ATA509077A - Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbon- saeureestern und -salzen - Google Patents

Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbon- saeureestern und -salzen

Info

Publication number
ATA509077A
ATA509077A AT509077A AT509077A ATA509077A AT A509077 A ATA509077 A AT A509077A AT 509077 A AT509077 A AT 509077A AT 509077 A AT509077 A AT 509077A AT A509077 A ATA509077 A AT A509077A
Authority
AT
Austria
Prior art keywords
aroyl
pyrrol
pyrrolo
dihydro
salts
Prior art date
Application number
AT509077A
Other languages
English (en)
Other versions
AT363465B (de
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24831341&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATA509077(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Priority to AT402479A priority Critical patent/AT364844B/de
Priority to AT573780A priority patent/AT369003B/de
Publication of ATA509077A publication Critical patent/ATA509077A/de
Application granted granted Critical
Publication of AT363465B publication Critical patent/AT363465B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT0509077A 1976-07-14 1977-07-14 Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbonsaeureestern und -salzen AT363465B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT402479A AT364844B (de) 1976-07-14 1979-06-01 Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbonsaeuren und ihren salzen
AT573780A AT369003B (de) 1976-07-14 1980-11-24 Verfahren zur herstellung von neuen 5-aroyl-1,2dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-carbons[ure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14

Publications (2)

Publication Number Publication Date
ATA509077A true ATA509077A (de) 1981-01-15
AT363465B AT363465B (de) 1981-08-10

Family

ID=24831341

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0509077A AT363465B (de) 1976-07-14 1977-07-14 Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbonsaeureestern und -salzen

Country Status (7)

