AT345977B - Verfahren zur herstellung eines stabilen antibiotischen praeparates - Google Patents

Verfahren zur herstellung eines stabilen antibiotischen praeparates

Info

Publication number
AT345977B
AT345977B AT971776A AT971776A AT345977B AT 345977 B AT345977 B AT 345977B AT 971776 A AT971776 A AT 971776A AT 971776 A AT971776 A AT 971776A AT 345977 B AT345977 B AT 345977B
Authority
AT
Austria
Prior art keywords
preparate
producing
stable antibiotic
antibiotic
stable
Prior art date
Application number
AT971776A
Other languages
German (de)
English (en)
Other versions
ATA971776A (de
Inventor
William Wellesley Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ATA971776A publication Critical patent/ATA971776A/de
Application granted granted Critical
Publication of AT345977B publication Critical patent/AT345977B/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • A61K31/787Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79Polymers of vinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)
AT971776A 1976-01-02 1976-12-28 Verfahren zur herstellung eines stabilen antibiotischen praeparates AT345977B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/646,295 US4018889A (en) 1976-01-02 1976-01-02 Oxytetracycline compositions
CA268,177A CA1075603A (en) 1976-01-02 1976-12-17 Stable solutions of doxycycline in aqueous 2-pyrrolidone
KR7700012A KR810000900B1 (ko) 1976-01-02 1977-01-06 항생물질 조성제의 안정화 방법

Publications (2)

Publication Number Publication Date
ATA971776A ATA971776A (de) 1978-02-15
AT345977B true AT345977B (de) 1978-10-10

Family

ID=27164830

Family Applications (1)

Application Number Title Priority Date Filing Date
AT971776A AT345977B (de) 1976-01-02 1976-12-28 Verfahren zur herstellung eines stabilen antibiotischen praeparates

Country Status (29)

