AR124406A1 - Dispersiones sólidas amorfas - Google Patents
Dispersiones sólidas amorfasInfo
- Publication number
- AR124406A1 AR124406A1 ARP210103551A ARP210103551A AR124406A1 AR 124406 A1 AR124406 A1 AR 124406A1 AR P210103551 A ARP210103551 A AR P210103551A AR P210103551 A ARP210103551 A AR P210103551A AR 124406 A1 AR124406 A1 AR 124406A1
- Authority
- AR
- Argentina
- Prior art keywords
- solid dispersion
- weight
- dispersion according
- hypromellose
- disease
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 9
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 6
- 229960003943 hypromellose Drugs 0.000 abstract 4
- 208000010877 cognitive disease Diseases 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000155 melt Substances 0.000 abstract 2
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 abstract 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002942 Apathy Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 229920002785 Croscarmellose sodium Polymers 0.000 abstract 1
- 208000014094 Dystonic disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 238000000889 atomisation Methods 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 239000008119 colloidal silica Substances 0.000 abstract 1
- 229960001681 croscarmellose sodium Drugs 0.000 abstract 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 208000010118 dystonia Diseases 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000009474 hot melt extrusion Methods 0.000 abstract 1
- 239000012943 hotmelt Substances 0.000 abstract 1
- 229960001021 lactose monohydrate Drugs 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Reivindicación 1: Una dispersión sólida caracterizada porque es de 2-(3,5-dicloro-1-metil-indazol-4-il)-1-[(1S,3R)-3-(hidroximetil)-5-(1-hidroxi-1)amorfo-metil-etil)-1-metil3,4-dihidro-1H-isoquinolin-2-il]etanona de fórmula (1) y una matriz polimérica. Reivindicación 8: Un proceso de preparación de una dispersión sólida de acuerdo a la reivindicación 1 mediante secado por pulverización caracterizado porque comprende los siguientes pasos: (i) disolver el compuesto de fórmula (1a) y acetato de hidroxipropilmetilcelulosa, copolímero N-vinil-2-pirrolidona / acetato de vinilo, polivinilpirrolidona, ftalato de hipromelosa o hipromelosa en un disolvente; (ii) transportar la solución obtenida como resultado del paso (i) a una cámara de atomización; (iii) poner en contacto las gotitas formadas como resultado de la etapa (ii) con un gas de secado en caliente; (iv) evaporar el disolvente; (v) separar la dispersión sólida obtenida del gas de secado. Reivindicación 9: Un proceso de preparación de una dispersión sólida de acuerdo a la reivindicación 1 por extrusión por fusión en caliente caracterizado porque comprende los siguientes pasos: (i) Mezclar el compuesto de fórmula (1a) y acetato de hidroxipropil metil celulosa, copolímero N-vinil-2-pirrolidona / acetato de vinilo, polivinilpirrolidona, ftalato de hipromelosa o hipromelosa; (ii) Introducir la mezcla obtenida en la etapa (i) en una extrusora por fusión en caliente en la que una sección hecha de cilindro y tornillos transporta la mezcla de forma continua a una temperatura superior a 150ºC hasta que se obtiene una masa fundida; (iii) Enfriar la masa fundida obtenida en la etapa (ii) a temperatura ambiente. Reivindicación 10: Una composición farmacéutica caracterizada porque comprende la dispersión sólida de acuerdo a la reivindicación 1 en asociación con uno o más excipientes farmacéuticamente aceptables. Reivindicación 11: Un producto farmacéutico caracterizado porque comprende una dispersión sólida de acuerdo a la reivindicación 1 que consiste en un comprimido que comprende: Entre aproximadamente 20% y aproximadamente 60% por peso de dispersión sólida amorfa; Entre aproximadamente 10% y aproximadamente 50% por peso de lactosa monohidratada; Entre aproximadamente 10% y aproximadamente 50% por peso de celulosa microcristalina; Entre aproximadamente 1% y aproximadamente 5% por peso de croscarmelosa