AR102105A1 - Conjugado radiofarmacéutico - Google Patents

Conjugado radiofarmacéutico

Info

Publication number
AR102105A1
AR102105A1 ARP150103118A ARP150103118A AR102105A1 AR 102105 A1 AR102105 A1 AR 102105A1 AR P150103118 A ARP150103118 A AR P150103118A AR P150103118 A ARP150103118 A AR P150103118A AR 102105 A1 AR102105 A1 AR 102105A1
Authority
AR
Argentina
Prior art keywords
linked
radiopharmaceutical
radionuclide
metabolite
vitro
Prior art date
Application number
ARP150103118A
Other languages
English (en)
Original Assignee
The South African Nuclear Energy Corp Ltd
Univ Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The South African Nuclear Energy Corp Ltd, Univ Cape Town filed Critical The South African Nuclear Energy Corp Ltd
Publication of AR102105A1 publication Critical patent/AR102105A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Conjugados radiofarmacéuticos para el uso en métodos mejorados de diagnóstico y tratamiento de cáncer. El conjugado radiofarmacéutico comprende, en secuencia: un metabolito que se dirige a células tumorales, ligado a un agente quelante capaz de contener un radionúclido, ligado a un conector capaz de la unión con un agente EPR in vitro o in vivo; o un agente quelante capaz de contener un radionúclido, ligado a un metabolito que se dirige a células tumorales, ligado a un conector capaz de la unión con un agente EPR in vitro o in vivo. Los conjugados radiofarmacéuticos de la presente proporcionan sistemas de suministro de radionúclidos dirigidos activos y pasivos que pueden ayudar a mejorar la biodistribución y la toxicidad farmacológica de los radiofarmacéuticos usados para el diagnóstico y la terapia de cáncer.
ARP150103118A 2014-09-26 2015-09-28 Conjugado radiofarmacéutico AR102105A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1417067.4A GB201417067D0 (en) 2014-09-26 2014-09-26 Radiopharmaceutical conjugate

Publications (1)

Publication Number Publication Date
AR102105A1 true AR102105A1 (es) 2017-02-01

Family

ID=51901213

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103118A AR102105A1 (es) 2014-09-26 2015-09-28 Conjugado radiofarmacéutico

Country Status (14)

