DE60038312D1 - Faktor x-analoge mit verbesserter fähigkeit zur aktivierung - Google Patents

Faktor x-analoge mit verbesserter fähigkeit zur aktivierung

Info

Publication number
DE60038312D1
DE60038312D1 DE60038312T DE60038312T DE60038312D1 DE 60038312 D1 DE60038312 D1 DE 60038312D1 DE 60038312 T DE60038312 T DE 60038312T DE 60038312 T DE60038312 T DE 60038312T DE 60038312 D1 DE60038312 D1 DE 60038312D1
Authority
DE
Germany
Prior art keywords
factor
analogue
improved activation
activation capability
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038312T
Other languages
English (en)
Other versions
DE60038312T2 (de
Inventor
Michele Himmelspach
Uwe Schlokat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter AG
Original Assignee
Baxter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter AG filed Critical Baxter AG
Publication of DE60038312D1 publication Critical patent/DE60038312D1/de
Application granted granted Critical
Publication of DE60038312T2 publication Critical patent/DE60038312T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60038312T 1999-08-10 2000-08-07 Faktor x-analog mit einer verbesserten fähigkeit, aktiviert zu werden Expired - Lifetime DE60038312T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT137799 1999-08-10
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit
PCT/EP2000/007631 WO2001010896A2 (en) 1999-08-10 2000-08-07 Factor x analog with an improved ability to be activated

Publications (2)

Publication Number Publication Date
DE60038312D1 true DE60038312D1 (de) 2008-04-24
DE60038312T2 DE60038312T2 (de) 2009-03-26

Family

ID=3512576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038312T Expired - Lifetime DE60038312T2 (de) 1999-08-10 2000-08-07 Faktor x-analog mit einer verbesserten fähigkeit, aktiviert zu werden

Country Status (9)

Country Link
US (1) US6958322B1 (de)
EP (1) EP1238065B1 (de)
AT (2) AT410216B (de)
AU (1) AU778571B2 (de)
CA (1) CA2380844A1 (de)
DE (1) DE60038312T2 (de)
DK (1) DK1238065T3 (de)
ES (1) ES2302696T3 (de)
WO (1) WO2001010896A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
US8828939B2 (en) 2004-08-17 2014-09-09 Csl Behring Gmbh Modified vitamin K dependent polypeptides
EP1728798A1 (de) * 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (de) 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
AU2008253230B2 (en) * 2007-05-22 2013-07-18 Takeda Pharmaceutical Company Limited Preparative purification process for human furin
US20090235369A1 (en) * 2007-12-31 2009-09-17 Baxter Healthcare S.A. Transgenic Non-Human Animals Expressing Human Blood Clotting Factors and Uses Thereof
JP2013500743A (ja) * 2009-08-04 2013-01-10 バクスター・インターナショナル・インコーポレイテッド Ｆｖｉｉｉおよびｖｗｆがノックアウトされた遺伝子導入マウス−血友病ａモデル
JP6514893B2 (ja) 2011-09-30 2019-05-15 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 止血を調節するための組成物および方法
WO2014018120A1 (en) 2012-07-25 2014-01-30 Catalyst Biosciences, Inc. Modified factor x polypeptides and uses thereof
ES2761730T3 (es) 2013-01-31 2020-05-20 Pfizer Composiciones y procedimientos para contrarrestar la inhibición del factor Xa
FR3001729B1 (fr) 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
AU2014326257B2 (en) 2013-09-24 2017-08-10 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー 宿主細胞でのｐａｃｅの発現およびその使用法
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon

Also Published As

Publication number Publication date
EP1238065A2 (de) 2002-09-11
ATE389013T1 (de) 2008-03-15
WO2001010896A2 (en) 2001-02-15
AT410216B (de) 2003-03-25
CA2380844A1 (en) 2001-02-15
ES2302696T3 (es) 2008-08-01
WO2001010896A3 (en) 2002-07-11
ATA137799A (de) 2002-07-15
US6958322B1 (en) 2005-10-25
AU6280700A (en) 2001-03-05
EP1238065B1 (de) 2008-03-12
AU778571B2 (en) 2004-12-09
DE60038312T2 (de) 2009-03-26
DK1238065T3 (da) 2008-07-07

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