AR230954A1 - Un metodo mejorado de separacion y concentracion de la proteina de actividad pro-coagulante viii:c a partir de un complejo de factor viii que contiene viii:c y viii:rp y un inmunoabsorbente empleado - Google Patents

Un metodo mejorado de separacion y concentracion de la proteina de actividad pro-coagulante viii:c a partir de un complejo de factor viii que contiene viii:c y viii:rp y un inmunoabsorbente empleado

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Publication number
AR230954A1
AR230954A1 AR291580A AR29158082A AR230954A1 AR 230954 A1 AR230954 A1 AR 230954A1 AR 291580 A AR291580 A AR 291580A AR 29158082 A AR29158082 A AR 29158082A AR 230954 A1 AR230954 A1 AR 230954A1
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Argentina
Prior art keywords
viii
employee
pro
compact
separation
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AR291580A
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English (en)
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Scripps Clinic Res
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Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y10S530/814—Cellulose or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AR291580A 1981-12-14 1982-12-14 Un metodo mejorado de separacion y concentracion de la proteina de actividad pro-coagulante viii:c a partir de un complejo de factor viii que contiene viii:c y viii:rp y un inmunoabsorbente empleado AR230954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/330,105 US4361509A (en) 1981-12-14 1981-12-14 Ultrapurification of factor VIII using monoclonal antibodies

Publications (1)

Publication Number Publication Date
AR230954A1 true AR230954A1 (es) 1984-08-31

Family

ID=23288328

Family Applications (1)

Application Number Title Priority Date Filing Date
AR291580A AR230954A1 (es) 1981-12-14 1982-12-14 Un metodo mejorado de separacion y concentracion de la proteina de actividad pro-coagulante viii:c a partir de un complejo de factor viii que contiene viii:c y viii:rp y un inmunoabsorbente empleado

Country Status (10)

Country Link
US (1) US4361509A (es)
EP (1) EP0083483B2 (es)
JP (4) JPH0723321B2 (es)
AR (1) AR230954A1 (es)
AU (1) AU545770B2 (es)
CA (1) CA1208130A (es)
DE (3) DE3280469T2 (es)
LU (1) LU88333I2 (es)
NL (1) NL930118I2 (es)
WO (1) WO1983002114A1 (es)

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US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
CA1209907A (en) * 1982-04-12 1986-08-19 Richard M. Bartholomew Method of affinity purification employing monoclonal antibodies
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4614795A (en) * 1982-08-05 1986-09-30 University Of Rochester Deglycosylated Human Factor VIII:C
US4558005A (en) * 1982-09-13 1985-12-10 University Patents, Inc. Monoclonal anti-erythropoietin
DE3485711D1 (de) * 1983-03-04 1992-06-17 Scripps Clinic Res Immunoadsorbens und verfahren zur zurueckgewinnung von vitamin-k-abhaengigen proteinen mittels dieses adsorbens.
US5614500A (en) * 1983-03-04 1997-03-25 The Scripps Research Institute Compositions containing highly purified factor IX proteins prepared by immunoaffinity chromatography
US5055557A (en) * 1983-03-04 1991-10-08 Scripps Clinic & Research Foundation Ultrapurification of factor IX and other vitamin K-dependent proteins
EP0148843B2 (en) * 1983-03-21 1994-05-04 Novo Nordisk A/S A concentrate of the antihemophilic factor viii and a process for producing it
US4649132A (en) * 1983-03-31 1987-03-10 Scripps Clinic And Research Foundation Treatment of Factor VIII inhibitors
US5362854A (en) * 1983-03-31 1994-11-08 Scripps Clinic & Research Foundation Factor VIII coagulant polypeptides: method of making
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
ZA842418B (en) * 1983-03-31 1984-11-28 Scripps Clinic Res Factor viii coagulant polypeptides and monoclonal antibodies to them
AT379510B (de) * 1983-05-20 1986-01-27 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
US4681930A (en) * 1983-09-20 1987-07-21 Hoffmann-La Roche Inc. Immune interferon and a method for its extraction and purification
ATE111490T1 (de) * 1983-10-28 1994-09-15 New England Medical Center Inc Verfahren zur isolierung eines proteins aus einer dieses protein enthaltenden mischung unter verwendung eines konformationsspezifischen antikörpers.
US6258938B1 (en) 1983-10-28 2001-07-10 Ne Medical Center Hospital, Inc. Method for the purification and isolation of blood clotting proteins using conformation specific antibodies
WO1985001961A1 (en) * 1983-10-28 1985-05-09 Genetics Institute Production of factor viii and related products
US4945041A (en) * 1983-11-17 1990-07-31 Board Of Regents Monoclonal antibodies for Mycoplasma pneumoniae and use for diagnosis of pneumonia
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
US4855238A (en) 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
JPH0764879B2 (ja) * 1984-01-12 1995-07-12 チロン コ−ポレイシヨン フアクタ−ｖ▲ｉｉｉ▼ｃに対するモノクロ−ナル抗体
US5004804A (en) * 1984-01-12 1991-04-02 Nordisk Gentofte Method and composition for preparation of factor VIIIC
US4716117A (en) * 1984-10-26 1987-12-29 Chiron Corporation Monoclonal antibodies to factor VIIIC
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5149787A (en) * 1984-05-22 1992-09-22 The Blood Center Research Foundation Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing
US4710381A (en) * 1984-05-22 1987-12-01 The Blood Center Of Southeastern Wisconsin Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing
US4604235A (en) * 1984-05-23 1986-08-05 J. T. Baker Chemical Company Purification of monoclonal antibodies
FI852866L (fi) * 1984-07-27 1986-01-28 Meloy Lab Rekombinantfaktor viii-r.
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FR2570276B1 (fr) * 1984-09-18 1987-09-04 Immunotech Sa Procede d'obtention du complexe fviii/vwf a usage therapeutique et produits en resultant
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US4560504A (en) * 1984-12-06 1985-12-24 Uop Inc. Carboxyl anchored immobilized antibodies
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
CA1297815C (en) * 1985-06-07 1992-03-24 Barry S. Coller Fibrinogen blocking monoclonal antibody
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US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
GB2178533B (en) * 1985-07-22 1989-07-19 Asahi Chemical Ind Analytical method of enzyme precursors and device therefor
DE3707213A1 (de) * 1987-03-06 1988-09-15 Behringwerke Ag Verfahren zur herstellung von faktor viii:c-mangelplasma und ein so erhaltenes mangelplasma
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
US4774323A (en) * 1987-06-29 1988-09-27 Rorer Pharmaceutical Corporation Purification of von Willebrand Factor solutions using gel permeation chromatography
US4831118A (en) * 1987-08-07 1989-05-16 Scripps Clinic And Research Foundation Flouroplastic immunoaffinity columns for purification of blood proteins
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JP2761881B2 (ja) * 1988-03-10 1998-06-04 チッソ株式会社 抗体を固定化したアフイニテイクロマトグラフイ用担体
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3904354A1 (de) 1989-02-14 1990-08-16 Behringwerke Ag Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung
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US5252711A (en) * 1989-06-01 1993-10-12 The Gillette Company Monoclonal antibodies useful in deodorizing skin and antibody fragments thereof
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US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
DE3926034C3 (de) * 1989-08-07 1996-11-21 Behringwerke Ag Verfahren zur Herstellung eines stabilen Faktors VIII
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
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US7879621B2 (en) * 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
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CN103170309B (zh) * 2013-03-12 2014-10-29 中国农业大学 一种莱克多巴胺抗体免疫亲和层析柱及其应用
CN110382547B (zh) * 2016-12-14 2023-06-06 盼展生物技术有限公司 抗凝血因子viii抗体及其用途
CN111491949B (zh) 2017-10-27 2024-01-09 株式会社绿十字控股 用于制备具有血管性血友病因子(vwf)受控含量的含有因子viii(fviii)和血管性血友病因子的组合物的方法
CA3094644A1 (en) 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods

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US3631018A (en) * 1970-05-01 1971-12-28 Baxter Laboratories Inc Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US3682881A (en) * 1970-10-02 1972-08-08 Baxter Laboratories Inc Fractionation of plasma using glycine and polyethylene glycol
US4069216A (en) * 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
US4188318A (en) * 1975-06-16 1980-02-12 Edward Shanbrom Simplified method for preparation of high yield, high purity Factor VIII concentrate
FR2363577A1 (fr) * 1976-09-03 1978-03-31 Recherches Hematologiques Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur
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CA1074698A (en) * 1977-12-19 1980-04-01 Gail A. Rock Method of collecting anti-hemophilic factor viii from blood and blood plasma
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
DE3280469T2 (de) 1996-01-04
EP0083483B2 (en) 1997-09-17
JPH0723321B2 (ja) 1995-03-15
NL930118I2 (nl) 1995-05-16
NL930118I1 (nl) 1993-11-01
US4361509A (en) 1982-11-30
CA1251152C (es) 1989-03-14
EP0083483B1 (en) 1988-04-27
LU88333I2 (fr) 1994-05-04
JPH07238034A (ja) 1995-09-12
DE19375054I2 (de) 2005-05-12
EP0083483A1 (en) 1983-07-13
AU9145682A (en) 1983-06-23
WO1983002114A1 (en) 1983-06-23
CA1208130A (en) 1986-07-22
JPS58131918A (ja) 1983-08-06
DE3278402D1 (de) 1988-06-01
JP2554848B2 (ja) 1996-11-20
JPH0616700A (ja) 1994-01-25
AU545770B2 (en) 1985-08-01
JPH08301787A (ja) 1996-11-19
DE3280469D1 (de) 1995-08-31
JPH0784480B2 (ja) 1995-09-13

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