AR240827A2 - Procedimiento de preparacion de una cefalosporina y compuesto exclu-sivamente como intermediario para el procedimiento. - Google Patents

Procedimiento de preparacion de una cefalosporina y compuesto exclu-sivamente como intermediario para el procedimiento.

Info

Publication number
AR240827A2
AR240827A2 AR29821584A AR29821584A AR240827A2 AR 240827 A2 AR240827 A2 AR 240827A2 AR 29821584 A AR29821584 A AR 29821584A AR 29821584 A AR29821584 A AR 29821584A AR 240827 A2 AR240827 A2 AR 240827A2
Authority
AR
Argentina
Prior art keywords
ilo
alkyl
oxo
radical
radical alkyl
Prior art date
Application number
AR29821584A
Other languages
English (en)
Other versions
AR240827A1 (es
Original Assignee
Toyama Chemical Co Tld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59104759A external-priority patent/JPS60248691A/ja
Priority claimed from JP59192635A external-priority patent/JPS6172788A/ja
Application filed by Toyama Chemical Co Tld filed Critical Toyama Chemical Co Tld
Application granted granted Critical
Publication of AR240827A2 publication Critical patent/AR240827A2/es
Publication of AR240827A1 publication Critical patent/AR240827A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UNA CEFALOSPORINA DE LA FORMULA GENERAL (1) O SU SAL, EN DONDE R2 REPRESENTA UN RADICAL ALQUILO, R3 REPRESENTA UN ATOMO DE H O UN ALQUILO, FTALIDILO, DIFENILMETILO, ALCANOILOXIMETILO, -CHOCO-[ALQUILO O FENILO! O -CHOCO-ALQUILO, R4 ES UN RADICAL 1,2,6-TIADIAZIN-1,1-DIOXIDO-2-ILO, ISOTIAZOLIDIN-1, 1-DIOXIDO-2-ILO, 2,3-DIOXO-1,2,3,4-TETRAHIDROPIRAZIN-1-ILO, 3,6-DIOXO-1,2,3,6-TETRAHIDROPIRIDAZIN-1-ILO, 6-OXO-1, 6-DIHIDROPIRIDAZIN-1-ILO, 2-OXO-1,2-DIHIDROPIRAZIN-1-ILO, 6-OXO-1,6-DIHIDROPIRIMIDIN-1-ILO,2-OXO-1, 2-DIHIDROPIRIMIDIN-1-ILO, 1,2,4-TRIAZOL-1-ILO O 1,2,3,4-TETRAZOL-2-ILO, OPCIONALMENTE SUSTITUIDO CON AL MENOS UN SUSTITUYENTE ELEGIDO ENTRE UN ATOMO DE HALOGENO, UN RADICAL ALQUILO Y UN RADICAL ALQUIL-TIO, UN COMPUESTO DE LA FORMULA (II), EN DONDE R1 REPRESENTA UN ATOMO DE H O UN RADICAL ALQUILO, FENILO, P-NITROFENILO O PIRIDIN-4-ILO Y R4 TIENE VALORES YA DEFINIDOS, SE HACE REACCIONAR CON UN COMPUESTO DE LA FORMULA (III), EN DONDE R3A ES UN RADICAL ALQUILO, FTALIDILO, DIFENILMETILO, ALCANOIL-OXI-METILO, -CHOCO-[ALQUILO O FENILO! Y R4 TIENE LOS SIGNIFICADOS ARRIBA DEFINIDOS EN PRESENCIA DE TRIFLUORURO DE BORO O UNCOMPUESTO COMPLEJO Y EN CASO DESEADO SE SEPARA EL GRUPO DIFENILMETILO REPRESENTATIVO DE R3 EN PRESENCIA DE ANISOL Y ACIDO TRIFLUOROACETICO.
AR298215A 1984-05-25 1984-10-09 Procedimiento de preparacion de una cefalosporina y compuesto exclu-sivamente como intermediario para el procedimiento. AR240827A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59104759A JPS60248691A (ja) 1984-05-25 1984-05-25 セファロスポリン類の新規製造法
JP59192635A JPS6172788A (ja) 1984-09-17 1984-09-17 セフアロスポリン類の新規製造法

Publications (2)

Publication Number Publication Date
AR240827A2 true AR240827A2 (es) 1991-02-28
AR240827A1 AR240827A1 (es) 1991-02-28

Family

ID=26445155

Family Applications (1)

Application Number Title Priority Date Filing Date
AR298215A AR240827A1 (es) 1984-05-25 1984-10-09 Procedimiento de preparacion de una cefalosporina y compuesto exclu-sivamente como intermediario para el procedimiento.

