AR127532A1 - Composición farmacéutica que comprende ibuprofeno y arginina - Google Patents
Composición farmacéutica que comprende ibuprofeno y argininaInfo
- Publication number
- AR127532A1 AR127532A1 ARP220103280A ARP220103280A AR127532A1 AR 127532 A1 AR127532 A1 AR 127532A1 AR P220103280 A ARP220103280 A AR P220103280A AR P220103280 A ARP220103280 A AR P220103280A AR 127532 A1 AR127532 A1 AR 127532A1
- Authority
- AR
- Argentina
- Prior art keywords
- arginine
- ibuprofen
- pharmaceutical composition
- add
- na2co3
- Prior art date
Links
- 239000004475 Arginine Substances 0.000 title abstract 6
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract 6
- 229960001680 ibuprofen Drugs 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 2
- 235000017550 sodium carbonate Nutrition 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 210000000981 epithelium Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Una composición farmacéutica para aplicar sobre el epitelio pulmonar para el tratamiento de enfermedades respiratorias, caracterizada porque comprende ibuprofeno, arginina, solubilizados en una solución acuosa hipertónica a un pH entre 7,5 y 9,5 donde la relación molar arginina / ibuprofeno es menor a 6,5. Reivindicación 22: Un proceso de fabricación de una composición farmacéutica de cualquiera de las reivindicaciones 13 - 18, caracterizado porque dicho proceso comprende los siguientes pasos: a) mezclar dicho ibuprofeno en su forma ácida con solución acuosa de Na₂CO₃ a una temperatura mayor a 40º y agitar para mantener su suspensión; b) añadir dicha arginina en el paso a); c) añadir NaOH o Na₂CO₃ para alcanzar un valor de pH entre 7,5 y 9,5 y agitar para permitir una solubilización completa de dicho ibuprofeno y arginina para obtener una concentración entre 1 y 250 mg/mL para ibuprofeno y entre 1 y 50 mg/mL para arginina; d) agregar dicha sal apta para el consumo humano a la preparación de dicho paso c), en una concentración de 0,3 a 1,0 M y; e) filtrar la preparación en dicho paso d), a través de un filtro de poro de 0,22 micras.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163284909P | 2021-12-01 | 2021-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR127532A1 true AR127532A1 (es) | 2024-02-07 |
Family
ID=84537275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220103280A AR127532A1 (es) | 2021-12-01 | 2022-11-29 | Composición farmacéutica que comprende ibuprofeno y arginina |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR127532A1 (es) |
| WO (1) | WO2023100127A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100851679B1 (ko) * | 2001-11-02 | 2008-08-13 | 큠버랜드 파마슈티컬즈 인코포레이티드 | 2-(4-이소부틸페닐)프로피온산의 약학 조성물 |
| AR102172A1 (es) * | 2015-10-05 | 2017-02-08 | Química Luar S R L | Una composición farmacéutica bactericida y virucida |
-
2022
- 2022-11-29 AR ARP220103280A patent/AR127532A1/es unknown
- 2022-12-01 WO PCT/IB2022/061638 patent/WO2023100127A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023100127A1 (en) | 2023-06-08 |
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