ATE123059T1 - Menschliche, erythroid-spezifische transkriptionsenhancer. - Google Patents

Menschliche, erythroid-spezifische transkriptionsenhancer.

Info

Publication number
ATE123059T1
ATE123059T1 AT88909914T AT88909914T ATE123059T1 AT E123059 T1 ATE123059 T1 AT E123059T1 AT 88909914 T AT88909914 T AT 88909914T AT 88909914 T AT88909914 T AT 88909914T AT E123059 T1 ATE123059 T1 AT E123059T1
Authority
AT
Austria
Prior art keywords
specific transcription
human erythroid
transcription enhancers
enhancer element
erythroid
Prior art date
Application number
AT88909914T
Other languages
English (en)
Inventor
Dorothy Y H Tuan
Irving M London
William B Solomon
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE123059(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE123059T1 publication Critical patent/ATE123059T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
AT88909914T 1987-09-17 1988-09-15 Menschliche, erythroid-spezifische transkriptionsenhancer. ATE123059T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9802587A 1987-09-17 1987-09-17
US11367787A 1987-10-26 1987-10-26

Publications (1)

Publication Number Publication Date
ATE123059T1 true ATE123059T1 (de) 1995-06-15

Family

ID=26793935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88909914T ATE123059T1 (de) 1987-09-17 1988-09-15 Menschliche, erythroid-spezifische transkriptionsenhancer.

Country Status (7)

Country Link
US (1) US5126260A (de)
EP (1) EP0377676B1 (de)
JP (1) JP2779192B2 (de)
AT (1) ATE123059T1 (de)
CA (1) CA1341119C (de)
DE (1) DE3853886T2 (de)
WO (1) WO1989002469A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8718779D0 (en) * 1987-08-07 1987-09-16 Grosveld F G Dna sequence & expression vector
GB9027917D0 (en) * 1990-12-21 1991-02-13 Ici Plc Expression systems
US5756353A (en) * 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
US6627615B1 (en) 1991-12-17 2003-09-30 The Regents Of The University Of California Methods and compositions for in vivo gene therapy
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US6806084B1 (en) 1992-06-04 2004-10-19 The Regents Of The University Of California Methods for compositions for in vivo gene delivery
AU4528493A (en) * 1992-06-04 1994-01-04 Regents Of The University Of California, The In vivo gene therapy with intron-free sequence of interest
US5631162A (en) * 1993-06-11 1997-05-20 Massachusetts Institute Of Technology Retroviral vectors for transducing β-globin gene and β-locus control region derivatives
US6897016B1 (en) * 1993-11-12 2005-05-24 The Regents Of The University Of Colorado Alteration of sequence of a target molecule
EP0783575B1 (de) * 1994-09-19 1999-06-16 Massachusetts Institute Of Technology Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie
US6153427A (en) * 1994-10-12 2000-11-28 Northeastern Ohio Universities College Of Medicine Erythropoietin-inducible, erythroid-specific DNA construct
US6127345A (en) * 1997-01-21 2000-10-03 Smithkline Beecham Corporation Polynucleotides encoding the glucose 6-phosphate dehydrogenase of Streptococcus pneumoniae
EP1084278B1 (de) * 1998-06-08 2005-10-19 ACGT Medico Inc. Erkennung von dns, rns und proteinen
IL159371A0 (en) 2001-06-29 2004-06-01 Sloan Kettering Inst Cancer Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies
WO2008089396A1 (en) * 2007-01-19 2008-07-24 Invitrogen Corporation Compositions and methods for genetic manipulation and monitoring of cell lines
ES2325711B1 (es) * 2007-04-17 2010-06-17 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (Ciemat) Vectores de expresion que comprenden el promotor del gen pklr humano y su uso para la elaboracion de composiciones farmaceuticas destinadas a terapia genica somatica con expresion especifica en celulas eritroides.
US20140037599A1 (en) * 2012-08-03 2014-02-06 The Trustees Of The University Of Pennsylvania Compositions and Methods of Treating T Cell Deficiency
EP3445406B1 (de) 2016-04-20 2021-05-26 Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P. Zusammensetzungen und verfahren zur verbesserten genexpression von pklr
BR112020007444A2 (pt) 2017-10-16 2020-10-20 Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. vetores lentivirais para a liberação de pklr para tratar deficiência de piruvato quinase
AU2021320902A1 (en) 2020-08-07 2023-04-06 Spacecraft Seven, Llc Plakophilin-2 (PKP2) gene therapy using AAV vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789930B2 (ja) * 1984-03-08 1995-10-04 大正製薬株式会社 ウイルス性転写促進配列
US4663281A (en) * 1984-03-22 1987-05-05 Mass Institute Of Technology Enhanced production of proteinaceous materials in eucaryotic cells

Also Published As

Publication number Publication date
EP0377676A1 (de) 1990-07-18
WO1989002469A3 (en) 1989-04-20
DE3853886T2 (de) 1995-10-05
JPH03500245A (ja) 1991-01-24
JP2779192B2 (ja) 1998-07-23
WO1989002469A2 (en) 1989-03-23
EP0377676B1 (de) 1995-05-24
CA1341119C (en) 2000-10-17
US5126260A (en) 1992-06-30
DE3853886D1 (de) 1995-06-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time