AR110361A1 - Método de preparación de 4-amino-3-cloro-5-fluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo - Google Patents

Método de preparación de 4-amino-3-cloro-5-fluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo

Info

Publication number
AR110361A1
AR110361A1 ARP170103492A ARP170103492A AR110361A1 AR 110361 A1 AR110361 A1 AR 110361A1 AR P170103492 A ARP170103492 A AR P170103492A AR P170103492 A ARP170103492 A AR P170103492A AR 110361 A1 AR110361 A1 AR 110361A1
Authority
AR
Argentina
Prior art keywords
fluoro
chloro
formula
compound
picolinate
Prior art date
Application number
ARP170103492A
Other languages
English (en)
Inventor
Ronald B Leng
Brian Murdoch
Megan E Donaldson
Abraham D Schuitman
David J Couling
Jason S Fisk
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR110361A1 publication Critical patent/AR110361A1/es

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/127—Preparation from compounds containing pyridine rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se describe un método para preparar 4-amino-3-cloro-5-fluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo (1) a partir de 4,5-difluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo (2). El método incluye el uso de etapas de proceso de aminación y cloración para proporcionar el compuesto (1). Reivindicación 1: Un método para preparar el compuesto de fórmula (1) que comprende las etapas de: a) combinar un compuesto de fórmula (2) y amoníaco anhidro; b) aislar un compuesto de fórmula (3) de la combinación de la etapa a); c) combinar el compuesto aislado de fórmula (3) de la etapa b) con HCl anhidro para formar una sal de HCl de fórmula (4); d) aislar el compuesto de fórmula (4) de la etapa c) y combinar el compuesto aislado de fórmula (4) con una base para reformar el compuesto de fórmula (3); e) agregar un agente clorante a la combinación de la etapa d); y f) aislar el compuesto de fórmula (1).
ARP170103492A 2016-12-13 2017-12-13 Método de preparación de 4-amino-3-cloro-5-fluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo AR110361A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662433415P 2016-12-13 2016-12-13

Publications (1)

Publication Number Publication Date
AR110361A1 true AR110361A1 (es) 2019-03-20

Family

ID=62488637

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103492A AR110361A1 (es) 2016-12-13 2017-12-13 Método de preparación de 4-amino-3-cloro-5-fluoro-6-(4-cloro-2-fluoro-3-metoxifenil)picolinato de bencilo

Country Status (12)

Country Link
US (1) US10407391B2 (es)
EP (1) EP3555049A4 (es)
JP (1) JP7129419B2 (es)
KR (1) KR102533388B1 (es)
CN (1) CN110461819A (es)
AR (1) AR110361A1 (es)
AU (1) AU2017378044B2 (es)
BR (1) BR112019011819B1 (es)
CA (1) CA3046650A1 (es)
IL (1) IL267030B2 (es)
TW (1) TWI753978B (es)
WO (1) WO2018111639A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742060A (en) * 1969-11-24 1973-06-26 Gulf Research Development Co Preparation of amines
US3799935A (en) * 1972-10-10 1974-03-26 Dow Chemical Co Substituted aminohalo-pyridines
US4096185A (en) * 1976-01-08 1978-06-20 E. I. Du Pont De Nemours And Company Preparation of p-aminobenzotrifluoride
US20060035954A1 (en) * 2004-08-11 2006-02-16 Sharma Padam N Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
JP5062978B2 (ja) 2005-08-30 2012-10-31 旭化成ケミカルズ株式会社 無機物膜の製造方法
WO2007044490A2 (en) * 2005-10-06 2007-04-19 Boehringer Ingelheim International Gmbh Process for making heteroaryl amine intermediate compounds
US20070185346A1 (en) * 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
US8212047B2 (en) * 2007-09-20 2012-07-03 Exxonmobil Chemical Patents Inc. Methods for preparation of pyridylamines
TWI529163B (zh) * 2011-01-25 2016-04-11 陶氏農業科學公司 用於製備４－胺基－５－氟－３－鹵素－６－（經取代之）吡啶甲酸酯的方法
AR091856A1 (es) * 2012-07-24 2015-03-04 Dow Agrosciences Llc Proceso para la preparacion de 4-amino-5-fluor-3-halo-6-(substituido) picolinatos

Also Published As

Publication number Publication date
KR102533388B1 (ko) 2023-05-19
JP7129419B2 (ja) 2022-09-01
WO2018111639A1 (en) 2018-06-21
JP2020502266A (ja) 2020-01-23
KR20190092434A (ko) 2019-08-07
BR112019011819A2 (pt) 2019-10-29
CA3046650A1 (en) 2018-06-21
IL267030A (en) 2019-07-31
TWI753978B (zh) 2022-02-01
CN110461819A (zh) 2019-11-15
AU2017378044B2 (en) 2021-10-21
US20180162814A1 (en) 2018-06-14
IL267030B1 (en) 2023-07-01
US10407391B2 (en) 2019-09-10
IL267030B2 (en) 2023-11-01
EP3555049A4 (en) 2020-04-29
AU2017378044A1 (en) 2019-07-04
TW201823210A (zh) 2018-07-01
BR112019011819B1 (pt) 2022-12-27
EP3555049A1 (en) 2019-10-23

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