Country Link
US (1) US10874753B2 (es)
EP (1) EP3197504A2 (es)
JP (1) JP6821558B2 (es)
KR (1) KR102276804B1 (es)
CN (1) CN107106709B (es)
AR (1) AR102105A1 (es)
AU (1) AU2015323328B2 (es)
BR (1) BR112017005985A2 (es)
CA (1) CA2962525C (es)
GB (1) GB201417067D0 (es)
MX (1) MX2017003886A (es)
RU (1) RU2017114360A (es)
WO (1) WO2016046793A2 (es)
ZA (1) ZA201702638B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019018536A1 (en) * 2017-07-18 2019-01-24 Vyripharm Enterprises, Llc COMPOSITIONS CONTAINING CONJUGATES OF CANNABINOID ANALOGUES AND METHODS OF USE THEREOF
CN105999308B (zh) * 2016-06-29 2020-08-07 华中科技大学同济医学院附属协和医院 一种肿瘤靶向性mri造影剂及其制备方法
CN106377527B (zh) * 2016-09-05 2019-02-26 郑州大学 开链吡啶羧酸衍生物H2dedpa在抗菌领域的应用
EP3515896A4 (en) 2016-09-19 2020-09-09 The Hong Kong Polytechnic University CHIRAL CYCLE COMPOUNDS AND THEIR USES
AU2018207190B2 (en) * 2017-01-12 2020-12-03 Orano Med Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
RU2019139432A (ru) 2017-05-05 2021-06-07 Сентр фор Проуб Девелопмент энд Коммерсиализэйшн Фармакокинетическая оптимизация бифункциональных хелатов и их применение
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
WO2019125982A1 (en) * 2017-12-18 2019-06-27 Janssen Biotech, Inc. Radiolabeling of polypeptides
MX2018003175A (es) * 2018-03-14 2019-09-16 Instituto Nac De Investigaciones Nucleares 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana.
EP3787696A4 (en) * 2018-04-30 2022-05-18 Bar-Ilan University POLYMERIC CORE-SHELL PARTICLES
US20220040338A1 (en) * 2018-10-16 2022-02-10 Nant Holdings Ip, Llc Alpha Emitter Compositions And Methods
EP4087621A4 (en) * 2020-01-10 2024-01-17 Fusion Pharmaceuticals Inc MACROCYCLIC CHELATES AND USES THEREOF
US20240050600A1 (en) * 2020-08-14 2024-02-15 Clarity Pharmaceuticals Ltd Radiopharmaceuticals, uses thereof, and methods for the production thereof
CN114949267A (zh) * 2021-03-18 2022-08-30 米度（南京）生物技术有限公司 药物缀合物及其应用
US11554184B2 (en) 2021-03-26 2023-01-17 Vyripharm Enterprises, Inc. Synthetic cannabinoid combination therapy compositions and methods for personalized and targeted therapies including the treatment of infectious diseases
WO2022251516A2 (en) * 2021-05-26 2022-12-01 Cornell University Complexes with acyclic chelators and their use in targeted radiotherapy of cancer
WO2023219582A1 (en) * 2022-05-13 2023-11-16 Eczacibaşi Monrol Nükleer Ürünler Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Radiopharmaceuticals with high stability and radiolabeling efficiency and theranostic kit comprising said radiopharmaceuticals

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824659A (en) * 1985-06-07 1989-04-25 Immunomedics, Inc. Antibody conjugates
AU593611B2 (en) 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4699784A (en) * 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
FI923350A (fi) * 1991-07-26 1993-01-27 Hoechst Ag Foerfarande foer maerkning av substanser med teknetium eller renium
WO1994017829A1 (en) * 1993-02-02 1994-08-18 Neorx Corporation Directed biodistribution of small molecules
US20040067196A1 (en) * 2000-10-11 2004-04-08 Brunke Karen J. Targeted therapeutic lipid constructs
EP1610751A4 (en) * 2001-04-26 2006-05-24 Univ Texas AGENTE / LIGAND CONJUGATED THERAPEUTIC COMPOSITIONS, METHODS OF SYNTHESIS AND USE THEREOF
EP1420831A1 (en) * 2001-07-27 2004-05-26 Targesome, Inc. Lipid constructs as therapeutic and imaging agents
EP1583564B1 (en) 2003-01-13 2009-07-01 Bracco Imaging S.p.A Improved linkers for radiopharmaceutical compounds
KR20080072686A (ko) 2005-11-29 2008-08-06 말린크로트, 인코포레이티드 이관능성 금속 킬레이팅 컨쥬게이트
JP2009534309A (ja) 2006-03-31 2009-09-24 マサチューセッツ インスティテュート オブ テクノロジー 治療剤の標的化送達のためのシステム
WO2007121453A2 (en) 2006-04-17 2007-10-25 The Regents Of The University Of California 2-hydroxy-1-oxo 1,2 dihydro isoquinoline chelating agents
KR101653182B1 (ko) 2006-04-19 2016-09-01 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 세포 영상화 및 치료를 위한 조성물 및 방법
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2008134586A1 (en) * 2007-04-27 2008-11-06 The Regents Of The University Of California Site-specific conjugation of ligands to nanoparticles
CN101333259A (zh) * 2008-07-31 2008-12-31 江苏省原子医学研究所 肝受体显像剂99mTc－半乳糖基化人血清白蛋白融合干扰素的制备及其应用
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
BRPI0921586A2 (pt) * 2008-11-18 2019-09-24 Merrimack Pharmaceuticals Inc articuladores de albumina de soro humana e conjugados destes
WO2010062381A1 (en) 2008-11-28 2010-06-03 Robert Shorr Organelle-specific drug delivery
CA2745495C (en) 2008-12-02 2017-07-18 The University Of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
WO2011008996A2 (en) 2009-07-15 2011-01-20 The Regents Of The University Of California Peptides whose uptake in cells is controllable
WO2011008985A2 (en) 2009-07-15 2011-01-20 Georgia Tech Research Corporation Methods and compositions for improved delivery of therapeutic and diagnostic agents
GB201019118D0 (en) 2010-11-11 2010-12-29 King S College Conjugates and their uses in molecular imaging
CN103687624B (zh) * 2011-05-11 2018-02-02 雷蒙特亚特特拉维夫大学有限公司 靶向的聚合缀合物和其用途
PL228735B1 (pl) 2012-02-27 2018-04-30 Inst Immunologii I Terapii Doswiadczalnej Pan Zastosowanie koniugatu składającego się z nośnika i zawiązanego z nim kowalencyjnie leku
TW201511774A (zh) * 2013-09-18 2015-04-01 Iner Aec Executive Yuan 放射性標誌之主動標靶性醫藥組合物及其用途