Country Link
US (1) US4089969A (de)
JP (1) JPS61191686A (de)
AT (1) AT363465B (de)
BE (1) BE856681A (de)
NO (1) NO1994007I1 (de)
SU (2) SU946403A3 (de)
ZA (1) ZA774238B (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4410534A (en) * 1979-12-26 1983-10-18 Syntex (U.S.A.) Inc. 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4456759A (en) * 1980-10-20 1984-06-26 Syntex (U.S.A.) Inc. 5-Benzoyl-7-halo-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1,1-dicarboxylic acids and esters thereof
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4560699A (en) * 1983-01-17 1985-12-24 Syntex (U.S.A.) Inc. 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
US4496741A (en) * 1983-01-24 1985-01-29 Merck & Co., Inc. Process for the preparation of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivative
EP0117675B1 (de) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran- und Benzothiophencarbonsäurederivate
US4622407A (en) * 1984-04-26 1986-11-11 Merck & Co., Inc. Resolution of racemic derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-2-carboxylic acid and analogs
US4988822A (en) * 1986-05-29 1991-01-29 Syntex (U.S.A.) Inc. Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates
US4873340A (en) * 1986-05-29 1989-10-10 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4937368A (en) * 1987-01-14 1990-06-26 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
WO1989005798A1 (en) * 1987-12-18 1989-06-29 Ciba-Geigy Ag TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US5464609A (en) * 1990-03-16 1995-11-07 The Procter & Gamble Company Use of ketorolac for treatment of oral diseases and conditions
IT1241124B (it) * 1990-04-20 1993-12-29 Industriale Chimica Processo per la preparazione di derivati di acidi 1,2-diidro 3h pirrol (1,2-a) pirrol-l-carbossilici e relativi intermedi
US5091182A (en) * 1990-07-23 1992-02-25 Syntex (U.S.A.) Inc. Dispensing units for ketorolac topical gel formlations
US5082951A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor
US5082950A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
WO1993009768A1 (en) * 1991-11-11 1993-05-27 Hisamitsu Pharmaceutical Co., Inc. Fomentation containing ketorolac
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
ES2199954T3 (es) * 1992-11-09 2004-03-01 Neurogesx, Inc. Administracion transdermica de cetorolac.
US5883115A (en) * 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5382591A (en) * 1992-12-17 1995-01-17 Sepracor Inc. Antipyretic and analgesic methods using optically pure R-ketorolac
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
WO1995001767A1 (en) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
KR0140134B1 (ko) * 1994-11-16 1998-06-01 강재헌 피롤리진 유도체의 제조방법
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
US5912351A (en) * 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof
US5696139A (en) * 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
KR100303377B1 (ko) * 1996-05-30 2001-12-12 프리돌린 클라우스너, 롤란드 비. 보레르 신규피롤유도체
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
EP1097152B1 (de) * 1998-07-10 2006-04-19 Mallinckrodt Inc. Synthese von verbindungen die zur herstellung von ketorolac dienen
US6197976B1 (en) 1998-12-14 2001-03-06 Syntex (U.S.A.) Llc Preparation of ketorolac
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
US6552020B1 (en) * 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
US6403594B1 (en) 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
EP2153819B1 (de) 2000-07-14 2012-09-05 Allergan, Inc. Verwendung von einem Löslichkeitsvermittler in einer wässerigen Zusammensetzung enthaltend Brimonidintartrat
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
US20030027867A1 (en) * 2001-06-29 2003-02-06 Myriad Genetics, Incorporated Use of R-NSAID compounds for anti-HIV treatment
KR100400885B1 (ko) * 2001-07-20 2003-10-17 경동제약 주식회사 라세미체의 케토로락을 단일이성체로 분리하는 방법
US20030191187A1 (en) * 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
BRPI0302736B8 (pt) 2003-06-02 2021-05-25 Ems S/A composição farmacêutica a base de cetorolaco ou de um de seus sais farmaceuticamente aceitáveis para uso sublingual
CA2468664C (en) 2003-06-03 2012-03-06 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
AU2004311577A1 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
DK1654002T4 (da) 2003-08-07 2014-02-17 Allergan Inc Sammensætninger til fremføring af terapeutiske midler til øjnene
US20050171207A1 (en) * 2003-09-26 2005-08-04 Myriad Genetics, Incorporated Method and composition for combination treatment of neurodegenerative disorders
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
US20050252144A1 (en) * 2004-04-29 2005-11-17 Macdonald Robert A Veneers for walls, retaining walls and the like
BRPI0514303A (pt) * 2004-08-11 2008-06-10 Myriad Genetics Inc composição farmacêutica e método para tratar distúrbios neurodegenerativos
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
AU2005322305B2 (en) * 2004-12-23 2010-09-16 Roxro Pharma, Inc. Therapeutic compositions for intranasal administration of ketorolac
US20070015832A1 (en) * 2005-07-14 2007-01-18 Myriad Genetics, Incorporated Methods of treating overactive bladder and urinary incontinence
CA2615063A1 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
US20100010046A1 (en) * 2006-06-12 2010-01-14 Ironwood Pharmaceuticals, Inc. Pharmaceutical formulation for parenteral administration
US20080033045A1 (en) * 2006-07-07 2008-02-07 Myriad Genetics, Incorporated Treatment of psychiatric disorders
US9192571B2 (en) * 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
US7842714B2 (en) * 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
TW201002368A (en) * 2008-06-13 2010-01-16 Roxro Pharma Inc Unit dose formulations of ketorolac for intranasal administration
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
US8551454B2 (en) * 2009-03-13 2013-10-08 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
EP2555750A2 (de) 2010-04-07 2013-02-13 Allergan, Inc. Kombinationen aus konservierungsstoffzusammensetzungen für ophthalmische formulierungen
WO2011127151A2 (en) 2010-04-07 2011-10-13 Allergan, Inc. Combinations of preservatives for ophthalmic compositions
KR20140012029A (ko) 2010-10-21 2014-01-29 알티유 파머수티컬즈, 엘엘시 즉시 사용가능한 케토로락 제제
WO2012127497A1 (en) 2011-03-04 2012-09-27 Cadila Healthcare Limited Stable pharmaceutical compositions of ketorolac or salts thereof
IL256819A (en) 2017-01-09 2018-02-28 Steadymed Ltd Enhanced stability ketorolac formulations and methods and devices for use with same
CA2991391A1 (en) 2017-01-09 2018-07-09 Steadymed, Ltd. Dose sparing ketorolac formulations and methods and devices for use withsame
WO2018197932A1 (en) 2017-04-27 2018-11-01 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions of ketorolac
MX2018000963A (es) 2018-01-22 2018-12-13 Federico Amezcua Amezcua Composicion farmaceutica sinergica del enantiomero activo s-ketorolaco trometamina y clorhidrato de tramadol.
JP7229012B2 (ja) * 2018-12-25 2023-02-27 小林製薬株式会社 内服用医薬組成物
MX2019008467A (es) 2019-07-16 2019-11-07 Federico Amezcua Amezcua Combinacion sinergica de s-ketorolaco y pregabalina en una composicion farmaceutica para el tratamiento del dolor neuropatico.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (de) * 1962-06-07

