AR228631A1 - Procedimiento para preparar nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina - Google Patents

Procedimiento para preparar nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina

Info

Publication number
AR228631A1
AR228631A1 AR287957A AR28795781A AR228631A1 AR 228631 A1 AR228631 A1 AR 228631A1 AR 287957 A AR287957 A AR 287957A AR 28795781 A AR28795781 A AR 28795781A AR 228631 A1 AR228631 A1 AR 228631A1
Authority
AR
Argentina
Prior art keywords
piperazinoquinazoline
dimetoxi
amino
procedure
new derivatives
Prior art date
Application number
AR287957A
Other languages
English (en)
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AR228631A1 publication Critical patent/AR228631A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR287957A 1980-12-29 1981-12-28 Procedimiento para preparar nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina AR228631A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8041411 1980-12-29

Publications (1)

Publication Number Publication Date
AR228631A1 true AR228631A1 (es) 1983-03-30

Family

ID=10518236

Family Applications (1)

Application Number Title Priority Date Filing Date
AR287957A AR228631A1 (es) 1980-12-29 1981-12-28 Procedimiento para preparar nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina

Country Status (23)

Country Link
US (3) US4435401A (ja)
EP (1) EP0055583B1 (ja)
JP (1) JPS57181068A (ja)
KR (1) KR830007635A (ja)
AR (1) AR228631A1 (ja)
AT (1) ATE15191T1 (ja)
AU (1) AU529367B2 (ja)
CA (1) CA1165318A (ja)
CS (1) CS236667B2 (ja)
DD (1) DD201901A5 (ja)
DE (1) DE3172089D1 (ja)
DK (1) DK152430C (ja)
ES (1) ES8405787A1 (ja)
FI (1) FI70411C (ja)
GR (1) GR76980B (ja)
IE (1) IE52232B1 (ja)
IL (1) IL64665A (ja)
NO (1) NO814454L (ja)
PH (1) PH17079A (ja)
PL (2) PL136217B1 (ja)
PT (1) PT74205B (ja)
YU (1) YU312781A (ja)
ZA (1) ZA818932B (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI70411C (fi) * 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
DE3114088A1 (de) * 1981-04-08 1982-10-28 Bayer Ag, 5090 Leverkusen Wasserloesliche triazinverbindungen, ihre herstellung und ihre verwendung
FR2521560A1 (fr) * 1982-02-17 1983-08-19 Adir Nouveaux derives de piperazine et d'homopiperazine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
CH651027A5 (de) * 1982-11-12 1985-08-30 Sandoz Ag Heterocyclische verbindungen, ihre herstellung und verwendung.
US5001125A (en) 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
JPS6267077A (ja) * 1985-09-18 1987-03-26 Mitsui Petrochem Ind Ltd キナゾリン誘導体及び医薬
JPS61140568A (ja) * 1984-12-14 1986-06-27 Mitsui Petrochem Ind Ltd キナゾリン誘導体及びそれを有効成分とする血圧降下剤
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
US5072564A (en) * 1988-10-11 1991-12-17 Campana Technology, Inc. Decorative panel
WO1992000970A1 (fr) * 1990-07-03 1992-01-23 Mitsui Petrochemical Industries, Limited Compose de pyrimidine et sel pharmaceutiquement acceptable de ce compose
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
IT1286302B1 (it) * 1996-04-10 1998-07-08 Rotta Research Lab Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso
BR9813279B1 (pt) * 1997-10-27 2010-11-16 derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina.
US6150362A (en) * 1997-12-12 2000-11-21 Henkin; Jack Triazine angiogenesis inhibitors
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
MY145822A (en) * 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
DE602005025924D1 (en) * 2004-09-20 2011-02-24 Xenon Pharmaceuticals Inc Royl-coa-desaturase
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7547698B2 (en) * 2004-09-20 2009-06-16 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
CN101208089A (zh) 2005-06-03 2008-06-25 泽农医药公司 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂
UA100684C2 (uk) 2007-03-15 2013-01-25 Новартіс Аг Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
GB201008209D0 (en) * 2010-05-17 2010-06-30 Senexis Ltd Compounds
GB201008210D0 (en) * 2010-05-17 2010-06-30 Senexis Ltd Compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496179A (en) * 1967-10-11 1970-02-17 Pfizer & Co C 2-amino-3,4-dihydroquinazolines
US3517005A (en) 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
US3900476A (en) 1973-05-17 1975-08-19 Upjohn Co 2(2'-pyrimidylamino)quinazolines and their preparation
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4062844A (en) * 1976-09-20 1977-12-13 Pfizer Inc. Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amino-6,7-dimethoxyquinazolines
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
US4171363A (en) 1977-02-22 1979-10-16 Bristol-Myers Company 1,2,3-Thiadiazole process
US4188390A (en) 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US4161595A (en) 1978-10-02 1979-07-17 Bristol-Myers Company Levulinic acid salt
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
US4351832A (en) 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines
FI70411C (fi) * 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat

Also Published As

Publication number Publication date
FI814055L (fi) 1982-06-30
CS236667B2 (en) 1985-05-15
IL64665A (en) 1985-03-31
EP0055583A1 (en) 1982-07-07
PL243280A1 (en) 1984-04-24
IL64665A0 (en) 1982-03-31
ATE15191T1 (de) 1985-09-15
AU7884681A (en) 1982-07-08
PT74205A (en) 1982-01-02
IE813053L (en) 1982-06-29
NO814454L (no) 1982-06-30
JPS57181068A (en) 1982-11-08
JPS6136831B2 (ja) 1986-08-20
FI70411C (fi) 1986-09-19
PT74205B (en) 1984-11-26
DK152430B (da) 1988-02-29
PL234523A1 (en) 1983-12-19
GR76980B (ja) 1984-09-04
US4483859A (en) 1984-11-20
PL136217B1 (en) 1986-02-28
ES508383A0 (es) 1984-06-16
PH17079A (en) 1984-05-24
DE3172089D1 (en) 1985-10-03
YU312781A (en) 1984-12-31
DD201901A5 (de) 1983-08-17
DK152430C (da) 1988-07-25
EP0055583B1 (en) 1985-08-28
US4483857A (en) 1984-11-20
PL136268B1 (en) 1986-02-28
DK569781A (da) 1982-06-30
IE52232B1 (en) 1987-08-19
KR830007635A (ko) 1983-11-04
US4435401A (en) 1984-03-06
AU529367B2 (en) 1983-06-02
CA1165318A (en) 1984-04-10
ES8405787A1 (es) 1984-06-16
FI70411B (fi) 1986-03-27
ZA818932B (en) 1982-11-24

Similar Documents

Publication Publication Date Title
AR228631A1 (es) Procedimiento para preparar nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina
AR218553A1 (es) Procedimiento para la preparacion de 1-(2-hidroxi-3-amino-propilo sustituido)-2-nitroimidazoles
AR223958A1 (es) Procedimiento para la preparacion de derivados de(4-hidroxipirrolidin-2-on-1-il)-acilamida
MX154685A (es) Procedimiento para la preparacion de derivados de urea
AR219734A1 (es) Procedimiento para la preparacion de derivados de (4-hidroxipirrolidin-2-on-1-il)-acilamida
AR221851A1 (es) Procedimiento para la preparacion de derivados de 4-piperidino-6,7-dialcoxi-quinazolina
ES504218A0 (es) Procedimiento para preparar derivados de amidas.
AR225727A1 (es) Procedimiento para la obtencion de nuevos derivados de interfennilen-8-aza-9-dioxotia-11,12-seco-prostaglandina
ES518189A0 (es) Procedimiento para preparar nuevos derivados de encefalina.
AR223487A1 (es) Procedimientos para la preparacion de nuevos derivados de 4-amino-2-piperidinoquinazolina
ES500455A0 (es) Procedimiento para la preparacion de nuevos derivados de urea
AR218296A1 (es) Procedimiento para la preparacion de nuevos derivados de 14-beta-amino-morfina
ES511058A0 (es) Procedimiento para preparar nuevos derivados de fenoxibencilo.
AR220730A1 (es) Procedimiento para la preparacion de nuevos derivados de la i-((benzoxatiolil)-metil)-4-heterociclil-piperazina
ES502649A0 (es) Procedimiento para la preparacion de derivados de fenoxi- aminopropanol substituidos
ES504787A0 (es) Procedimiento para la obtencion de derivados de diaril-imi- dazol
ES505206A0 (es) Procedimiento para la obtencion de derivados de 1-azolil-bu-tano fluorados
ES515767A0 (es) Procedimiento para preparar derivados de indano.
ES515567A0 (es) Procedimiento para preparar derivados de fenantreno.
ES516299A0 (es) "procedimiento para preparar nuevos derivados de 20,21-dinoreburnamenina".
AR228051A1 (es) Procedimiento para la preparacion de nuevos 2-piperidino-4-amino-6,7-dimetoxiquinazolinas sustituidas
ES504681A0 (es) Procedimiento para preparar derivados de 11- hidroxi-13 oxa-prostaglandina.
ES521460A0 (es) Procedimiento para preparar derivados de bencimidazol.
AR220127A1 (es) Procedimiento para la preparacion de d-homopregna-4,8-dieno-3,20-dionas
ES494603A0 (es) Procedimiento para la obtencion de nuevos derivados de 4,7- fenantrolina