GB938163A - Improvements in or relating to particle size reduction or cellular disruption - Google Patents

Improvements in or relating to particle size reduction or cellular disruption

Info

Publication number
GB938163A
GB938163A GB3229960A GB3229960A GB938163A GB 938163 A GB938163 A GB 938163A GB 3229960 A GB3229960 A GB 3229960A GB 3229960 A GB3229960 A GB 3229960A GB 938163 A GB938163 A GB 938163A
Authority
GB
United Kingdom
Prior art keywords
inert bodies
liquid
inert
bodies
transducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3229960A
Inventor
Derek John Craik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Priority to GB3229960A priority Critical patent/GB938163A/en
Publication of GB938163A publication Critical patent/GB938163A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/14—Mills in which the charge to be ground is turned over by movements of the container other than by rotating, e.g. by swinging, vibrating, tilting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/18—Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for reducing the particle size of a particulate material comprises subjecting to ultrasonic vibrations a suspension of the material in a chemically inert liquid in the presence of small chemically inert bodies. The suspension may be agitated by means of a hollow stirrer. The inert bodies may be glass beads or stainless steel balls. The inert liquid, which may contain a surface active agent, may be water, a volatile substantially anhydrous liquid e.g. benzene or ether or a solution of an ointment base e.g. petroleum jelly, in a volatile liquid. Apparatus for carrying out the process comprises a combination of an ultrasonic transducer and a vessel containing small inert bodies, the combination being arranged such that the inert bodies may be subjected to ultrasonic vibrations. The transducer may be attached to the base of a vessel containing the inert bodies. In an alternative, an inner vessel may contain the inert bodies and an outer vessel have the transducer attached thereto, the space between the vessels containing a liquid. In a further alternative, a probe with attached ultrasonic transducer may be inserted in a vessel containing the inert bodies. The apparatus may have inlet and outlet means so that it may be used on a continuous basis. Examples are described.ALSO:A process for disrupting cellular material comprises subjecting to ultrasonic vibrations a suspension of the material in a chemically inert liquid in the presence of small chemically inert bodies. The suspension may be agitated by means of a hollow stirrer. The inert bodies may be glass beads or stainless steel balls. The inert liquid, which may contain a surface-active agent, may be water, a volatile substantially anhydrous liquid, e.g. benzene or ether or a solution of an ointment base e.g. petroleum jelly, in a volatile liquid in which case after the process has been completed, the volatile solvent is easily removed to leave a highly dispersed suspension of the fine particles in the ointment base. Apparatus for carrying out the process comprises a combination of an ultrasonic transducer and a vessel containing small inert bodies, the combination being arranged such that the inert bodies may be subjected to ultrasonic vibrations. The transducer may be attached to the base of a vessel containing the inert bodies. In an alternative, an inner vessel may contain the inert bodies and an outer vessel have the transducer attached thereto, the space between the vessels containing a liquid. In a further alternative, a probe with attached ultrasonic transducer may be inserted in a vessel containing the inert bodies. The apparatus may have inlet and outlet means so that it may be used on a continuous basis. Examples are described of the subdivision of procaine penicillin, a steroid, staphylococcus aureus, yeast and sulphur.
GB3229960A 1960-09-20 1960-09-20 Improvements in or relating to particle size reduction or cellular disruption Expired GB938163A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3229960A GB938163A (en) 1960-09-20 1960-09-20 Improvements in or relating to particle size reduction or cellular disruption

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3229960A GB938163A (en) 1960-09-20 1960-09-20 Improvements in or relating to particle size reduction or cellular disruption

Publications (1)

Publication Number Publication Date
GB938163A true GB938163A (en) 1963-10-02

Family

ID=10336446

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3229960A Expired GB938163A (en) 1960-09-20 1960-09-20 Improvements in or relating to particle size reduction or cellular disruption

Country Status (1)

Country Link
GB (1) GB938163A (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62236478A (en) * 1986-03-20 1987-10-16 ジエン−プロ−ブ・インコ−ポレイテツド Separation of rna and dna from cell
FR2618793A1 (en) * 1987-07-10 1989-02-03 Berlin Kosmetik Veb METHOD AND DEVICE FOR OBTAINING BIO-ACTIVE SUSPENSIONS
EP0796917A2 (en) * 1996-03-12 1997-09-24 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
EP0897989A2 (en) * 1997-08-15 1999-02-24 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
WO1999058637A2 (en) * 1998-05-07 1999-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device and method for targeted exposure of a biological sample to sound waves
US6071480A (en) * 1994-12-22 2000-06-06 Abbott Laboratories Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator
FR2791697A1 (en) * 1999-04-01 2000-10-06 Biomerieux Sa Apparatus for ultrasonic cell lysis, useful for recovering nucleic acids from bacteria and yeast, in which the probe has an active surface that matches the shape of the sample vessel
WO2000073413A2 (en) * 1999-05-28 2000-12-07 Cepheid Apparatus and method for cell disruption
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US6440725B1 (en) 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
WO2009149298A1 (en) 2008-06-05 2009-12-10 Sonoash Llc Upgraded combustion ash and its method of production
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US8268603B2 (en) 1999-05-28 2012-09-18 Cepheid Apparatus and method for cell disruption
US8441629B2 (en) 2009-04-15 2013-05-14 Biocartis Sa Optical detection system for monitoring rtPCR reaction
US8512637B2 (en) 2009-05-06 2013-08-20 Biocartis Sa Device for cutting a sample carrier
US8641971B2 (en) 2009-04-14 2014-02-04 Biocartis Sa HIFU induced cavitation with reduced power threshold
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US9079182B2 (en) 2009-04-15 2015-07-14 Biocartis Nv Protection of bioanalytical sample chambers

