AT218177B - Process for the production of narcotic injection preparations - Google Patents

Process for the production of narcotic injection preparations

Info

Publication number
AT218177B
AT218177B AT81860A AT81860A AT218177B AT 218177 B AT218177 B AT 218177B AT 81860 A AT81860 A AT 81860A AT 81860 A AT81860 A AT 81860A AT 218177 B AT218177 B AT 218177B
Authority
AT
Austria
Prior art keywords
production
injection preparations
preparations
narcotic injection
narcotic
Prior art date
Application number
AT81860A
Other languages
German (de)
Original Assignee
Geigy Ag J R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geigy Ag J R filed Critical Geigy Ag J R
Application granted granted Critical
Publication of AT218177B publication Critical patent/AT218177B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Herstellung von narkotisch wirkenden
Injektionspräparaten 
Die vorliegende Erfindung betrifft neue narkotisch wirksame Emulsionen, ihre Herstellung sowie ihre Anwendung. 



   Substituierte Phenoxyessigsäure-dialkylamide der allgemeinen Formel 
 EMI1.1 
 
 EMI1.2 
 

 <Desc/Clms Page number 2> 

 
 EMI2.1 




   <Desc / Clms Page number 1>
 



  Process for the production of narcotic agents
Injection preparations
The present invention relates to new narcotically active emulsions, their preparation and their use.



   Substituted phenoxyacetic acid dialkylamides of the general formula
 EMI1.1
 
 EMI1.2
 

 <Desc / Clms Page number 2>

 
 EMI2.1

Claims (1)

oder a-HydroxyalkylrestPATENTANSPRUCH : Verfahren zur Herstellung von narkotisch wirkenden Injektionspräparaten, bestehend aus stabilen und hitzesterilisierbaren Emulsionen, dadurch gekennzeichnet, dass 2-10% einer Verbindung der allgemeinen Formel EMI3.1 EMI3.2 cithinpräparates in 96-80% Wasser emulgiert werden, wobei ein Teil des Soja-Leeithinpräparates durch einen zusätzlichen Gehalt an partiellen Glyceriden höherer Fettsäuren und/oder deren Polyoxyäthylenderivaten ersetzt sein kann sowie gegebenenfalls Glukose zur Erzielung der Blut-Isotonie zugefügt wird. or a-hydroxyalkyl radical PATENT CLAIM: Process for the production of narcotic injection preparations, consisting of stable and heat-sterilizable emulsions, characterized in that 2-10% of a compound of the general formula EMI3.1 EMI3.2 cithin preparations are emulsified in 96-80% water, with part of the soy-leeithin preparation being replaced by an additional content of partial glycerides of higher fatty acids and / or their polyoxyethylene derivatives and, if necessary, glucose is added to achieve blood isotonicity.
AT81860A 1960-01-27 1960-02-03 Process for the production of narcotic injection preparations AT218177B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH218177X 1960-01-27

Publications (1)

Publication Number Publication Date
AT218177B true AT218177B (en) 1961-11-10

Family

ID=4450484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81860A AT218177B (en) 1960-01-27 1960-02-03 Process for the production of narcotic injection preparations

Country Status (1)

Country Link
AT (1) AT218177B (en)

Similar Documents

Publication Publication Date Title
CH414063A (en) X-ray contrast media
DE1617320A1 (en) Cosmetic skin care products
AT218177B (en) Process for the production of narcotic injection preparations
DE750501C (en) Additive for detergents
DE713917C (en) Process for the production of medicinal ointments from therapeutically effective dyes and dye decoctions
DE662035C (en) Process for the production of laxatives
AT142025B (en) Process for the preparation of a durable combination of an anesthetic with a vasoconstrictor and a so-called buffer substance.
AT211483B (en) Preparations for shaping hair in an acidic medium
DE637942C (en) Process for the production of a skin and wound ointment
AT148785B (en) Process for the preparation of stable solutions of substances with anesthetic effect.
DE657129C (en) Process for the production of solutions or extracts from bacteria, pollen or other plant cells
DE468604C (en) Gelatine for light-sensitive silver salt emulsions and processes for processing ordinary gelatine
AT164264B (en) Process for the manufacture of a liquid medicinal product for dermatological purposes
DE734509C (en) Process for mercerizing
AT85032B (en) Process for the preparation of an antiluetic.
AT208857B (en) Process for the preparation of the new 2,4&#39;-isopentyloxy-phenylimino-3,4 &#34;-isopentyloxy-phenyl-thiazolidine
DE368109C (en) Process for the preparation of a formaldehyde-hydrated, transparent, antiseptic soap having a soap-like texture
AT219202B (en) Process for stabilizing the active oxygen in organic ozone compounds
AT211306B (en) Process for the preparation of the new 1- (4-chlorophenyl) -3- (5-nitro-2-furyl) -2-propenone- (1)
CH400179A (en) Process for the preparation of triamine acid addition salts
AT215082B (en) Corneal emollients
AT290200B (en) Preservatives for vegetable and animal preparations
AT238195B (en) Process for the production of new triazolidines
DE672804C (en) Process for the production of oily suspensions of the anterior pituitary lobe hormone
DE719366C (en) Process for the preparation of salts of the N-acyl derivatives of p-aminophenylstibic acid