AR123672A2 - Conjugados de anticuerpo fármaco - Google Patents

Conjugados de anticuerpo fármaco

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Publication number
AR123672A2
AR123672A2 ARP200100581A ARP200100581A AR123672A2 AR 123672 A2 AR123672 A2 AR 123672A2 AR P200100581 A ARP200100581 A AR P200100581A AR P200100581 A ARP200100581 A AR P200100581A AR 123672 A2 AR123672 A2 AR 123672A2
Authority
AR
Argentina
Prior art keywords
alkynyl
alkenyl
alkyl
coora
cora
Prior art date
Application number
ARP200100581A
Other languages
English (en)
Inventor
Garca-Ibarrola Mara Garranzo
Solloso Andrs Francesch
Correa Juan Manuel Domnguez
Alonso Mara Jos Muoz
Madrid Francisco Snchez
Hernandez Juan Manuel Zapata
Arroyo Alicia Garca
Pecharromn Mara Angeles Ursa
Marchante Mara Del Carmen Cuevas
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of AR123672A2 publication Critical patent/AR123672A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Conjugados de fármaco de fórmula [D-(X)ᵇ-(AA)ʷ-(L)-]ₙ-Ab en la que: D es un resto de fármaco que tiene la siguiente fórmula (1) o una sal, éster, solvato, tautómero o estereoisómero aceptable desde el punto de vista farmacéutico, en la que: A se selecciona de los compuestos de fórmula (2) y (3); R¹, R² y R³ es H, ORᵃ, OCORᵃ, OCOORᵃ, alquilo, alquenilo, alquinilo, etc.; R³’ es, CORᵃ, COORᵃ, CONRᵃRᵇ, etc.; cada uno de R⁴ a R¹⁰ y R¹² es alquilo, alquenilo, o alquinilo; R¹¹ es H, CORᵃ, COORᵃ, alquilo, alquenilo o alquinilo, o R¹¹ y R¹² + N + C átomos a los cuales se unen pueden formar un grupo heterocíclico; cada uno de R¹³ y R¹⁴ es H, CORᵃ, COORᵃ, alquilo, alquenilo o alquinilo; cada uno de Rᵃ y Rᵇ es H, alquilo, alquenilo, alquinilo, etc.; cada línea punteada representa un enlace adicional opcional; X es un grupo extensor; AA es una unidad de aminoácido; L es un grupo conector; w es 0 a 12; b es 0 ó 1; Ab es un resto que comprende al menos un sitio de unión al antígeno, y n es la relación del grupo [D-(X)ᵇ-(AA)ʷ-(L)-] al resto que comprende al menos un sitio de unión al antígeno y está en el intervalo de 1 a 20, son útiles en el tratamiento de cáncer.
ARP200100581A 2013-05-31 2020-03-03 Conjugados de anticuerpo fármaco AR123672A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1309807.4A GB201309807D0 (en) 2013-05-31 2013-05-31 Antibody drug conjugates

Publications (1)

Publication Number Publication Date
AR123672A2 true AR123672A2 (es) 2023-01-04

Family

ID=48805601

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP140102164A AR096461A1 (es) 2013-05-31 2014-06-03 Anticuerpos conjugados de fármacos
ARP200100581A AR123672A2 (es) 2013-05-31 2020-03-03 Conjugados de anticuerpo fármaco

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP140102164A AR096461A1 (es) 2013-05-31 2014-06-03 Anticuerpos conjugados de fármacos

Country Status (29)

Country Link
US (2) US11224663B2 (es)
EP (1) EP3003386B1 (es)
JP (1) JP6412114B2 (es)
KR (2) KR102448393B1 (es)
CN (1) CN105451775B (es)
AR (2) AR096461A1 (es)
AU (1) AU2014273052B2 (es)
BR (1) BR112015029816B1 (es)
CA (1) CA2914041C (es)
CL (1) CL2015003481A1 (es)
CY (1) CY1122662T1 (es)
DK (1) DK3003386T3 (es)
ES (1) ES2778045T3 (es)
GB (1) GB201309807D0 (es)
HR (1) HRP20200032T1 (es)
IL (1) IL242571B (es)
LT (1) LT3003386T (es)
MX (1) MX356431B (es)
MY (1) MY176579A (es)
NZ (1) NZ715646A (es)
PL (1) PL3003386T3 (es)
PT (1) PT3003386T (es)
RS (1) RS59855B1 (es)
RU (1) RU2669812C2 (es)
SG (1) SG11201509563UA (es)
SI (1) SI3003386T1 (es)
UA (1) UA119327C2 (es)
WO (1) WO2014191578A1 (es)
ZA (1) ZA201508487B (es)

