AR129168A2 - Materiales y métodos para la unión de lectina tipo ig de unión a ácido siálico - Google Patents

Materiales y métodos para la unión de lectina tipo ig de unión a ácido siálico

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Publication number
AR129168A2
AR129168A2 ARP230101027A ARP230101027A AR129168A2 AR 129168 A2 AR129168 A2 AR 129168A2 AR P230101027 A ARP230101027 A AR P230101027A AR P230101027 A ARP230101027 A AR P230101027A AR 129168 A2 AR129168 A2 AR 129168A2
Authority
AR
Argentina
Prior art keywords
constant region
domain
fragment
isolated protein
seq
Prior art date
Application number
ARP230101027A
Other languages
English (en)
Inventor
Patrick John Doonan
Rajkumar Ganesan
Mehabaw Getahun Derebe
Sathyadevi Venkataramani
Sanjaya Singh
Iqbal S Grewal
Karla R Wiehagen
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of AR129168A2 publication Critical patent/AR129168A2/es

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

La invención proporciona dominios de unión a antígeno que se unen a la proteína CD33 del antígeno de la superficie de células mieloides que comprende los dominios de unión a antígeno que se unen a CD33, polinucleótidos que los codifican, vectores, células huésped, métodos para fabricarlos y usarlos. Reivindicación 1: Una proteína aislada que se une a CD33, caracterizada porque la proteína aislada comprende una HCDR1, una HCDR2, una HCDR3, una LCDR1, una LCDR2 y una LCDR3 de SEQ ID Nº 253, 256, 259, 265, 74 y 269, respectivamente. Reivindicación 2: La proteína aislada de la reivindicación 1, caracterizada porque la proteína aislada comprende una región variable de cadena pesada (VH) de SEQ ID Nº 262, y una región variable de cadena ligera (VL) de SEQ ID Nº 271. Reivindicación 3: La proteína aislada de la reivindicación 1 o 2, caracterizada porque la proteína aislada es un Fab, un scFv, un (scFv)₂, un Fv, un F(ab’)₂, un Fd, un dAb, o un VHH. Reivindicación 6: La proteína aislada de una cualquiera de las reivindicaciones 1 - 4, caracterizada porque la proteína se conjuga con un resto que prolonga o modula la semivida seleccionado de: una inmunoglobulina (Ig); un fragmento de la Ig; una región constante de Ig; un fragmento de la región constante de Ig; una región Fc; un fragmento de la región constante de Ig que comprende una región Fc; un fragmento de la región constante de Ig que comprende un dominio CH2; un fragmento de la región constante de Ig que comprende un dominio CH3; un fragmento de la región constante de Ig que comprende un dominio CH2 y un dominio CH3; un fragmento de la región constante de Ig que comprende al menos una parte de una bisagra, un dominio CH2 y un dominio CH3; un fragmento de la región constante de Ig que comprende una bisagra, un dominio CH2 y un dominio CH3; transferrina; albúmina; un dominio de unión a albúmina; o polietilenglicol. Reivindicación 10: La proteína aislada de una cualquiera de las reivindicaciones 6 - 9, caracterizada porque la región constante de Ig o el fragmento de la región constante de Ig es un isotipo de IgG1, IgG2, IgG3 o IgG4, donde, opcionalmente, la región constante de Ig o el fragmento de la región constante de Ig es una IgG1; donde, opcionalmente el fragmento de la región constante de Ig tiene la secuencia de SEQ ID Nº 277 o 278. Reivindicación 15: La proteína aislada de una cualquiera de las reivindicaciones 1 - 10, caracterizada porque es para su uso en un método para tratar un cáncer que expresa CD33 en un sujeto, donde el cáncer que expresa CD33 es un cáncer hematológico seleccionado de: una leucemia, un linfoma, un mieloma múltiple, leucemia mieloide aguda (AML), síndrome mielodisplásico (MDS), leucemia linfocítica aguda (ALL), linfoma difuso de linfocitos B grandes (DLBCL), leucemia mieloide crónica (CML) o neoplasia de células dendríticas plasmocitoides blásticas (DPDCN).
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