AT396594B - Verfahren und vorrichtung zur herstellung bioaktiver suspensionen - Google Patents
Verfahren und vorrichtung zur herstellung bioaktiver suspensionen Download PDFInfo
- Publication number
- AT396594B AT396594B AT0131488A AT131488A AT396594B AT 396594 B AT396594 B AT 396594B AT 0131488 A AT0131488 A AT 0131488A AT 131488 A AT131488 A AT 131488A AT 396594 B AT396594 B AT 396594B
- Authority
- AT
- Austria
- Prior art keywords
- flow space
- ultrasound
- activators
- sonotrode
- suspension
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 27
- 239000000725 suspension Substances 0.000 title claims description 17
- 230000000975 bioactive effect Effects 0.000 title claims description 8
- 238000002604 ultrasonography Methods 0.000 claims description 24
- 239000012190 activator Substances 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 230000029087 digestion Effects 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000006073 displacement reaction Methods 0.000 claims description 2
- 238000005086 pumping Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000010355 oscillation Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000010297 mechanical methods and process Methods 0.000 description 3
- 230000005226 mechanical processes and functions Effects 0.000 description 3
- 230000002787 reinforcement Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009415 formwork Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
- C12N1/066—Lysis of microorganisms by physical methods
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Mechanical Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Physical Water Treatments (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Disintegrating Or Milling (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD87304852A DD284131A7 (de) | 1987-07-10 | 1987-07-10 | Verfahren und vorrichtung zur herstellung bioaktiver suspensionen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA131488A ATA131488A (de) | 1993-02-15 |
| AT396594B true AT396594B (de) | 1993-10-25 |
Family
ID=5590656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0131488A AT396594B (de) | 1987-07-10 | 1988-05-19 | Verfahren und vorrichtung zur herstellung bioaktiver suspensionen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5074474A (enExample) |
| AT (1) | AT396594B (enExample) |
| CH (1) | CH676802A5 (enExample) |
| DD (1) | DD284131A7 (enExample) |
| DE (1) | DE3821354A1 (enExample) |
| FR (1) | FR2618793B1 (enExample) |
| SE (1) | SE504469C2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4241154C1 (de) * | 1992-12-07 | 1994-03-17 | Lancaster Group Ag | Verfahren zum Aufschluß von Zelldispersionen oder Zellsuspensionen mittels Ultraschallbehandlung zwecks Gewinnung von Zellinhaltsstoffen |
| US6071480A (en) * | 1994-12-22 | 2000-06-06 | Abbott Laboratories | Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator |
| DE19612349A1 (de) * | 1996-03-28 | 1997-12-11 | Alois Dipl Ing Fleig | Apparat und Verfahren zur Behandlung und Herstellung von mehrphasigen Flüssigkeiten, Emulsionen und Suspensionen |
| US6063616A (en) * | 1997-11-04 | 2000-05-16 | Cornell Research Foundation, Inc. | Matrix mill for DNA extraction |
| US6431476B1 (en) * | 1999-12-21 | 2002-08-13 | Cepheid | Apparatus and method for rapid ultrasonic disruption of cells or viruses |
| US20040200909A1 (en) * | 1999-05-28 | 2004-10-14 | Cepheid | Apparatus and method for cell disruption |
| US9073053B2 (en) | 1999-05-28 | 2015-07-07 | Cepheid | Apparatus and method for cell disruption |
| US8815521B2 (en) | 2000-05-30 | 2014-08-26 | Cepheid | Apparatus and method for cell disruption |
| EP1208189B1 (en) | 1999-05-28 | 2004-10-06 | Cepheid | Device and method for analysing liquid samples |
| JP2003533974A (ja) * | 1999-12-23 | 2003-11-18 | ドルニエル メドテック システムズ ゲーエムベーハー | 細胞内に分子を導入する装置 |
| DE19962904A1 (de) * | 1999-12-23 | 2001-08-09 | Dornier Medizintechnik | Verfahren zum Transfer von Molekülen in Zellen und Vorrichtung zur Durchführung des Verfahrens |
| DE10234905B4 (de) * | 2002-07-31 | 2006-12-14 | Dornier Medtech Gmbh | Verfahren zur Verbesserung des akustisch induzierten Molekültransfers |
| US7541166B2 (en) * | 2003-09-19 | 2009-06-02 | Microfluidic Systems, Inc. | Sonication to selectively lyse different cell types |
| US20050070701A1 (en) * | 2003-09-29 | 2005-03-31 | Hochstetler Spencer Erich | Detection of living cells in polymers or pigments |
