DK2157177T3 - Fremgangsmåde til præparativ oprensning af humant furin - Google Patents

Fremgangsmåde til præparativ oprensning af humant furin

Info

Publication number
DK2157177T3
DK2157177T3 DK09013384.4T DK09013384T DK2157177T3 DK 2157177 T3 DK2157177 T3 DK 2157177T3 DK 09013384 T DK09013384 T DK 09013384T DK 2157177 T3 DK2157177 T3 DK 2157177T3
Authority
DK
Denmark
Prior art keywords
preparative purification
human furin
furin
human
preparative
Prior art date
Application number
DK09013384.4T
Other languages
English (en)
Inventor
Peter Matthiessen
Stefan Romeder-Finger
Peter Turecek
Hans-Peter Schwarz
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Application granted granted Critical
Publication of DK2157177T3 publication Critical patent/DK2157177T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21075—Furin (3.4.21.75)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK09013384.4T 2007-05-22 2008-05-21 Fremgangsmåde til præparativ oprensning af humant furin DK2157177T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93130107P 2007-05-22 2007-05-22
EP08758691A EP2147097A2 (en) 2007-05-22 2008-05-21 PREPARATIVE PURIFICATION METHOD FOR HUMAN FURINE

Publications (1)

Publication Number Publication Date
DK2157177T3 true DK2157177T3 (da) 2013-06-24

Family

ID=39712592

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09013384.4T DK2157177T3 (da) 2007-05-22 2008-05-21 Fremgangsmåde til præparativ oprensning af humant furin

Country Status (14)

Country Link
US (2) US8343748B2 (da)
EP (2) EP2157177B1 (da)
JP (1) JP5485873B2 (da)
KR (1) KR101660533B1 (da)
AU (1) AU2008253230B2 (da)
CA (1) CA2684885C (da)
DK (1) DK2157177T3 (da)
ES (1) ES2416079T3 (da)
HK (1) HK1145188A1 (da)
HR (1) HRP20130560T1 (da)
PL (1) PL2157177T3 (da)
PT (1) PT2157177E (da)
SI (1) SI2157177T1 (da)
WO (1) WO2008141824A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2574677B1 (en) 2007-12-27 2017-09-13 Baxalta GmbH Cell culture processes
ES2735173T3 (es) * 2007-12-31 2019-12-16 Baxalta GmbH Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma
EP2635600B1 (en) 2010-11-05 2017-06-21 F. Hoffmann-La Roche AG Optimized method for antibody capturing by mixed mode chromatography
SG10201604488TA (en) 2011-06-02 2016-07-28 Baxter Int Formulations Of Recombinant Furin
SG10201605397PA (en) 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935815A (en) 1989-10-25 1999-08-10 Katholieke Universiteit Leuven Process for micro biological production of proteins
NL9000917A (nl) 1989-10-25 1991-05-16 Holland Biotechnology Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.
EP0574402B2 (en) 1990-11-26 2012-08-01 Genetics Institute, LLC Expression of pace in host cells and methods of use thereof
AT404838B (de) * 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
ES2735173T3 (es) * 2007-12-31 2019-12-16 Baxalta GmbH Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma

Also Published As

Publication number Publication date
EP2147097A2 (en) 2010-01-27
CA2684885C (en) 2018-09-11
JP5485873B2 (ja) 2014-05-07
JP2010527596A (ja) 2010-08-19
PT2157177E (pt) 2013-04-18
HRP20130560T1 (hr) 2013-07-31
HK1145188A1 (en) 2011-04-08
AU2008253230B2 (en) 2013-07-18
KR101660533B1 (ko) 2016-10-10
PL2157177T3 (pl) 2013-12-31
SI2157177T1 (sl) 2013-05-31
AU2008253230A1 (en) 2008-11-27
EP2157177A1 (en) 2010-02-24
ES2416079T3 (es) 2013-07-30
KR20100022067A (ko) 2010-02-26
US20130115204A1 (en) 2013-05-09
EP2157177B1 (en) 2013-04-10
US8343748B2 (en) 2013-01-01
WO2008141824A3 (en) 2009-03-12
CA2684885A1 (en) 2008-11-27
WO2008141824A2 (en) 2008-11-27
US20090304669A1 (en) 2009-12-10

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