AR215896A1 - Nuevas benzo (c)quinolin-9-onas utiles como compuestos intermediarios para la preparacion de nuevas benzo(c)quinolinas que tienen actividad sobre el sistema nervioso central,procedimientos para prepararlas y procedimiento para obtener dichas benzo(c)quinolinas que poseen actividad terapeutica partiendo de dichos intermediarios - Google Patents

Nuevas benzo (c)quinolin-9-onas utiles como compuestos intermediarios para la preparacion de nuevas benzo(c)quinolinas que tienen actividad sobre el sistema nervioso central,procedimientos para prepararlas y procedimiento para obtener dichas benzo(c)quinolinas que poseen actividad terapeutica partiendo de dichos intermediarios

Info

Publication number
AR215896A1
AR215896A1 AR267660A AR26766077A AR215896A1 AR 215896 A1 AR215896 A1 AR 215896A1 AR 267660 A AR267660 A AR 267660A AR 26766077 A AR26766077 A AR 26766077A AR 215896 A1 AR215896 A1 AR 215896A1
Authority
AR
Argentina
Prior art keywords
procedure
new benzo
cantuentica
benzolinas
onas
Prior art date
Application number
AR267660A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AR215896A1 publication Critical patent/AR215896A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14Unsaturated ethers
    • C07C43/178Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1782Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/10Aza-phenanthrenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/10Aza-phenanthrenes
    • C07D221/12Phenanthridines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5456Arylalkanephosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AR267660A 1976-05-17 1977-05-17 Nuevas benzo (c)quinolin-9-onas utiles como compuestos intermediarios para la preparacion de nuevas benzo(c)quinolinas que tienen actividad sobre el sistema nervioso central,procedimientos para prepararlas y procedimiento para obtener dichas benzo(c)quinolinas que poseen actividad terapeutica partiendo de dichos intermediarios AR215896A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68733276A 1976-05-17 1976-05-17
US75361976A 1976-12-22 1976-12-22
US77792877A 1977-03-15 1977-03-15

Publications (1)

Publication Number Publication Date
AR215896A1 true AR215896A1 (es) 1979-11-15

Family

ID=27418484

Family Applications (1)

Application Number Title Priority Date Filing Date
AR267660A AR215896A1 (es) 1976-05-17 1977-05-17 Nuevas benzo (c)quinolin-9-onas utiles como compuestos intermediarios para la preparacion de nuevas benzo(c)quinolinas que tienen actividad sobre el sistema nervioso central,procedimientos para prepararlas y procedimiento para obtener dichas benzo(c)quinolinas que poseen actividad terapeutica partiendo de dichos intermediarios

Country Status (23)

Country Link
JP (1) JPS6016426B2 (es)
AR (1) AR215896A1 (es)
BG (4) BG28416A4 (es)
CA (1) CA1095909A (es)
CH (2) CH626881A5 (es)
DD (1) DD130855A5 (es)
DE (1) DE2722383A1 (es)
DK (1) DK212677A (es)
ES (4) ES458812A1 (es)
FI (1) FI64141C (es)
FR (2) FR2362129A1 (es)
GR (1) GR74122B (es)
IL (1) IL52087A (es)
LU (1) LU77341A1 (es)
NL (2) NL170141C (es)
NO (1) NO147028C (es)
NZ (1) NZ184114A (es)
PH (1) PH16833A (es)
PT (1) PT66550B (es)
RO (1) RO76839A (es)
SE (1) SE7704749L (es)
SU (1) SU1098520A3 (es)
YU (2) YU156882A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802211A1 (de) * 1978-01-19 1979-07-26 Basf Ag N-substituierte 2,6-dialkylaniline und verfahren zur herstellung von n- substituierten 2,6-dialkylanilinen
US4206225A (en) * 1978-09-22 1980-06-03 Pfizer Inc. 2,10-Disubstituted dibenzo[b,d]pyrans and benzo[c]quinolines
US4228169A (en) * 1979-06-26 1980-10-14 Pfizer Inc. 1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones as antiemetic agents
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof
US4406888A (en) * 1981-01-09 1983-09-27 Pfizer Inc. Aqueous micellar solutions of levonantradol and N-methyllevonantradol and lyophilic forms thereof for reconstitution
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
CA2986195A1 (en) 2009-03-25 2010-09-30 Abbvie Inc. Substituted aryl antivrial compounds and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636058A (en) * 1966-03-25 1972-01-18 Hoffmann La Roche 7 10 - dihydro - 3 - alkyl - 6h - dibenzo(b d) pyran-6 9(8h)-diones and 5-hydroxy-7-alkyl-4-chromanones
US3507885A (en) * 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
US3649650A (en) * 1970-02-13 1972-03-14 Little Inc A Novel derivatives of tetrahydro-cannabinol
CA994791A (en) * 1971-05-12 1976-08-10 Louis S. Harris Esters of benzopyrans
US3856821A (en) * 1973-07-18 1974-12-24 Smithkline Corp ALKOXY DIBENZO (b,d) PYRANS
US3928598A (en) * 1973-11-05 1975-12-23 Lilly Co Eli Hexahydro-dibenzo{8 b,d{9 pyran-9-ones as an anti-anxiety drug
US3968125A (en) * 1973-11-05 1976-07-06 Eli Lilly And Company Dihydroxyhexahydrodibenzo[b,d]pyrans
US3944673A (en) * 1973-11-05 1976-03-16 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs
GB1522057A (en) * 1975-11-03 1978-08-23 Pfizer 9-hydroxydibenzo(b,d)pyrans and intermediates therefor