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WO2016089610A1 (en) * 2014-12-06 2016-06-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
JP6903055B2 (ja) * 2015-08-03 2021-07-14 イーエヌビー・セラピューティクス・インク Ｅｔｂｒ活性化に関連した癌を治療するための組成物及び方法
CN114272389B (zh) 2016-03-02 2023-04-18 卫材研究发展管理有限公司 基于艾日布林的抗体-药物偶联物和使用方法
EP3381474A1 (en) * 2017-03-27 2018-10-03 Alfasigma S.p.A. Histone deacetylase inhibitors-based antibody drug conjugates (adcs) and use in therapy
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN118271394A (zh) * 2017-11-30 2024-07-02 思进公司 药物接头化合物的制备方法
EP3716982A4 (en) * 2017-12-01 2021-08-11 AbbVie Inc. ANTI-CD40 ANTIBODY INGREDIENT CONJUGATES
KR20200108002A (ko) 2018-01-08 2020-09-16 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 항체-접합체
MA53933A (fr) * 2018-10-21 2021-08-25 Slsg Ltd Llc Poly-immunothérapie pour le traitement du cancer du sein triple-négatif
EP3898651A2 (en) 2018-12-21 2021-10-27 Regeneron Pharmaceuticals, Inc. Tubulysins and protein-tubulysin conjugates
EP3964236A4 (en) * 2019-05-02 2023-05-31 LegoChem Biosciences, Inc. LIGAND-DRUG CONJUGATE COMPRISING A LINKER HAVING A TRIS STRUCTURE
WO2020222573A1 (ko) * 2019-05-02 2020-11-05 주식회사 레고켐 바이오사이언스 트리스 구조를 가지는 링커를 포함하는 리간드-약물 접합체
MX2021013657A (es) * 2019-05-10 2022-02-21 Takeda Pharmaceuticals Co Conjugados de anticuerpo y farmaco.
EP3760233B1 (en) * 2019-05-20 2023-07-12 MabPlex International Co., Ltd. One-pot preparation process for antibody drug conjugate intermediate
CN114262377B (zh) * 2021-10-28 2024-03-22 新疆优迈生物技术有限公司 一种阻断cd70与其配体cd27结合的抗人cd70纳米抗体的制备方法及其编码序列

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US7659241B2 (en) 2002-07-31 2010-02-09 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
AU2004213053C1 (en) * 2003-02-20 2009-07-16 Seagen Inc. Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
WO2006060533A2 (en) 2004-12-01 2006-06-08 Genentech, Inc. Conjugates of 1, 8-bis-naphthalimides with an antibody
EP1864682A1 (en) * 2006-06-09 2007-12-12 Sanofi-Aventis Leptomycin derivatives
EP2032551B9 (en) * 2006-06-16 2012-02-29 Pharma Mar, S.A. Antitumoral dihydropyran-2-one compounds
UA119963C2 (uk) * 2007-12-20 2019-09-10 Фарма Мар, С.А. Протипухлинні сполуки
ES2728163T3 (es) 2008-05-23 2019-10-22 Wyeth Llc Compuestos de triazina como inhibidores de PI3 cinasa y mTOR
US8900589B2 (en) 2008-07-15 2014-12-02 Genetech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
WO2010149688A2 (en) * 2009-06-24 2010-12-29 Pharma Mar, S.A. Antitumoral compounds

Also Published As

Publication number Publication date
AR096461A1 (es) 2015-12-30
ZA201508487B (en) 2017-11-29
KR20210156848A (ko) 2021-12-27
JP6412114B2 (ja) 2018-10-24
US20220168436A1 (en) 2022-06-02
LT3003386T (lt) 2020-01-27
AU2014273052B2 (en) 2018-03-08
PT3003386T (pt) 2020-01-21
RU2015156499A3 (es) 2018-03-27
US20160129128A1 (en) 2016-05-12
CN105451775B (zh) 2019-09-06
EP3003386A1 (en) 2016-04-13
HRP20200032T1 (hr) 2020-03-20
MX356431B (es) 2018-05-29
SG11201509563UA (en) 2015-12-30
IL242571B (en) 2019-10-31
DK3003386T3 (da) 2020-01-27
MX2015016417A (es) 2016-07-05
RU2669812C2 (ru) 2018-10-16
UA119327C2 (uk) 2019-06-10
EP3003386B1 (en) 2019-10-16
CL2015003481A1 (es) 2016-08-19
ES2778045T3 (es) 2020-08-07
RU2015156499A (ru) 2017-06-30
NZ715646A (en) 2019-05-31
CA2914041A1 (en) 2014-12-04
BR112015029816A2 (pt) 2017-07-25
CA2914041C (en) 2021-12-07
BR112015029816B1 (pt) 2022-10-04
CY1122662T1 (el) 2021-03-12
KR102448393B1 (ko) 2022-09-28
GB201309807D0 (en) 2013-07-17
CN105451775A (zh) 2016-03-30
RS59855B1 (sr) 2020-02-28
SI3003386T1 (sl) 2020-03-31
US11224663B2 (en) 2022-01-18
PL3003386T3 (pl) 2020-04-30
KR20160030132A (ko) 2016-03-16
KR102340681B1 (ko) 2021-12-20
JP2016526042A (ja) 2016-09-01
MY176579A (en) 2020-08-17
WO2014191578A1 (en) 2014-12-04
AU2014273052A1 (en) 2016-01-28

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