Also Published As

Publication number Publication date
BE856681A (fr) 1978-01-11
JPS61191686A (ja) 1986-08-26
AT363465B (de) 1981-08-10
SU946403A3 (ru) 1982-07-23
NO1994007I1 (no) 1994-07-29
ZA774238B (en) 1979-02-28
JPS6254792B2 (de) 1987-11-17
US4089969A (en) 1978-05-16
SU1151211A3 (ru) 1985-04-15

Similar Documents

Publication Publication Date Title
AT363465B (de) Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbonsaeureestern und -salzen
AT363464B (de) Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeureestern und -salzen
AT357143B (de) Verfahren zur herstellung von neuen substi- tuierten 3-phenoxy-2-hydroxy-1-aminopropanen sowie deren saeureadditionssalzen
AT361932B (de) Verfahren zur herstellung von neuen piperazin-1 -yl-acethydroxamsaeuren und deren salzen
AT367430B (de) Verfahren zur herstellung von neuen hydroxylamino-hydrocarbylphosphonsaeurederivaten
AT360533B (de) Verfahren zur herstellung von neuen trans- -hexahydropyrido-indolen und ihren saeure- additionssalzen
AT364360B (de) Verfahren zur herstellung von neuen pyridinyl-aminoalkylaethern und ihrer saeureadditionssalze
AT354436B (de) Verfahren zur herstellung von neuem 2-brom-6- fluor-n-2-imidazolidinyliden-benzamin und dessen saeureadditionssalzen
AT359994B (de) Verfahren zur herstellung von neuen benzoe- saeurederivaten und acylophenonen
AT354626B (de) Verfahren zur herstellung von neuen 7-acyl- amino-8-oxo-3-oxa-1-azabicyclo/4.2.0/octan-2- carbonsaeure-derivaten
AT353248B (de) Verfahren zur herstellung von neuen 3-poly- halogenaethyl-2,2-dimethylcyclopropancarbon- saeureestern
AT357152B (de) Verfahren zur herstellung von neuen n-cyclo- alkylmethyl-2-phenylamino-imidazolinen-(2) und ihren saeureadditionssalzen
AT365170B (de) Verfahren zur herstellung von neuen 13-thiaprostansaeurederivaten
AT351509B (de) Verfahren zur herstellung von neuen 3-phenoxy-2 -hydroxy-1-phenoxy- oder -1-phenylthioalkyl- amino-propanen und von deren saeureadditions- salzen
AT358046B (de) Verfahren zur herstellung von neuen trans-5a- -aryl-decahydrobenzazepinen und ihren saeure- additionssalzen
AT357692B (de) Verfahren zur herstellung von 4-desacetoxy- -vinblastin und dessen saeureadditionssalzen
ATA402479A (de) Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbon- saeuren und ihren salzen
AT359993B (de) Verfahren zur herstellung von neuen substi- tuierten phenoxycarbonylphenyl-trans- -cyclohexancarbonsaeureestern
ATA5381A (de) Verfahren zur herstellung von neuen 13-thiaprostansaeurederivaten
ATA564679A (de) Verfahren zur herstellung von neuen hydroxylamino-hydrocarbylphosphonsaeurederivaten
AT372083B (de) Verfahren zur herstellung von neuen aminoalkylheterocyclen und ihren saeureadditionssalzen
AT363941B (de) Verfahren zur herstellung von neuen aminoalkylheterocyclen und ihren saeureadditionssalzen
AT363942B (de) Verfahren zur herstellung von neuen aminoalkylheterocyclen und ihren saeureadditionssalzen
ATA20680A (de) Verfahren zur herstellung von neuen aminoalkylheterocyclen und ihren saeureadditionssalzen
ATA179879A (de) Verfahren zur herstellung von neuen estern und von deren saeureadditionssalzen

Legal Events

Date Code Title Description
EZF Grant of a certificate of protection

Free format text: SZ 33/1997, 19970728, EXPIRES:20040115

SZA Application filed for a certificate of protection

Free format text: SZ 33/1997, 19970728

ELA Expired due to lapse of time