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62236478A (en) * 1986-03-20 1987-10-16 ジエン−プロ−ブ・インコ−ポレイテツド Separation of rna and dna from cell
EP0288618A1 (en) * 1986-03-20 1988-11-02 Gen-Probe Incorporated Method for releasing RNA and DNA from cells
JPH0528599B2 (en) * 1986-03-20 1993-04-26 Jen Puroobu Inc
FR2618793A1 (en) * 1987-07-10 1989-02-03 Berlin Kosmetik Veb METHOD AND DEVICE FOR OBTAINING BIO-ACTIVE SUSPENSIONS
US6071480A (en) * 1994-12-22 2000-06-06 Abbott Laboratories Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator
EP0796917A3 (en) * 1996-03-12 1998-11-25 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
EP0796917A2 (en) * 1996-03-12 1997-09-24 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
EP0897989A2 (en) * 1997-08-15 1999-02-24 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
EP0897989A3 (en) * 1997-08-15 2002-06-26 Becton, Dickinson and Company Vehicle for delivery of particles to a sample
US6440725B1 (en) 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
WO1999058637A2 (en) * 1998-05-07 1999-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device and method for targeted exposure of a biological sample to sound waves
WO1999058637A3 (en) * 1998-05-07 2000-01-27 Fraunhofer Ges Forschung Device and method for targeted exposure of a biological sample to sound waves
US6699711B1 (en) * 1998-05-07 2004-03-02 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Device and method for selective exposure of a biological sample to sound waves
US6987018B2 (en) 1998-12-24 2006-01-17 Cepheid Container for holding cells or viruses for disruption
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US8247176B2 (en) 1998-12-24 2012-08-21 Cepheid Method for separating an analyte from a sample
US6887693B2 (en) 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
US8592157B2 (en) 1998-12-24 2013-11-26 Cepheid Method for separating an analyte from a sample
EP1466966A1 (en) * 1999-04-01 2004-10-13 Biomerieux S.A. Apparatus and process of lysis by biological ultrasounds of cells
WO2000060049A1 (en) * 1999-04-01 2000-10-12 Biomerieux S.A. Method and apparatus for ultrasonic lysis of biological cells
FR2791697A1 (en) * 1999-04-01 2000-10-06 Biomerieux Sa Apparatus for ultrasonic cell lysis, useful for recovering nucleic acids from bacteria and yeast, in which the probe has an active surface that matches the shape of the sample vessel
US6686195B1 (en) 1999-04-01 2004-02-03 Biomerieux S.A. Method and apparatus for ultrasonic lysis of biological cells
US6783736B1 (en) 1999-05-28 2004-08-31 Cepheid Cartridge for analyzing a fluid sample
WO2000073413A3 (en) * 1999-05-28 2001-01-25 Cepheid Apparatus and method for cell disruption
US8709363B2 (en) 1999-05-28 2014-04-29 Cepheid Cartridge for conducting a chemical reaction
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US6881541B2 (en) 1999-05-28 2005-04-19 Cepheid Method for analyzing a fluid sample
US6391541B1 (en) 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample
WO2000073412A3 (en) * 1999-05-28 2002-03-21 Cepheid Apparatus and method for analyzing a fluid sample
US9943848B2 (en) 1999-05-28 2018-04-17 Cepheid Apparatus and method for cell disruption
WO2000073413A2 (en) * 1999-05-28 2000-12-07 Cepheid Apparatus and method for cell disruption
US8168442B2 (en) 1999-05-28 2012-05-01 Cepheid Cartridge for conducting a chemical reaction
WO2000073412A2 (en) * 1999-05-28 2000-12-07 Cepheid Apparatus and method for analyzing a fluid sample
US8268603B2 (en) 1999-05-28 2012-09-18 Cepheid Apparatus and method for cell disruption
US9789481B2 (en) 1999-05-28 2017-10-17 Cepheid Device for extracting nucleic acid from a sample
US9322052B2 (en) 1999-05-28 2016-04-26 Cepheid Cartridge for conducting a chemical reaction
US8580559B2 (en) 1999-05-28 2013-11-12 Cepheid Device for extracting nucleic acid from a sample
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US6878540B2 (en) 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
EP2303461A4 (en) * 2008-06-05 2017-04-19 Provectus Engineered Materiels Ltd. Upgraded combustion ash and its method of production
WO2009149298A1 (en) 2008-06-05 2009-12-10 Sonoash Llc Upgraded combustion ash and its method of production
US8986612B2 (en) 2009-04-14 2015-03-24 Biocartis Nv HIFU induced cavitation with reduced power threshold
US8641971B2 (en) 2009-04-14 2014-02-04 Biocartis Sa HIFU induced cavitation with reduced power threshold
US9097626B2 (en) 2009-04-14 2015-08-04 Biocartis Nv HIFU induced cavitation with reduced power threshold
US9079182B2 (en) 2009-04-15 2015-07-14 Biocartis Nv Protection of bioanalytical sample chambers
US8441629B2 (en) 2009-04-15 2013-05-14 Biocartis Sa Optical detection system for monitoring rtPCR reaction
US8512637B2 (en) 2009-05-06 2013-08-20 Biocartis Sa Device for cutting a sample carrier

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