sódica; Entre aproximadamente 0,1% y aproximadamente 2% por peso de sílice coloidal anhidra; y Entre aproximadamente 0,1% y aproximadamente 5% por peso de estearato de magnesio; En comparación con el peso total del comprimido sin recubrimiento. Reivindicación 12: Una dispersión sólida según una cualquiera de las reivindicaciones 1 - 7 o una composición farmacéutica de acuerdo a la reivindicación 10 u 11, caracterizada porque es para su uso en el tratamiento y/o prevención de síntomas cognitivos y negativos en la esquizofrenia, deterioro cognitivo relacionado con la terapia neuroléptica, deterioro cognitivo leve (MCI), impulsividad, trastorno por déficit de atención e hiperactividad (ADHD), enfermedad de Parkinson y otros trastornos del movimiento, distonía, demencia de Parkinson, enfermedad de Huntington, demencia con cuerpos de Lewy, adicción a las drogas y enfermedad de Alzheimer, trastornos del sueño, apatía, traumatismo lesión traumática de la médula espinal o dolor neuropático.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20215253 | 2020-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124406A1 true AR124406A1 (es) | 2023-03-22 |
Family
ID=73855649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210103551A AR124406A1 (es) | 2020-12-18 | 2021-12-17 | Dispersiones sólidas amorfas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20240000769A1 (es) |
| EP (1) | EP4262756A1 (es) |
| JP (1) | JP2023553457A (es) |
| KR (1) | KR20230121867A (es) |
| CN (1) | CN116685308A (es) |
| AR (1) | AR124406A1 (es) |
| AU (1) | AU2021401128A1 (es) |
| CA (1) | CA3201298A1 (es) |
| CL (1) | CL2023001395A1 (es) |
| CO (1) | CO2023007098A2 (es) |
| IL (1) | IL303688A (es) |
| MX (1) | MX2023007154A (es) |
| PE (1) | PE20240021A1 (es) |
| TW (1) | TW202241424A (es) |
| WO (1) | WO2022129267A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2978751B1 (en) * | 2013-03-25 | 2018-12-05 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| WO2015141662A1 (ja) * | 2014-03-18 | 2015-09-24 | 武田薬品工業株式会社 | 固体分散体 |
| CA2963951C (en) * | 2014-10-08 | 2023-02-28 | Ucb Biopharma Sprl | Tetrahydroisoquinoline derivatives |
| BR112018070363A2 (pt) * | 2016-04-13 | 2019-01-29 | Ucb Biopharma Sprl | derivados de tetraidroisoquinolina |
| US20220259179A1 (en) | 2019-07-01 | 2022-08-18 | UCB Biopharma SRL | A Substituted Tetrahydroisoquinoiline Derivative as a D1 Positive Allosteric Modulator |
-
2021
- 2021-12-16 JP JP2023535726A patent/JP2023553457A/ja active Pending
- 2021-12-16 TW TW110147172A patent/TW202241424A/zh unknown
- 2021-12-16 US US18/267,925 patent/US20240000769A1/en active Pending
- 2021-12-16 KR KR1020237024337A patent/KR20230121867A/ko unknown
- 2021-12-16 WO PCT/EP2021/086061 patent/WO2022129267A1/en active Application Filing
- 2021-12-16 PE PE2023001827A patent/PE20240021A1/es unknown
- 2021-12-16 CN CN202180084509.7A patent/CN116685308A/zh active Pending
- 2021-12-16 IL IL303688A patent/IL303688A/en unknown
- 2021-12-16 CA CA3201298A patent/CA3201298A1/en active Pending
- 2021-12-16 AU AU2021401128A patent/AU2021401128A1/en active Pending
- 2021-12-16 MX MX2023007154A patent/MX2023007154A/es unknown
- 2021-12-16 EP EP21839495.5A patent/EP4262756A1/en active Pending
- 2021-12-17 AR ARP210103551A patent/AR124406A1/es unknown
-
2023
- 2023-05-16 CL CL2023001395A patent/CL2023001395A1/es unknown
- 2023-05-30 CO CONC2023/0007098A patent/CO2023007098A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4262756A1 (en) | 2023-10-25 |
| CL2023001395A1 (es) | 2023-12-29 |
| KR20230121867A (ko) | 2023-08-21 |
| IL303688A (en) | 2023-08-01 |
| CO2023007098A2 (es) | 2023-06-09 |
| CN116685308A (zh) | 2023-09-01 |
| TW202241424A (zh) | 2022-11-01 |
| US20240000769A1 (en) | 2024-01-04 |
| CA3201298A1 (en) | 2022-06-23 |
| AU2021401128A1 (en) | 2023-07-13 |
| WO2022129267A1 (en) | 2022-06-23 |
| MX2023007154A (es) | 2023-06-28 |
| JP2023553457A (ja) | 2023-12-21 |
| PE20240021A1 (es) | 2024-01-04 |
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