Country Status (27)

Country Link
US (2) US4656287A (es)
KR (1) KR870001251B1 (es)
AR (1) AR240827A1 (es)
AT (1) AT386412B (es)
BE (1) BE900770A (es)
CA (1) CA1225391A (es)
CH (1) CH664965A5 (es)
CS (1) CS247185B2 (es)
DE (1) DE3436603A1 (es)
DK (1) DK482184A (es)
EG (1) EG16588A (es)
ES (1) ES8604181A1 (es)
FI (1) FI80886C (es)
FR (1) FR2564840B1 (es)
GB (1) GB2161476B (es)
HU (1) HU192469B (es)
IL (1) IL73234A (es)
IT (1) IT1199207B (es)
LU (1) LU85909A1 (es)
NL (1) NL8403069A (es)
NO (1) NO164772C (es)
NZ (2) NZ209725A (es)
PH (2) PH20486A (es)
PL (1) PL144987B1 (es)
PT (1) PT79331B (es)
RO (2) RO92777B (es)
SE (2) SE463973B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
JPH0717622B2 (ja) * 1986-06-05 1995-03-01 エーザイ株式会社 チアジアゾリルアセトアミド誘導体
US5066799A (en) * 1986-07-28 1991-11-19 American Cyanamid Company Intermediates for the preparation of aminothiazoloximino cephalosporins
RU2420525C2 (ru) * 2005-07-11 2011-06-10 Мицубиси Танабе Фарма Корпорейшн Производные оксимов и их получение
US11589754B2 (en) 2009-05-20 2023-02-28 Sotera Wireless, Inc. Blood pressure-monitoring system with alarm/alert system that accounts for patient motion
US9492092B2 (en) * 2009-05-20 2016-11-15 Sotera Wireless, Inc. Method for continuously monitoring a patient using a body-worn device and associated system for alarms/alerts
US9596999B2 (en) 2009-06-17 2017-03-21 Sotera Wireless, Inc. Body-worn pulse oximeter
CN102093266B (zh) * 2011-01-21 2013-07-24 蚌埠丰原医药科技发展有限公司 一种制备o-甲苯磺酰基-2-氨甲酰基-2-甲氧亚氨基乙酰胺肟的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39062A (en) 1971-04-15 1975-02-10 Toyama Chemical Co Ltd A process for producing an antibiotic substance of the penicillin and cephalosporin series
JPS5533719B2 (es) 1973-01-13 1980-09-02
US4121026A (en) * 1973-03-23 1978-10-17 Petrolite Corporation Copolymers of alpha-olefins and maleic anhydride reacted with amines in the presence of Lewis acids
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4299829A (en) * 1976-03-12 1981-11-10 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
FR2461712A1 (fr) * 1979-07-23 1981-02-06 Hoechst Ag Procede de preparation de derives de cepheme
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (en) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
DK521883A (da) * 1982-11-17 1984-05-18 Toyama Chemical Co Ltd Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor
JPH10772A (ja) * 1996-06-14 1998-01-06 Minolta Co Ltd インクジェット記録ヘッド用圧電部材の駆動方法および圧電部材

Also Published As

Publication number Publication date
CS247185B2 (en) 1986-12-18
SE502208C2 (sv) 1995-09-18
NO844036L (no) 1985-11-26
KR870001251B1 (ko) 1987-06-29
BE900770A (fr) 1985-04-09
AT386412B (de) 1988-08-25
GB8424417D0 (en) 1984-10-31
CH664965A5 (de) 1988-04-15
ES546296A0 (es) 1986-01-16
US4736026A (en) 1988-04-05
DE3436603A1 (de) 1985-12-05
ES8604181A1 (es) 1986-01-16
IL73234A (en) 1988-11-15
IT8448974A0 (it) 1984-10-08
KR850008173A (ko) 1985-12-13
DK482184D0 (da) 1984-10-09
FI80886C (fi) 1990-08-10
AR240827A1 (es) 1991-02-28
RO89363A (ro) 1986-05-30
US4656287A (en) 1987-04-07
IL73234A0 (en) 1985-01-31
NO164772B (no) 1990-08-06
PT79331A (en) 1984-11-01
RO92777A (ro) 1987-11-30
PL249955A1 (en) 1985-12-17
NZ209725A (en) 1987-05-29
SE463973B (sv) 1991-02-18
CA1225391A (en) 1987-08-11
PH20486A (en) 1987-01-16
GB2161476B (en) 1988-01-27
NO164772C (no) 1990-11-14
IT8448974A1 (it) 1986-04-08
SE8804101D0 (es) 1988-11-14
FR2564840A1 (fr) 1985-11-29
SE8405043D0 (sv) 1984-10-09
HUT37621A (en) 1986-01-23
FI80886B (fi) 1990-04-30
SE8804101L (sv) 1988-11-14
PL144987B1 (en) 1988-07-30
GB2161476A (en) 1986-01-15
FR2564840B1 (fr) 1986-12-05
DK482184A (da) 1985-11-26
EG16588A (en) 1988-10-31
RO92777B (ro) 1987-12-01
SE8405043L (sv) 1985-11-26
IT1199207B (it) 1988-12-30
PH21264A (en) 1987-09-28
HU192469B (en) 1987-06-29
FI843959L (fi) 1985-11-26
NZ219361A (en) 1987-05-29
NL8403069A (nl) 1985-12-16
LU85909A1 (fr) 1986-01-29
FI843959A0 (fi) 1984-10-09
PT79331B (en) 1986-11-14
ATA320884A (de) 1988-01-15

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