AR125970A1 - Formulaciones de suspensión acuosa para administración oral que comprenden un compuesto de carbamato - Google Patents
Formulaciones de suspensión acuosa para administración oral que comprenden un compuesto de carbamatoInfo
- Publication number
- AR125970A1 AR125970A1 ARP220101384A ARP220101384A AR125970A1 AR 125970 A1 AR125970 A1 AR 125970A1 AR P220101384 A ARP220101384 A AR P220101384A AR P220101384 A ARP220101384 A AR P220101384A AR 125970 A1 AR125970 A1 AR 125970A1
- Authority
- AR
- Argentina
- Prior art keywords
- aqueous formulation
- disease
- poloxamer
- formulation according
- formula
- Prior art date
Links
- -1 CARBAMATE COMPOUND Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000007900 aqueous suspension Substances 0.000 title 1
- 239000013011 aqueous formulation Substances 0.000 abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 3
- 229920001983 poloxamer Polymers 0.000 abstract 3
- 229960000502 poloxamer Drugs 0.000 abstract 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001451 polypropylene glycol Polymers 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006731 (C1-C8) thioalkoxy group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- 229920001400 block copolymer Polymers 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 230000000391 smoking effect Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Reivindicación 1: Una formulación acuosa que comprende un compuesto de carbamato que tiene la fórmula (1), o un solvato, hidrato o una sal farmacéuticamente aceptable de él, un poloxámero, y un vehículo acuoso: fórmula (1) en la cual, R¹ y R² se seleccionan, cada uno independientemente, entre el grupo que consiste en -H, halo, alquilo C₁-C₈, haloalquilo C₁-C₈, tioalcoxi C₁-C₈, y alcoxi C₁-C₈ y uno de A¹ y A² es CH, y el otro es N, en donde la formulación acuosa se encuentra en forma de formulación de suspensión. Reivindicación 5: La formulación acuosa de acuerdo con la reivindicación 1, la cual contiene los compuestos de carbamato que tienen la fórmula (1) en una concentración desde alrededor de 1 mg/ml hasta aproximadamente 100 mg/ml. Reivindicación 6: La formulación acuosa de acuerdo con la reivindicación 1, en la cual el poloxámero es un copolímero en bloque de tipo ABA que consiste en entre 75 y 85% de unidades de óxido de polietileno (PEO) y entre 15 y 25% de unidades de óxido de polipropileno (PPO). Reivindicación 9: La formulación acuosa de acuerdo con la reivindicación 1, la cual contiene el poloxámero en una concentración desde alrededor de 0,1 mg/ml hasta aproximadamente 1,5 mg/ml. Reivindicación 35: Un método para tratar una enfermedad que comprende: administrar la formulación acuosa de acuerdo con la reivindicación 1 a un sujeto que lo necesita, en el cual, la enfermedad es una enfermedad del sistema nervioso central. Reivindicación 36: El método de acuerdo con la reivindicación 35, en el cual la enfermedad del sistema nervioso central se selecciona entre el grupo que consiste en ansiedad, depresión, convulsión, epilepsia, migraña, trastorno bipolar, toxicomanía, tabaquismo, trastorno por déficit de atención con hiperactividad (ADHD), obesidad, trastornos del sueño, dolor neuropático, ACV, trastornos cognitivos, neurodegeneración, y espasmo muscular.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163194276P | 2021-05-28 | 2021-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR125970A1 true AR125970A1 (es) | 2023-08-30 |
Family
ID=84228939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101384A AR125970A1 (es) | 2021-05-28 | 2022-05-26 | Formulaciones de suspensión acuosa para administración oral que comprenden un compuesto de carbamato |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230013175A1 (es) |
| EP (1) | EP4346768A1 (es) |
| JP (1) | JP2024519421A (es) |
| KR (1) | KR20240013733A (es) |
| CN (1) | CN117597108A (es) |
| AR (1) | AR125970A1 (es) |
| AU (1) | AU2022281946A1 (es) |
| BR (1) | BR112023024498A2 (es) |
| CA (1) | CA3217927A1 (es) |
| CL (1) | CL2023003411A1 (es) |
| IL (1) | IL308619A (es) |
| MX (1) | MX2023013474A (es) |
| TW (1) | TW202313007A (es) |
| WO (1) | WO2022250499A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007007182A2 (en) * | 2005-07-08 | 2007-01-18 | Aurobindo Pharma Limited | Solid and liquid dosage forms of an antiepileptic agent |
| WO2019058354A1 (en) * | 2017-09-25 | 2019-03-28 | Jubilant Generics Limited | SUSPENSION OF ESLICARBAZÉPINE |
| IL293096A (en) * | 2019-11-22 | 2022-07-01 | Sk Biopharmaceuticals Co Ltd | A pharmaceutical preparation for oral administration containing a carbamate compound and a method for its preparation |
-
2022
- 2022-05-26 AR ARP220101384A patent/AR125970A1/es unknown
- 2022-05-27 CN CN202280038180.5A patent/CN117597108A/zh active Pending
- 2022-05-27 BR BR112023024498A patent/BR112023024498A2/pt unknown
- 2022-05-27 US US17/826,289 patent/US20230013175A1/en active Pending
- 2022-05-27 MX MX2023013474A patent/MX2023013474A/es unknown
- 2022-05-27 KR KR1020237039825A patent/KR20240013733A/ko unknown
- 2022-05-27 AU AU2022281946A patent/AU2022281946A1/en active Pending
- 2022-05-27 EP EP22811690.1A patent/EP4346768A1/en active Pending
- 2022-05-27 IL IL308619A patent/IL308619A/en unknown
- 2022-05-27 TW TW111119882A patent/TW202313007A/zh unknown
- 2022-05-27 CA CA3217927A patent/CA3217927A1/en active Pending
- 2022-05-27 JP JP2023573111A patent/JP2024519421A/ja active Pending
- 2022-05-27 WO PCT/KR2022/007581 patent/WO2022250499A1/en active Application Filing
-
2023
- 2023-11-16 CL CL2023003411A patent/CL2023003411A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2023003411A1 (es) | 2024-05-03 |
| MX2023013474A (es) | 2023-12-15 |
| EP4346768A1 (en) | 2024-04-10 |
| IL308619A (en) | 2024-01-01 |
| CA3217927A1 (en) | 2022-12-01 |
| CN117597108A (zh) | 2024-02-23 |
| AU2022281946A1 (en) | 2023-11-23 |
| TW202313007A (zh) | 2023-04-01 |
| KR20240013733A (ko) | 2024-01-30 |
| BR112023024498A2 (pt) | 2024-02-15 |
| WO2022250499A1 (en) | 2022-12-01 |
| US20230013175A1 (en) | 2023-01-19 |
| JP2024519421A (ja) | 2024-05-13 |
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