ATA137799A - Faktor x-analogon mit verbesserter aktivierbarkeit - Google Patents
Faktor x-analogon mit verbesserter aktivierbarkeitInfo
- Publication number
- ATA137799A ATA137799A AT0137799A AT137799A ATA137799A AT A137799 A ATA137799 A AT A137799A AT 0137799 A AT0137799 A AT 0137799A AT 137799 A AT137799 A AT 137799A AT A137799 A ATA137799 A AT A137799A
- Authority
- AT
- Austria
- Prior art keywords
- analog
- factor
- improved activation
- analog factor
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
US09/632,722 US6958322B1 (en) | 1999-08-10 | 2000-08-04 | Factor X analog with an improved ability to be activated |
EP00949465A EP1238065B1 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung |
PCT/EP2000/007631 WO2001010896A2 (en) | 1999-08-10 | 2000-08-07 | Factor x analog with an improved ability to be activated |
DK00949465T DK1238065T3 (da) | 1999-08-10 | 2000-08-07 | Faktor X-analog med forbedret evne til aktivering |
AU62807/00A AU778571B2 (en) | 1999-08-10 | 2000-08-07 | Factor X analog with an improved ability to be activated |
AT00949465T ATE389013T1 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung |
CA002380844A CA2380844A1 (en) | 1999-08-10 | 2000-08-07 | Factor x analog with an improved ability to be activated |
DE60038312T DE60038312T2 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analog mit einer verbesserten fähigkeit, aktiviert zu werden |
ES00949465T ES2302696T3 (es) | 1999-08-10 | 2000-08-07 | Analogo de factor x con mejor capacidad de activacion. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA137799A true ATA137799A (de) | 2002-07-15 |
AT410216B AT410216B (de) | 2003-03-25 |
Family
ID=3512576
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
AT00949465T ATE389013T1 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00949465T ATE389013T1 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung |
Country Status (9)
Country | Link |
---|---|
US (1) | US6958322B1 (de) |
EP (1) | EP1238065B1 (de) |
AT (2) | AT410216B (de) |
AU (1) | AU778571B2 (de) |
CA (1) | CA2380844A1 (de) |
DE (1) | DE60038312T2 (de) |
DK (1) | DK1238065T3 (de) |
ES (1) | ES2302696T3 (de) |
WO (1) | WO2001010896A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030040480A1 (en) * | 2001-07-20 | 2003-02-27 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
DK1781782T3 (da) * | 2004-08-17 | 2010-08-23 | Csl Behring Gmbh | Modificerede vitamin K-afhængige polypeptider |
EP1728798A1 (de) * | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften |
MX336958B (es) | 2005-11-15 | 2016-02-05 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
EP1820508A1 (de) * | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften |
DK2157177T3 (da) * | 2007-05-22 | 2013-06-24 | Baxter Int | Fremgangsmåde til præparativ oprensning af humant furin |
JP5624891B2 (ja) | 2007-12-31 | 2014-11-12 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | ヒト血液凝固因子を発現するトランスジェニック非ヒト動物 |
WO2011017414A2 (en) | 2009-08-04 | 2011-02-10 | Baxter International Inc. | Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a |
CA2850603C (en) | 2011-09-30 | 2021-11-16 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating hemostasis |
CN104755492A (zh) | 2012-07-25 | 2015-07-01 | 催化剂生物科学公司 | 修饰的因子x多肽及其应用 |
MX2015008813A (es) | 2013-01-31 | 2016-03-31 | Pfizer | Composiciones y metodos para contrarrestar la inhibicion del factor xa. |
FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
JP6429885B2 (ja) | 2013-09-24 | 2018-11-28 | ファイザー・インク | 組換えヒト凝固第xa因子タンパク質の不均一集団を含む組成物 |
US10676731B2 (en) | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
FR3050992A1 (fr) * | 2016-05-06 | 2017-11-10 | Lab Francais Du Fractionnement | Mutants du facteur x |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
US4501731A (en) | 1983-06-27 | 1985-02-26 | Tishkoff Garson H | Treatment of disparate bleeding disorders with factor X zymogen |
AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
US5597799A (en) | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
IE914102A1 (en) | 1990-11-26 | 1992-06-03 | Genetics Inst | Expression of pace in host cells and methods of use thereof |
US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
DE4325872C1 (de) | 1993-08-02 | 1994-08-04 | Immuno Ag | Virusinaktivierte Faktor Xa-Präparation |
AT401270B (de) | 1994-09-26 | 1996-07-25 | Immuno Ag | Verfahren zur quantifizierung von genomischer dna |
AT404838B (de) | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
AT405517B (de) | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-deletionsmutanten und analoge davon |
-
1999
- 1999-08-10 AT AT0137799A patent/AT410216B/de not_active IP Right Cessation
-
2000
- 2000-08-04 US US09/632,722 patent/US6958322B1/en not_active Expired - Lifetime
- 2000-08-07 DE DE60038312T patent/DE60038312T2/de not_active Expired - Lifetime
- 2000-08-07 WO PCT/EP2000/007631 patent/WO2001010896A2/en active IP Right Grant
- 2000-08-07 CA CA002380844A patent/CA2380844A1/en not_active Abandoned
- 2000-08-07 EP EP00949465A patent/EP1238065B1/de not_active Expired - Lifetime
- 2000-08-07 ES ES00949465T patent/ES2302696T3/es not_active Expired - Lifetime
- 2000-08-07 AU AU62807/00A patent/AU778571B2/en not_active Ceased
- 2000-08-07 AT AT00949465T patent/ATE389013T1/de active
- 2000-08-07 DK DK00949465T patent/DK1238065T3/da active
Also Published As
Publication number | Publication date |
---|---|
DE60038312T2 (de) | 2009-03-26 |
EP1238065B1 (de) | 2008-03-12 |
WO2001010896A3 (en) | 2002-07-11 |
CA2380844A1 (en) | 2001-02-15 |
DE60038312D1 (de) | 2008-04-24 |
AT410216B (de) | 2003-03-25 |
AU778571B2 (en) | 2004-12-09 |
AU6280700A (en) | 2001-03-05 |
ES2302696T3 (es) | 2008-08-01 |
DK1238065T3 (da) | 2008-07-07 |
ATE389013T1 (de) | 2008-03-15 |
WO2001010896A2 (en) | 2001-02-15 |
EP1238065A2 (de) | 2002-09-11 |
US6958322B1 (en) | 2005-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |