ATE119784T1 - Markierte chemotaktische peptide zur visualisierung von entzündungs- oder infektionsstellen. - Google Patents

Markierte chemotaktische peptide zur visualisierung von entzündungs- oder infektionsstellen.

Info

Publication number
ATE119784T1
ATE119784T1 AT90108734T AT90108734T ATE119784T1 AT E119784 T1 ATE119784 T1 AT E119784T1 AT 90108734 T AT90108734 T AT 90108734T AT 90108734 T AT90108734 T AT 90108734T AT E119784 T1 ATE119784 T1 AT E119784T1
Authority
AT
Austria
Prior art keywords
chemotactic peptides
visualizing
inflammatory
infection sites
labeled chemotactic
Prior art date
Application number
AT90108734T
Other languages
English (en)
Inventor
Alan Jay Fischman
Robert Harold Rubin
Harry William Strauss
Anthony Joseph Fuccello
Daniel John Kroon
Douglas James Riexinger
Original Assignee
Gen Hospital Corp
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Ortho Pharma Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE119784T1 publication Critical patent/ATE119784T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
AT90108734T 1989-05-09 1990-05-09 Markierte chemotaktische peptide zur visualisierung von entzündungs- oder infektionsstellen. ATE119784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34918689A 1989-05-09 1989-05-09

Publications (1)

Publication Number Publication Date
ATE119784T1 true ATE119784T1 (de) 1995-04-15

Family

ID=23371254

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90108734T ATE119784T1 (de) 1989-05-09 1990-05-09 Markierte chemotaktische peptide zur visualisierung von entzündungs- oder infektionsstellen.

Country Status (14)

Country Link
EP (1) EP0398143B1 (de)
JP (1) JP2931093B2 (de)
KR (1) KR0185995B1 (de)
AT (1) ATE119784T1 (de)
AU (1) AU644364B2 (de)
CA (1) CA2016235C (de)
DE (1) DE69017751T2 (de)
DK (1) DK0398143T3 (de)
ES (1) ES2072329T3 (de)
FI (1) FI106467B (de)
NO (1) NO309326B1 (de)
NZ (2) NZ314680A (de)
WO (1) WO1990013317A1 (de)
ZA (1) ZA903517B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
CA2065299C (en) * 1989-08-09 2001-07-24 Buck A. Rhodes Direct radiolabeling of antibodies and other proteins with technetium or rhenium
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
WO1993012819A1 (en) * 1992-01-03 1993-07-08 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
DE69332879T2 (de) * 1992-03-13 2004-02-19 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
US5605671A (en) * 1992-10-05 1997-02-25 The Regents Of The University Of Michigan Radiolabeled neutrophil activating peptides for imaging
US5413778A (en) * 1992-10-05 1995-05-09 The Regents Of The University Of Michigan Labelled monocyte chemoattractant protein material and medical uses thereof
WO1994009128A1 (en) * 1992-10-22 1994-04-28 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
EP0709100A1 (de) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Kontrastmittel mit mehreren Detektionsgruppen pro Molekül
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
WO1997014443A1 (en) * 1995-10-19 1997-04-24 Bracco International B.V. Magnetically labeled chemoattractants as targeted contrast agents in the nmr imaging of living tissues
DE69628731T3 (de) * 1995-11-01 2012-09-20 Bracco Suisse S.A. Gezielte magnetisch markierte molekularmarkersysteme als nmr-bilderzeugungsmittel
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
WO1999025372A1 (en) 1997-11-13 1999-05-27 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
US6872536B1 (en) * 1998-11-10 2005-03-29 Bracco Imaging S.P.A. Chemotactic peptide antagonists for imaging sites of inflammation
HK1044468A1 (zh) * 1998-12-03 2002-10-25 海斯塔泰克有限责任公司 治療哮喘和炎症的小肽和方法
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
WO2003031461A2 (en) * 2001-10-05 2003-04-17 United States Of America As Represented By The Secretary Of The Navy N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response
NZ538869A (en) * 2002-09-27 2006-09-29 Nihon Mediphysics Co Ltd Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CA2772767C (en) 2011-03-30 2019-02-26 Kyoto University Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004351A1 (en) * 1986-01-16 1987-07-30 The General Hospital Corporation Method for the diagnosis and treatment of inflammation

Also Published As

Publication number Publication date
FI106467B (fi) 2001-02-15
DE69017751D1 (de) 1995-04-20
ES2072329T3 (es) 1995-07-16
AU644364B2 (en) 1993-12-09
CA2016235A1 (en) 1990-11-09
FI915249A0 (fi) 1991-11-06
AU5659090A (en) 1990-11-29
KR920700700A (ko) 1992-08-10
DE69017751T2 (de) 1995-07-13
NZ233601A (en) 1997-06-24
JP2931093B2 (ja) 1999-08-09
KR0185995B1 (ko) 1999-05-01
NO914354D0 (no) 1991-11-07
NO914354L (no) 1992-01-07
CA2016235C (en) 2002-03-12
EP0398143A1 (de) 1990-11-22
ZA903517B (en) 1991-03-27
JPH04505761A (ja) 1992-10-08
NO309326B1 (no) 2001-01-15
EP0398143B1 (de) 1995-03-15
DK0398143T3 (da) 1995-05-22
WO1990013317A1 (en) 1990-11-15
NZ314680A (en) 2000-08-25

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