ATE90108T1 - Vasokonstriktor-peptid. - Google Patents
Vasokonstriktor-peptid.Info
- Publication number
- ATE90108T1 ATE90108T1 AT88115674T AT88115674T ATE90108T1 AT E90108 T1 ATE90108 T1 AT E90108T1 AT 88115674 T AT88115674 T AT 88115674T AT 88115674 T AT88115674 T AT 88115674T AT E90108 T1 ATE90108 T1 AT E90108T1
- Authority
- AT
- Austria
- Prior art keywords
- vasoconstrictor
- endothelin
- present
- vasoconstrictor peptide
- serum
- Prior art date
Links
- 239000005526 vasoconstrictor agent Substances 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000002045 Endothelin Human genes 0.000 abstract 2
- 108050009340 Endothelin Proteins 0.000 abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 239000012679 serum free medium Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25538187 | 1987-10-09 | ||
| EP88115674A EP0310887B1 (de) | 1987-10-09 | 1988-09-23 | Vasokonstriktor-Peptid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE90108T1 true ATE90108T1 (de) | 1993-06-15 |
Family
ID=17277972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88115674T ATE90108T1 (de) | 1987-10-09 | 1988-09-23 | Vasokonstriktor-peptid. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4981950A (de) |
| EP (1) | EP0310887B1 (de) |
| AT (1) | ATE90108T1 (de) |
| DE (1) | DE3881467T2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231166A (en) * | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
| CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
| WO1992002237A1 (en) * | 1990-08-08 | 1992-02-20 | The Rockefeller University | Analogs of endothelin |
| FR2669339B1 (fr) * | 1990-11-21 | 1995-03-03 | Roussel Uclaf | Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives. |
| JPH06505474A (ja) * | 1991-01-31 | 1994-06-23 | アボツト・ラボラトリーズ | エンドセリン転換酵素阻害剤 |
| CA2104860A1 (en) * | 1991-03-08 | 1992-09-09 | Thomas T. Andersen | Endothelin antagonists |
| US5382569A (en) * | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
| US5260276A (en) * | 1991-06-14 | 1993-11-09 | Warner-Lambert Company | Linear and monocyclic endothelin antagonists |
| PL176250B1 (pl) * | 1991-11-05 | 1999-05-31 | Smithkline Beecham Corp | Sposób wytwarzania pochodnych indanu |
| TW299333B (de) * | 1992-12-29 | 1997-03-01 | Takeda Pharm Industry Co Ltd | |
| AU3290302A (en) * | 2000-10-20 | 2002-04-29 | Univ Tulane | Urotensin-ii agonists and antagonists |
| AU2007230887A1 (en) * | 2006-03-23 | 2007-10-04 | Amylin Pharmaceuticals, Inc. | Endothelin and endothelin receptor agonists in the treatment of metabolic diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496544A (en) * | 1983-11-10 | 1985-01-29 | Washington University | Atrial Peptides |
| US4557864A (en) * | 1984-01-10 | 1985-12-10 | Washington University | Atrial peptides |
| US4618600A (en) * | 1984-04-19 | 1986-10-21 | Biotechnology Research Associates, J.V. | Novel polypeptide diuretic/vasodilators |
| US4716147A (en) * | 1986-03-27 | 1987-12-29 | Monsanto Company | Synthetic airial peptides |
-
1988
- 1988-09-23 DE DE88115674T patent/DE3881467T2/de not_active Expired - Lifetime
- 1988-09-23 AT AT88115674T patent/ATE90108T1/de not_active IP Right Cessation
- 1988-09-23 EP EP88115674A patent/EP0310887B1/de not_active Expired - Lifetime
- 1988-09-26 US US07/249,429 patent/US4981950A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0310887A3 (en) | 1990-07-18 |
| DE3881467T2 (de) | 1993-10-21 |
| EP0310887B1 (de) | 1993-06-02 |
| US4981950A (en) | 1991-01-01 |
| EP0310887A2 (de) | 1989-04-12 |
| DE3881467D1 (de) | 1993-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |