DE3881364D1 (de) | Verfahren zur herstellung und zusammensetzungen von kollagen-derivaten. | |
ATE43344T1 (de) | Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verf. zu ihrer herstellung u. pharmakologische zubereitungen, insb. zur behandlung von knochentumoren. | |
DE69529930T2 (de) | Verfahren zur Herstellung von 5-Aminolävulinsäure | |
DE58908590D1 (de) | Verfahren zur Herstellung von 4,5-Dichlor-6-ethylpyrimidin. | |
PT92952A (pt) | Processo para a preparacao de acidos 3-fenil-5,6-di-hidrobenz { c }acridina-7- carboxilicos, de compostos relacionados e de composicoes farmaceuticas que os contem | |
ATE20737T1 (de) | Verfahren zur herstellung von acemetacin. | |
NO883520D0 (no) | Fremgangsmaate for fremstilling av et injeksjonspreparat. | |
ATE67500T1 (de) | Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten. | |
DE3577443D1 (de) | Derivate von dihydroorotsaeure, deren verfahren zur herstellung und deren pharmazeutische zusammensetzungen. | |
ATE118008T1 (de) | Verfahren zur herstellung von aminomethanphosphonsäure und aminomethyl- phosphinsäuren. | |
DE69033833D1 (de) | Verfahren zur Herstellung von Butantetracarbonsäure | |
AT359076B (de) | Verfahren zur herstellung neuer 3-pyrazol-1-yl- pyridazin-derivate und der physiologisch ver- traeglichen saeureadditionssalze dieser ver- bindungen | |
DE69715053D1 (de) | Verfahren zur herstellung von inorganischen salzen von optisch aktiven phenylglycin-derivaten | |
ATE43342T1 (de) | Verfahren zur herstellung von hydrogeno- oder halogenosilanen. | |
DE2963730D1 (en) | 1,4-dihydropyridazine-3-carbonyl compounds, process for their preparation, the compounds for use in curing diseases, medicaments containing them and process for the preparation of the medicaments | |
ATA91186A (de) | Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen | |
DE3576506D1 (de) | Verfahren zur herstellung von alpha-aminoalkylphosphon- und von alpha-aminoalkylphosphinsaeuren. | |
ATE30155T1 (de) | Verfahren zur herstellung von azetidinsulfonsaeuren. | |
ATA373182A (de) | Verfahren zur herstellung neuer derivate des 20,21-dinoreburnamenins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: COULTER INTERNATIONAL CORP., MIAMI, FLA., US |
|
8381 | Inventor (new situation) |
Free format text: GANSOW, OTTO A., WASHINGTON, D.C., US BRECHBIEL, MARTIN W., ANNANDALE, VA., US |