ATE106725T1 - Verwendung von selektiven gaba-b-agonisten als antitussiva. - Google Patents

Verwendung von selektiven gaba-b-agonisten als antitussiva.

Info

Publication number
ATE106725T1
ATE106725T1 AT91902534T AT91902534T ATE106725T1 AT E106725 T1 ATE106725 T1 AT E106725T1 AT 91902534 T AT91902534 T AT 91902534T AT 91902534 T AT91902534 T AT 91902534T AT E106725 T1 ATE106725 T1 AT E106725T1
Authority
AT
Austria
Prior art keywords
antitusives
agonists
selective gaba
gaba
mammal
Prior art date
Application number
AT91902534T
Other languages
English (en)
Inventor
William Kreutner
Donald Bolser
Richard Chapman
Sultan Aziz
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE106725T1 publication Critical patent/ATE106725T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AT91902534T 1989-12-20 1990-12-18 Verwendung von selektiven gaba-b-agonisten als antitussiva. ATE106725T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/454,786 US5006560A (en) 1989-12-20 1989-12-20 Use of GABA-B selective agonists as anti-tussive agents

Publications (1)

Publication Number Publication Date
ATE106725T1 true ATE106725T1 (de) 1994-06-15

Family

ID=23806078

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902534T ATE106725T1 (de) 1989-12-20 1990-12-18 Verwendung von selektiven gaba-b-agonisten als antitussiva.

Country Status (14)

Country Link
US (1) US5006560A (de)
EP (1) EP0506853B1 (de)
JP (1) JPH06102630B2 (de)
KR (1) KR950007208B1 (de)
AT (1) ATE106725T1 (de)
AU (1) AU642969B2 (de)
CA (1) CA2071981C (de)
DE (1) DE69009778T2 (de)
DK (1) DK0506853T3 (de)
ES (1) ES2055587T3 (de)
FI (1) FI922798A (de)
HU (1) HU212271B (de)
OA (1) OA09702A (de)
WO (1) WO1991008740A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214054A (en) * 1988-05-18 1993-05-25 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
US5231106A (en) * 1988-05-18 1993-07-27 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
US5229404A (en) * 1988-05-18 1993-07-20 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
US5182266A (en) * 1990-01-31 1993-01-26 Abbott Laboratories Method for treating renal disease
FR2662354B1 (fr) * 1990-05-23 1994-10-07 Adir Utilisation du baclofene pour l'obtention de medicaments destines au traitement de l'angine de poitrine.
GB9117716D0 (en) * 1991-08-16 1991-10-02 Lynxvale Ltd Gaba derivatives and their therapeutic application
US6194460B1 (en) * 1995-05-31 2001-02-27 Montefiore Medical Center Composition for treating cough induced by angiotensin converting enzyme inhibitors
DE69738396T2 (de) * 1996-05-24 2008-12-04 Smithkline Beecham Corp. Verwendung von gaba-aufnahme-inhibitoren als mittel gegen husten
ES2221385T3 (es) * 1998-05-15 2004-12-16 Warner-Lambert Company Llc Preparaciones de gabapentina y pregabalina estabilizadas con aminoacidos y procedimiento para prepararlas.
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
BRPI0413756A (pt) * 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
EP2354120A1 (de) 2003-08-20 2011-08-10 XenoPort, Inc. Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon
WO2006050471A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US20060160777A1 (en) * 2004-12-27 2006-07-20 Anders Lehmann New use of GABAbeta receptor agonists
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
ATE511392T1 (de) * 2007-01-11 2011-06-15 Xenoport Inc Verzögert freigesetzte orale dosierungsformen eines prodrugs von r-baclofen und behandlungsverfahren damit
US20090118365A1 (en) * 2007-11-06 2009-05-07 Xenoport, Inc Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
WO2009094569A2 (en) * 2008-01-25 2009-07-30 Xenoport, Inc. Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates
WO2009094563A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
US9623000B2 (en) 2008-07-31 2017-04-18 Dekel Pharmaceuticals Ltd Compositions and methods for treating inflammatory disorders
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
EP2403486A1 (de) 2009-03-03 2012-01-11 XenoPort, Inc. Orale dosierformen eines r-baclofen-prodrugs mit verzögerter freisetzung
US8344028B2 (en) * 2009-04-17 2013-01-01 Xenoport, Inc. Gamma-amino-butyric acid derivatives as GABAB receptor ligands
WO2013023155A1 (en) 2011-08-11 2013-02-14 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH449645A (de) * 1963-07-09 1968-01-15 Ciba Geigy Verfahren zur Herstellung neuer Aminosäuren

Also Published As

Publication number Publication date
CA2071981A1 (en) 1991-06-21
ES2055587T3 (es) 1994-08-16
KR920703043A (ko) 1992-12-17
FI922798A0 (fi) 1992-06-17
EP0506853B1 (de) 1994-06-08
CA2071981C (en) 2002-06-25
FI922798A (fi) 1992-06-17
AU7174591A (en) 1991-07-18
JPH06102630B2 (ja) 1994-12-14
US5006560A (en) 1991-04-09
JPH05504764A (ja) 1993-07-22
HUT61194A (en) 1992-12-28
DE69009778T2 (de) 1994-09-22
AU642969B2 (en) 1993-11-04
HU9202077D0 (en) 1992-09-28
WO1991008740A1 (en) 1991-06-27
OA09702A (en) 1993-08-30
DK0506853T3 (da) 1994-08-01
DE69009778D1 (de) 1994-07-14
KR950007208B1 (ko) 1995-07-04
EP0506853A1 (de) 1992-10-07
HU212271B (en) 1996-04-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee