ATA204083A - Verfahren zur herstellung von neuen, in 2-stellung substituierten derivaten der 4-hydroxy-3- chinolin-carbonsaeure - Google Patents
Verfahren zur herstellung von neuen, in 2-stellung substituierten derivaten der 4-hydroxy-3- chinolin-carbonsaeureInfo
- Publication number
- ATA204083A ATA204083A AT0204083A AT204083A ATA204083A AT A204083 A ATA204083 A AT A204083A AT 0204083 A AT0204083 A AT 0204083A AT 204083 A AT204083 A AT 204083A AT A204083 A ATA204083 A AT A204083A
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- production
- carbonic acid
- acid substituted
- new derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8209654A FR2530633A1 (fr) | 1982-06-03 | 1982-06-03 | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA204083A true ATA204083A (de) | 1987-07-15 |
| AT385034B AT385034B (de) | 1988-02-10 |
Family
ID=9274589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0204083A AT385034B (de) | 1982-06-03 | 1983-06-03 | Verfahren zur herstellung von neuen, in 2-stellung substituierten derivaten der 4-hydroxy-3- chinolin-carbonsaeure |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US4486438A (de) |
| JP (1) | JPS58225066A (de) |
| AT (1) | AT385034B (de) |
| BE (1) | BE896941A (de) |
| CA (1) | CA1204116A (de) |
| CH (2) | CH659469A5 (de) |
| DE (1) | DE3320102A1 (de) |
| FR (1) | FR2530633A1 (de) |
| GB (1) | GB2123817B (de) |
| IT (1) | IT1174760B (de) |
| LU (1) | LU84841A1 (de) |
| NL (1) | NL8301963A (de) |
| SE (2) | SE461041B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2553769B1 (fr) * | 1983-10-20 | 1986-03-14 | Roussel Uclaf | Nouveau procede de preparation de derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 |
| FR2564835B1 (fr) * | 1984-05-23 | 1986-10-24 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par un groupement soufre, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
| US4845105A (en) * | 1984-10-30 | 1989-07-04 | Roussel Uclaf | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity |
| FR2585356B1 (fr) * | 1985-07-25 | 1987-10-23 | Roussel Uclaf | Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant |
| FR2572404B2 (fr) * | 1984-10-30 | 1987-12-11 | Roussel Uclaf | Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| JPH04503820A (ja) * | 1989-12-04 | 1992-07-09 | ウラルスキ ポリテフニチェスキ インスティテュト イメニ エス．エム．キロバ | 縮合されたテトラヒドロキノキサリンのカルボン酸のボルニル及びイソボルニルエステル |
| GT200600180A (es) * | 2005-04-29 | 2006-11-22 | Proceso para preparar isatinas con control de formacion de subproductos | |
| US9139529B2 (en) * | 2013-01-31 | 2015-09-22 | Vertex Pharmaceuticals Incorporated | Substituted quinoxalines as sodium channel modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB610619A (en) * | 1945-05-17 | 1948-10-19 | Rhone Poulenc Sa | Process for the separation of isomeric substituted quinoline carboxylic acids and esters thereof |
| GB1007331A (en) * | 1960-12-01 | 1965-10-13 | Fisons Pest Control Ltd | Quinazolin-3-oxides and benzo-1,2,3-triazine-3-oxides |
| US3491138A (en) * | 1964-06-26 | 1970-01-20 | American Home Prod | Benzodiazepine intermediates |
| FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2482596A1 (fr) * | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
-
1982
- 1982-06-03 FR FR8209654A patent/FR2530633A1/fr active Granted
-
1983
- 1983-05-02 SE SE8302474A patent/SE461041B/sv not_active IP Right Cessation
- 1983-05-27 US US06/498,832 patent/US4486438A/en not_active Expired - Fee Related
- 1983-05-27 IT IT48390/83A patent/IT1174760B/it active
- 1983-06-02 GB GB08315132A patent/GB2123817B/en not_active Expired
- 1983-06-02 NL NL8301963A patent/NL8301963A/xx not_active Application Discontinuation
- 1983-06-02 BE BE0/210919A patent/BE896941A/fr not_active IP Right Cessation
- 1983-06-02 CH CH3034/83A patent/CH659469A5/fr not_active IP Right Cessation
- 1983-06-02 LU LU84841A patent/LU84841A1/fr unknown
- 1983-06-02 CH CH731/86A patent/CH659818A5/fr not_active IP Right Cessation
- 1983-06-02 CA CA000429562A patent/CA1204116A/fr not_active Expired
- 1983-06-03 AT AT0204083A patent/AT385034B/de not_active IP Right Cessation
- 1983-06-03 JP JP58098188A patent/JPS58225066A/ja active Granted
- 1983-06-03 DE DE19833320102 patent/DE3320102A1/de active Granted
-
1984
- 1984-06-22 US US06/623,430 patent/US4596875A/en not_active Expired - Fee Related
-
1986
- 1986-12-23 US US06/945,777 patent/US4736033A/en not_active Expired - Fee Related
-
1987
- 1987-10-08 SE SE8703886A patent/SE466656B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2123817B (en) | 1985-09-04 |
| SE8703886L (sv) | 1987-10-08 |
| GB8315132D0 (en) | 1983-07-06 |
| BE896941A (fr) | 1983-12-02 |
| IT1174760B (it) | 1987-07-01 |
| US4736033A (en) | 1988-04-05 |
| CA1204116A (fr) | 1986-05-06 |
| FR2530633B1 (de) | 1984-12-28 |
| SE8703886D0 (sv) | 1987-10-08 |
| CH659818A5 (fr) | 1987-02-27 |
| CH659469A5 (fr) | 1987-01-30 |
| JPH0354658B2 (de) | 1991-08-20 |
| SE8302474D0 (sv) | 1983-05-02 |
| GB2123817A (en) | 1984-02-08 |
| FR2530633A1 (fr) | 1984-01-27 |
| AT385034B (de) | 1988-02-10 |
| SE8302474L (sv) | 1983-12-04 |
| US4596875A (en) | 1986-06-24 |
| NL8301963A (nl) | 1984-01-02 |
| LU84841A1 (fr) | 1984-03-07 |
| JPS58225066A (ja) | 1983-12-27 |
| SE466656B (sv) | 1992-03-16 |
| US4486438A (en) | 1984-12-04 |
| SE461041B (sv) | 1989-12-18 |
| DE3320102A1 (de) | 1983-12-08 |
| DE3320102C2 (de) | 1992-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| UEP | Publication of translation of european patent specification |