CL2023000909A1 - Materiales y métodos para la unión de siglec-3/cd33 (divisional).. - Google Patents

Materiales y métodos para la unión de siglec-3/cd33 (divisional)..

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Publication number
CL2023000909A1
CL2023000909A1 CL2023000909A CL2023000909A CL2023000909A1 CL 2023000909 A1 CL2023000909 A1 CL 2023000909A1 CL 2023000909 A CL2023000909 A CL 2023000909A CL 2023000909 A CL2023000909 A CL 2023000909A CL 2023000909 A1 CL2023000909 A1 CL 2023000909A1
Authority
CL
Chile
Prior art keywords
methods
siglec
divisional
binding
materials
Prior art date
Application number
CL2023000909A
Other languages
English (en)
Inventor
Singh Sanjaya
Ganesan Rajkumar
Venkataramani Sathyadevi
John Doonan Patrick
Getahun Derebe Mehabaw
S Grewal Iqbal
R Wiehagen Karla
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of CL2023000909A1 publication Critical patent/CL2023000909A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/4643—Vertebrate antigens
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    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Package Frames And Binding Bands (AREA)
  • Seal Device For Vehicle (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención proporciona dominios de unión a antígeno que se unen a la proteína CD33 del antígeno de la superficie de células mieloides que comprende los dominios de unión a antígeno que se unen a CD33, polinucleótidos que los codifican, vectores, células huésped, métodos para fabricarlos y usarlos.
CL2023000909A 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional).. CL2023000909A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062989120P 2020-03-13 2020-03-13
US202062989071P 2020-03-13 2020-03-13
US202062989230P 2020-03-13 2020-03-13
US202062989093P 2020-03-13 2020-03-13
US202062989187P 2020-03-13 2020-03-13

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CL2023000909A1 true CL2023000909A1 (es) 2023-09-29

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CL2022002488A CL2022002488A1 (es) 2020-03-13 2022-09-12 Materiales y métodos para la unión de siglec-3/cd33.
CL2023000910A CL2023000910A1 (es) 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional).
CL2023000911A CL2023000911A1 (es) 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional)
CL2023000909A CL2023000909A1 (es) 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional)..

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CL2022002488A CL2022002488A1 (es) 2020-03-13 2022-09-12 Materiales y métodos para la unión de siglec-3/cd33.
CL2023000910A CL2023000910A1 (es) 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional).
CL2023000911A CL2023000911A1 (es) 2020-03-13 2023-03-29 Materiales y métodos para la unión de siglec-3/cd33 (divisional)

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US (3) US20230365684A1 (es)
EP (4) EP4233895A3 (es)
JP (1) JP2023517660A (es)
KR (4) KR20230051616A (es)
CN (1) CN115768482A (es)
AU (4) AU2021235564A1 (es)
BR (1) BR112022018176A2 (es)
CA (1) CA3171113A1 (es)
CL (4) CL2022002488A1 (es)
CO (1) CO2022013823A2 (es)
EC (1) ECSP22071278A (es)
IL (4) IL296263A (es)
JO (1) JOP20220220A1 (es)
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PE (4) PE20230001A1 (es)
TW (1) TW202144418A (es)
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WO (1) WO2021181366A1 (es)

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KR20240055002A (ko) * 2021-09-13 2024-04-26 얀센 바이오테크 인코포레이티드 암 치료를 위한 CD33 x Vδ2 다중특이성 항체

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