Country Link
US (3) US4018889A (show.php)
JP (1) JPS5290616A (show.php)
KR (1) KR810000900B1 (show.php)
AR (1) AR209242A1 (show.php)
AT (1) AT345977B (show.php)
BE (1) BE849885A (show.php)
BG (1) BG36493A3 (show.php)
CA (2) CA1075603A (show.php)
CH (1) CH616080A5 (show.php)
CS (1) CS205030B2 (show.php)
DD (1) DD129997A5 (show.php)
DE (1) DE2659152C2 (show.php)
DK (1) DK145753C (show.php)
EG (1) EG12291A (show.php)
FI (1) FI56116C (show.php)
FR (1) FR2336937A1 (show.php)
GB (1) GB1520197A (show.php)
GR (1) GR65305B (show.php)
HK (1) HK30181A (show.php)
IE (1) IE44767B1 (show.php)
IN (1) IN145845B (show.php)
KE (1) KE3166A (show.php)
LU (1) LU76493A1 (show.php)
NL (1) NL166620C (show.php)
OA (1) OA05524A (show.php)
PT (1) PT66017B (show.php)
SE (1) SE435997B (show.php)
SU (1) SU1309901A3 (show.php)
ZA (1) ZA767689B (show.php)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
DE2963584D1 (en) * 1978-08-01 1982-10-21 Ciba Geigy Ag Stable, liquid pharmaceutical formulation, its preparation and use
EP0012496B1 (en) * 1978-12-08 1983-07-20 Beecham Group Plc A process for the preparation of a solid sodium amoxycillin and aqueous solutions thereof
US4259331A (en) * 1979-04-16 1981-03-31 Pfizer Inc. Oxytetracycline compositions
EP0021847B1 (en) * 1979-07-02 1983-07-20 Pfizer Inc. Long acting sulfonamide injectable compositions
DE3063763D1 (en) * 1979-07-05 1983-07-21 Pfizer Sulfonamide solutions
US4303643A (en) * 1979-07-05 1981-12-01 Pfizer Inc. Sulfonamide compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
CA1163197A (en) * 1980-04-10 1984-03-06 Herman Horn Injectable oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4374826A (en) * 1980-07-21 1983-02-22 Pfizer Inc. Sulfonamide compositions
NL178941C (nl) * 1982-06-15 1986-06-16 Aesculaap Bv Werkwijze voor de bereiding van een waterig oxytetracyclinepreparaat.
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
HU194493B (en) * 1985-11-27 1988-02-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing primycin-containing colloidal basic gel and compositions comprising the same
FR2608044B1 (fr) * 1986-12-10 1992-09-11 Sogeval Composition antibiotique aqueuse a usage veterinaire
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0626171A1 (de) * 1993-05-26 1994-11-30 Winfried Dörnhöfer Injektionslösung für die intravenöse oder intramuskuläre Verabreichung an Tiere
ES2130069B1 (es) * 1997-04-10 2000-03-01 Basf Labiana S A Preparacion farmaceutica con liberacion retardada del producto activo.
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CN102336680A (zh) 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
AU2001228454A1 (en) * 2000-01-13 2001-07-24 Merck Patent G.M.B.H Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary
US6833365B2 (en) 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
CN1452611A (zh) 2000-07-07 2003-10-29 塔夫茨大学信托人 13-取代甲烯土霉素化合物
CZ2003343A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE336481T1 (de) * 2000-07-07 2006-09-15 Tufts College 9-substituierte minocyclinverbindungen
AU2001271556A1 (en) 2000-07-07 2002-01-21 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
RU2178698C1 (ru) * 2000-11-28 2002-01-27 Закрытое Акционерное Общество "Нита-Фарм" Способ получения композиции магниевого комплекса окситетрациклина пролонгированного действия
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
IL157860A0 (en) 2001-03-13 2004-03-28 Paratek Pharm Innc 7,9-substituted tetracycline compounds
US6841546B2 (en) 2001-03-14 2005-01-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
JP2005504722A (ja) 2001-03-14 2005-02-17 パラテック ファーマシューティカルズ インコーポレイテッド 相乗的抗真菌薬剤としての置換テトラサイクリン化合物
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
ES2338994T3 (es) 2001-04-24 2010-05-14 Paratek Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida para el tratamiento de la malaria.
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
AU2003235759A1 (en) * 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
AU2003220123B2 (en) 2002-03-08 2009-05-07 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
EP2345637A3 (en) 2002-07-12 2012-02-15 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
AU2003287218C1 (en) 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
AU2003300379A1 (en) * 2002-12-27 2004-07-29 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collagen and MMPI
AU2004259661B2 (en) 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EA201100956A1 (ru) 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
WO2005011707A1 (en) * 2003-07-25 2005-02-10 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
JP2008518025A (ja) * 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド 4−アミノテトラサイクリンおよびその使用の方法
CA2585248A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
SG158869A1 (en) * 2005-01-21 2010-02-26 Warner Chilcott Co Llc A tetracycline metal complex in a solid dosage form
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド 10−置換テトラサイクリンおよびその使用方法
US9078811B2 (en) * 2006-01-24 2015-07-14 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
CA2649075A1 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Tigeycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
CA2652346A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
CA2673486C (en) 2006-12-21 2015-09-08 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP2452935A3 (en) 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
AU2008239606A1 (en) * 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
AU2008246119A1 (en) 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
WO2009009042A1 (en) 2007-07-06 2009-01-15 Paratek Pharmaceuticals, Inc. Methods for synthesizing substituted tetracycline compounds
AU2009220171A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
CA2721399A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TW202436282A (zh) * 2008-05-19 2024-09-16 美商Prtk Spv2公司 四環素化合物之甲苯磺酸鹽及同素異形體
MX2011002780A (es) * 2008-09-19 2011-04-27 Paratek Pharm Innc Compuestos de tetraciclina para el tratamiento de artritis reumatoide y metodos relacionados de tratamiento.
EP2416799B1 (en) 2009-04-10 2017-11-01 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
PT2568987T (pt) 2010-05-12 2017-02-03 Rempex Pharmaceuticals Inc Composições de tetraciclina
TR201911086T4 (tr) 2011-05-12 2019-08-21 Allergan Pharmaceuticals Int Ltd (4s,4as,5ar,12as)-4- Dimetilamino-3,10,12,12a-tetrahidroksi-7-[(metoksi(metil)amino)-metil]-1,11-diokso-1,4,4a,5,5a,6,11,12a-oktahidro-naftasen-2-karboksilik asit amidin kristalli tuzları ve bunların kullanım yöntemleri.
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
WO2015021387A2 (en) * 2013-08-09 2015-02-12 Britt George N Formulations for control and prevention of periodontal and perimplant diseases and other diseases and conditions of the mouth, and supra and sub-gingival delivery methods and systems for such formulations
CN103536530A (zh) * 2013-10-30 2014-01-29 王玉万 盐酸多西环素长效注射剂及制备方法
US9918998B2 (en) 2015-03-23 2018-03-20 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
CN104721133B (zh) * 2015-04-14 2018-05-18 四川美嘉龙生物科技有限公司 一种土霉素制剂及制备方法
MY200446A (en) 2016-11-01 2023-12-26 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
ES2962380T3 (es) 2017-07-21 2024-03-18 Almirall Llc Sareciclina para el tratamiento de lesiones de acné no inflamatorias
AU2018374490B2 (en) 2017-11-28 2024-05-16 New Matterhorn, Llc Method for producing trehalose employing a trehalose phosphorylase variant
US11426351B2 (en) 2019-12-26 2022-08-30 Sunstar Inc. Process for producing a pharmaceutical composition containing micro particles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB805026A (en) * 1956-03-02 1958-11-26 Konink Nl Gisten Spiritusfabri Process for enhancing the solubility of medicines in water
GB802111A (en) * 1956-09-25 1958-10-01 Irwin Irville Lubowe Improved non-toxic pesticidal compositions
US2990331A (en) * 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
DE1091287B (de) * 1957-04-09 1960-10-20 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung stabiler, waessriger Loesungen von Tyrothricin und Subtilin
US2980584A (en) * 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2987437A (en) * 1958-03-06 1961-06-06 Gen Aniline & Film Corp Nematocidal composition
US3062717A (en) * 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
NL6607516A (show.php) * 1966-05-31 1967-12-01
US3957972A (en) * 1966-05-31 1976-05-18 Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. Stable solutions of oxytetracycline suitable for parenteral and peroral administration and process of preparation
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
DK138974B (da) * 1974-02-19 1978-11-27 Ciba Geigy Ag Fremgangsmåde til fremstilling af vandige oxytetracyclinopløsninger til parenteral, peroral og lokal anvendelse.
US3969516A (en) * 1974-12-19 1976-07-13 Nelson Research & Development Company Composition and method for treatment of acne
US3932653A (en) * 1974-12-19 1976-01-13 Nelson Research & Development Co. Composition and method for topical administration of griseofulvin
US3957994A (en) * 1974-12-19 1976-05-18 Nelson Research & Development Company Topical anti-inflammatory composition and method of use
GB1538903A (en) 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent

Also Published As

Publication number Publication date
AR209242A1 (es) 1977-03-31
JPS565368B2 (show.php) 1981-02-04
HK30181A (en) 1981-07-10
US4018889A (en) 1977-04-19
GB1520197A (en) 1978-08-02
SU1309901A3 (ru) 1987-05-07
JPS5290616A (en) 1977-07-30
SE7613959L (sv) 1977-07-03
NL7614470A (nl) 1977-07-05
FR2336937A1 (fr) 1977-07-29
DE2659152A1 (de) 1977-07-14
SE435997B (sv) 1984-11-05
AU2057176A (en) 1978-09-28
LU76493A1 (show.php) 1977-07-05
DE2659152C2 (de) 1984-04-05
ATA971776A (de) 1978-02-15
US4081528A (en) 1978-03-28
DK145753C (da) 1983-08-08
NL166620C (nl) 1981-09-15
IN145845B (show.php) 1979-01-06
FI763716A7 (show.php) 1977-07-03
US4086332A (en) 1978-04-25
DD129997A5 (de) 1978-03-01
CS205030B2 (en) 1981-04-30
CA1075603A (en) 1980-04-15
FI56116B (fi) 1979-08-31
CH616080A5 (show.php) 1980-03-14
BG36493A3 (en) 1984-11-15
OA05524A (fr) 1981-04-30
FI56116C (fi) 1979-12-10
BE849885A (fr) 1977-06-28
PT66017A (en) 1977-01-01
DK145753B (da) 1983-02-21
CA1072012A (en) 1980-02-19
KR810000900B1 (ko) 1981-08-19
PT66017B (en) 1978-06-19
FR2336937B1 (show.php) 1980-06-27
IE44767L (en) 1977-07-02
ZA767689B (en) 1977-12-28
GR65305B (en) 1980-08-01
EG12291A (en) 1978-09-30
DK584676A (da) 1977-07-03
IE44767B1 (en) 1982-03-24
NL166620B (nl) 1981-04-15
KE3166A (en) 1981-11-06

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