Also Published As

Publication number Publication date
FR2362129B1 (es) 1983-05-20
CH628034A5 (en) 1982-02-15
BG27897A3 (en) 1980-01-15
FR2446284A1 (fr) 1980-08-08
FR2446284B1 (es) 1983-08-26
FR2362129A1 (fr) 1978-03-17
FI771550A (es) 1977-11-18
PT66550B (en) 1978-10-18
NL170141C (nl) 1982-10-01
CA1095909A (en) 1981-02-17
PH16833A (en) 1984-03-06
IL52087A0 (en) 1977-07-31
DK212677A (da) 1977-11-18
YU156982A (en) 1983-02-28
ES458812A1 (es) 1978-08-16
PT66550A (en) 1977-06-01
FI64141B (fi) 1983-06-30
BG28416A4 (en) 1980-04-15
JPS6016426B2 (ja) 1985-04-25
AU2516277A (en) 1978-06-22
CH626881A5 (en) 1981-12-15
JPS52144672A (en) 1977-12-02
NZ184114A (en) 1982-02-23
IL52087A (en) 1981-11-30
GR74122B (es) 1984-06-06
NO147028B (no) 1982-10-11
NL7705433A (nl) 1977-11-21
NO147028C (no) 1983-01-19
SU1098520A3 (ru) 1984-06-15
YU156882A (en) 1983-02-28
ES469204A1 (es) 1978-11-16
ES469203A1 (es) 1978-11-16
ES469202A1 (es) 1978-11-16
FI64141C (fi) 1983-10-10
BG28414A4 (en) 1980-04-15
DD130855A5 (de) 1978-05-10
NL7804461A (nl) 1978-08-31
DE2722383C2 (es) 1990-06-07
SE7704749L (sv) 1977-12-05
BG28415A4 (en) 1980-04-15
DE2722383A1 (de) 1977-12-01
RO76839A (ro) 1981-05-30
NO771738L (no) 1977-11-18
LU77341A1 (es) 1977-12-13

Similar Documents

Publication Publication Date Title
AR221094A1 (es) Derivados de n-((pirimidin o triazin)-aminocarbonil)-2-carbonil-benceno-sulfonamida,procedimiento para obtenerlos,compuesto empleado como intermedio,procedimiento para obtenerlo y composicion para el control de la vegetacion indeseable que contiene los nuevos derivados
AR222013A1 (es) Procedimiento para la preparacion de derivados de i-(n-piperidino)-6,7-dimetoxi-ftalazina
MX4488E (es) Procedimiento para la preparacion de derivados de quinazolona
IT7825315A0 (it) Fenossi-benzil-ossicarbonilderivati sostituiti, procedimento per la loro preparazione e loro impiego come insetticidi e come acaricidi.
NO158624C (no) Fremgangsmaate til fremstilling av ortokiselsyretetraalkylestere eller deres homologe.
IT7820812A0 (it) Derivati di tetraidrofuran-eteri, procedimenti per la loro preparazione ed anche il loro impiego come erbicidi.
AR216448A1 (es) Nuevos derivados de tiofen,furan,pirrol o fenil amidoxima carboxilato,particularmente utiles como agentes fitohormonales y herbicidas,procedimientos para la preparacion de estos nuevos compuestos,y composiciones fitohormonales y/o herbicidas que los contienen
AR217578A1 (es) Procedimiento para la preparacion de 6,7-dialcoxi-1-piperidinoftalazinas,utiles como agentes terapeuticos
DK118578A (da) Fr&mgangsmaade til fremstilling af pyridinylaminoalkylethere,n-oxider eller physiologisk acceptable syreadditionssalte deraf
AR215896A1 (es) Nuevas benzo (c)quinolin-9-onas utiles como compuestos intermediarios para la preparacion de nuevas benzo(c)quinolinas que tienen actividad sobre el sistema nervioso central,procedimientos para prepararlas y procedimiento para obtener dichas benzo(c)quinolinas que poseen actividad terapeutica partiendo de dichos intermediarios
NO784229L (no) Nye organiske forbindelser samt fremgangsmaate for deres fremstilling
IT1062783B (it) Procedimento per la preparazione di uretani aromatici
MX5845E (es) Procedimiento para la preparacion de microcapsulas de metionina
MX6053E (es) Procedimiento microbiologico para la preparacion de derivados del sesquiterpeno
AR221051A1 (es) Procedimiento para la preparacion de derivados del acido aminodesoxiclavulanico
IT7824170A0 (it) Derivati di pentil-uree omega minuscola-sostituiti, procedimenti per la loro preparazione e loro impiego come fungicidi.
IT1092954B (it) Fenilcarbammoil-pirazoline,procedimento per la loro preparazione e il loro impiego come insetticidi
AR211006A1 (es) Procedimiento para preparar nuevos derivados de la 2-hidroxi-4-flourobutiprofenona depresores del sistema nervioso central.
ES493481A0 (es) Procedimiento para preparar 2,7-dioxo-2,7-dihidroben- zo-(1:2-b;5:6-b1)difurano o -dipirrol
AR217688A1 (es) Procedimiento para la preparacion de derivados de trans-2-sustituido-5-aril-2,3,4,4a,5,9b-hexahidro-1h-pirido(4,3-b)-indol
IT1058733B (it) Procedimento per la preparazione di uretani aromatici
AR217426A1 (es) Procedimiento para la preparacion de nuevos derivados de 7-(3-indoliloxi,naftiloxi o fenoxi-2-hidroxi-propilamino-alquil)-teofilina
AR219296A1 (es) Alfa-aril-(trifluorcetil)-aminas utiles como intermediarios para preparar compuestos terapeuticos,y desprovistas de propiedades farmacologicas,y procedimiento para su obtencion
NO782069L (no) Fremgangsmaate til fremstilling av nye nitrosourinstoff-derivater
DK146540C (da) Fremgangsmaade til fremstilling af alkaloider af leurosin-typen, eller syreadditionssalte deraf