DE3853886D1 - Menschliche, erythroid-spezifische transkriptionsenhancer. - Google Patents

Menschliche, erythroid-spezifische transkriptionsenhancer.

Info

Publication number
DE3853886D1
DE3853886D1 DE3853886T DE3853886T DE3853886D1 DE 3853886 D1 DE3853886 D1 DE 3853886D1 DE 3853886 T DE3853886 T DE 3853886T DE 3853886 T DE3853886 T DE 3853886T DE 3853886 D1 DE3853886 D1 DE 3853886D1
Authority
DE
Germany
Prior art keywords
erythroid
human
specific
transcribution
hancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3853886T
Other languages
English (en)
Other versions
DE3853886T2 (de
Inventor
Dorothy Tuan
Irving London
William Solomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3853886(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE3853886D1 publication Critical patent/DE3853886D1/de
Application granted granted Critical
Publication of DE3853886T2 publication Critical patent/DE3853886T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3853886T 1987-09-17 1988-09-15 Menschliche, erythroid-spezifische transkriptionsenhancer. Expired - Lifetime DE3853886T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9802587A 1987-09-17 1987-09-17
US11367787A 1987-10-26 1987-10-26
PCT/US1988/003187 WO1989002469A2 (en) 1987-09-17 1988-09-15 Human erythroid-specific transcriptional enhancer

Publications (2)

Publication Number Publication Date
DE3853886D1 true DE3853886D1 (de) 1995-06-29
DE3853886T2 DE3853886T2 (de) 1995-10-05

Family

ID=26793935

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853886T Expired - Lifetime DE3853886T2 (de) 1987-09-17 1988-09-15 Menschliche, erythroid-spezifische transkriptionsenhancer.

Country Status (7)

Country Link
US (1) US5126260A (de)
EP (1) EP0377676B1 (de)
JP (1) JP2779192B2 (de)
AT (1) ATE123059T1 (de)
CA (1) CA1341119C (de)
DE (1) DE3853886T2 (de)
WO (1) WO1989002469A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8718779D0 (en) * 1987-08-07 1987-09-16 Grosveld F G Dna sequence & expression vector
GB9027917D0 (en) * 1990-12-21 1991-02-13 Ici Plc Expression systems
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US6627615B1 (en) 1991-12-17 2003-09-30 The Regents Of The University Of California Methods and compositions for in vivo gene therapy
US5756353A (en) * 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
EP0646178A1 (de) * 1992-06-04 1995-04-05 The Regents Of The University Of California Expression kassette mit im säugetier wirt funktionnellen regulator sequenzen
US6806084B1 (en) 1992-06-04 2004-10-19 The Regents Of The University Of California Methods for compositions for in vivo gene delivery
US5631162A (en) * 1993-06-11 1997-05-20 Massachusetts Institute Of Technology Retroviral vectors for transducing β-globin gene and β-locus control region derivatives
US6897016B1 (en) * 1993-11-12 2005-05-24 The Regents Of The University Of Colorado Alteration of sequence of a target molecule
DE69510356D1 (de) * 1994-09-19 1999-07-22 Massachusetts Inst Technology Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie
US6153427A (en) * 1994-10-12 2000-11-28 Northeastern Ohio Universities College Of Medicine Erythropoietin-inducible, erythroid-specific DNA construct
US6127345A (en) * 1997-01-21 2000-10-03 Smithkline Beecham Corporation Polynucleotides encoding the glucose 6-phosphate dehydrogenase of Streptococcus pneumoniae
WO1999064628A1 (en) * 1998-06-08 1999-12-16 Acgt Medico, Inc. Detection of dna, rna and proteins
ATE535260T1 (de) 2001-06-29 2011-12-15 Sloan Kettering Inst Cancer Vektor kodierend humanes globin-gen und seine verwendung bei der behandlung von hämoglobinopathien
US20080216185A1 (en) * 2007-01-19 2008-09-04 Invitrogen Corporation Compositions and Methods for Genetic Manipulation and Monitoring of Cell Lines
ES2325711B1 (es) * 2007-04-17 2010-06-17 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (Ciemat) Vectores de expresion que comprenden el promotor del gen pklr humano y su uso para la elaboracion de composiciones farmaceuticas destinadas a terapia genica somatica con expresion especifica en celulas eritroides.
US20140037599A1 (en) * 2012-08-03 2014-02-06 The Trustees Of The University Of Pennsylvania Compositions and Methods of Treating T Cell Deficiency
KR20240096679A (ko) 2016-04-20 2024-06-26 센트로 데 인베스띠가씨오네스 에너제티까스 메디오암비엔딸레스 와이 테크놀로지까스, 오.에이., 엠.피. Pklr의 유전자 발현 증강을 위한 조성물 및 방법
BR112020007444A2 (pt) 2017-10-16 2020-10-20 Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. vetores lentivirais para a liberação de pklr para tratar deficiência de piruvato quinase
WO2021150987A1 (en) * 2020-01-22 2021-07-29 Altius Institute For Biomedical Sciences Novel erythroid specific enhancers and uses thereof
IL300263A (en) 2020-08-07 2023-03-01 Spacecraft Seven Llc Plakophilin-2 (PKP2) gene therapy using an AAV vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789930B2 (ja) * 1984-03-08 1995-10-04 大正製薬株式会社 ウイルス性転写促進配列
US4663281A (en) * 1984-03-22 1987-05-05 Mass Institute Of Technology Enhanced production of proteinaceous materials in eucaryotic cells

Also Published As

Publication number Publication date
US5126260A (en) 1992-06-30
EP0377676A1 (de) 1990-07-18
WO1989002469A2 (en) 1989-03-23
JPH03500245A (ja) 1991-01-24
EP0377676B1 (de) 1995-05-24
WO1989002469A3 (en) 1989-04-20
ATE123059T1 (de) 1995-06-15
CA1341119C (en) 2000-10-17
JP2779192B2 (ja) 1998-07-23
DE3853886T2 (de) 1995-10-05

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Legal Events

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8363 Opposition against the patent