| US7785868B2 (en) * | 2004-12-02 | 2010-08-31 | Microfluidic Systems, Inc. | Apparatus to automatically lyse a sample |
| US7943352B2 (en) * | 2006-03-29 | 2011-05-17 | Bacoustics, Llc | Apparatus and methods for vaccine development using ultrasound technology |
| DE102007004856A1 (de) * | 2007-01-31 | 2008-08-07 | Universität Wien | Pipetteneinrichtung, Manipulationseinrichtung und Verfahren zur Manipulation biologischer Zellen |
| DE102008021000A1 (de) * | 2008-04-25 | 2009-10-29 | Qiagen Gmbh | Verfahren und Vorrichtung zum Aufschluss von biologischem Material |
| SG159424A1 (en) * | 2008-09-04 | 2010-03-30 | Exland Biotech Inc | Connector and high frequency vibration device having the same |
| US9304066B2 (en) * | 2012-04-11 | 2016-04-05 | Stat-Diagnostica & Innovation S.L. | Fluidically integrated rotary bead beader |
| US9587236B2 (en) | 2013-01-18 | 2017-03-07 | Folim G. Halaka | Continuous sonication for biotechnology applications and biofuel production |
| CA3143378A1 (en) * | 2019-06-25 | 2020-12-30 | Hemex Health, Inc. | External sonication |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985001514A1 (en) * | 1983-09-26 | 1985-04-11 | University Of Iowa Research Foundation | A method of and apparatus for harvesting mammalian cells |
| CH651063A5 (de) * | 1981-05-14 | 1985-08-30 | Elkawi Ag | Verfahren zur gewinnung anaboler, atmungsfoerdernder, niedermolekularer wirkstoffe fuer prophylaktische, therapeutische, zell- und gewebekulturtechnische zwecke. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE166285C (enExample) * | ||||
| DE260162C (enExample) * | ||||
| DE47883C (de) * | W. HOFFACKER in Essen, Ruhr, Varnhorststrafse 13 | Schraubgetriebe zur Umwandlung einer Kehrschub- in eine Umlauf-Bewegung oder umgekehrt | ||
| DE713929C (de) * | 1939-03-31 | 1941-11-18 | Bosch Gmbh Robert | Verfahren und Vorrichtung zur Sichtung von Pulvern |
| US2337569A (en) * | 1939-05-20 | 1943-12-28 | Pietschack Ernst | Method of producing mosaic electrodes |
| US2468515A (en) * | 1944-11-29 | 1949-04-26 | Lancaster Processes Inc | Apparatus for sonic pulverization and dispersion of materials |
| US2591083A (en) * | 1947-03-04 | 1952-04-01 | Doehler Jarvis Corp | Removal of flash, fin, and burr |
| US2738172A (en) * | 1952-11-28 | 1956-03-13 | Nat Dairy Res Lab Inc | Apparatus for treatment of products with ultrasonic energy |
| US2907455A (en) * | 1956-01-17 | 1959-10-06 | Sasaki Noburo | Apparatus for the recovery of fine carbonic fuel particles from slurry by ultrasonicwaves |
| GB938163A (en) * | 1960-09-20 | 1963-10-02 | Boots Pure Drug Co Ltd | Improvements in or relating to particle size reduction or cellular disruption |
| BE712331A (enExample) * | 1968-03-18 | 1968-07-31 | ||
| US3558066A (en) * | 1969-01-21 | 1971-01-26 | Howard Alliger | Ultrasonic extraction of viable antigens from gram positive bacteria |
-
1987
- 1987-07-10 DD DD87304852A patent/DD284131A7/de not_active IP Right Cessation
-
1988
- 1988-05-19 AT AT0131488A patent/AT396594B/de not_active IP Right Cessation
- 1988-06-24 DE DE3821354A patent/DE3821354A1/de not_active Withdrawn
- 1988-07-08 SE SE8802585A patent/SE504469C2/sv not_active IP Right Cessation
- 1988-07-08 FR FR888809298A patent/FR2618793B1/fr not_active Expired - Fee Related
- 1988-07-08 CH CH2609/88A patent/CH676802A5/de not_active IP Right Cessation
- 1988-08-12 US US07/231,736 patent/US5074474A/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH651063A5 (de) * | 1981-05-14 | 1985-08-30 | Elkawi Ag | Verfahren zur gewinnung anaboler, atmungsfoerdernder, niedermolekularer wirkstoffe fuer prophylaktische, therapeutische, zell- und gewebekulturtechnische zwecke. |
| WO1985001514A1 (en) * | 1983-09-26 | 1985-04-11 | University Of Iowa Research Foundation | A method of and apparatus for harvesting mammalian cells |
Also Published As
| Publication number | Publication date |
|---|---|
| US5074474A (en) | 1991-12-24 |
| CH676802A5 (enExample) | 1991-03-15 |
| SE8802585D0 (sv) | 1988-07-08 |
| FR2618793B1 (fr) | 1990-03-23 |
| SE504469C2 (sv) | 1997-02-17 |
| SE8802585L (sv) | 1989-01-11 |
| DE3821354A1 (de) | 1989-07-06 |
| FR2618793A1 (fr) | 1989-02-03 |
| ATA131488A (de) | 1993-02-15 |
| DD284131A7 (de) | 1990-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| ELJ | Ceased due to non-payment of the annual fee |