Also Published As

Publication number Publication date
RU2017114360A (ru) 2018-10-26
KR102276804B1 (ko) 2021-07-15
US20170296684A1 (en) 2017-10-19
RU2017114360A3 (es) 2019-04-04
ZA201702638B (en) 2021-08-25
GB201417067D0 (en) 2014-11-12
WO2016046793A2 (en) 2016-03-31
EP3197504A2 (en) 2017-08-02
KR20170095810A (ko) 2017-08-23
JP2017530131A (ja) 2017-10-12
CN107106709B (zh) 2021-04-06
BR112017005985A2 (pt) 2017-12-19
JP6821558B2 (ja) 2021-01-27
AU2015323328B2 (en) 2021-02-25
CA2962525A1 (en) 2016-03-31
MX2017003886A (es) 2018-01-12
WO2016046793A3 (en) 2016-06-09
CN107106709A (zh) 2017-08-29
CA2962525C (en) 2022-08-30
US10874753B2 (en) 2020-12-29
AU2015323328A1 (en) 2017-05-04

Similar Documents

Publication Publication Date Title
AR102105A1 (es) Conjugado radiofarmacéutico
MX2021008976A (es) Inhibidores marcados de antigeno prostatico especifico de membrama (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata.
CL2019002858A1 (es) Conjugación de un fármaco citotóxico con enlace bis.
MX2021010192A (es) Enlazadores de carbamato de metileno para su uso en conjugados de farmacos dirigidos.
CY1121735T1 (el) 7-benzyλ-10-(2-meθyλobenzyλ)-2,6,7,8,9,10-eξaϋδpoϊmiδazo[1,2-α]πυριδο[4,3-d]πυριμιδιν-5(3η)-ονη για χρηση στην αγωγη του καρκινου
CR20160271A (es) Compuestos peptidométicos y sus conjugados de anticuerpo-fármaco
CU20170172A7 (es) 4,6-diaminoquinolin-3-carbonitrilos sustituidos útiles como agentes analgésicos, antipiréticos o antiinflamatorios y antineoplásicos
MX343405B (es) Complejos que emiten alfa-particulas objetivo que comprenden radionuclido de torio e hidroxipiridinona que contiene ligando.
CL2015003285A1 (es) Arilquinazolinas
MX2019012464A (es) Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl.
MX2017003246A (es) Macropinocitosis de anticuerpos anti-cd46 humanos y agentes terapeuticos dirigidos contra el cancer.
CL2017003307A1 (es) Sistema de administración dirigida de principio activo celular
BR112014030730A2 (pt) entrega de produto radiofarmacêutico e sistema de gerenciamento de tubo
PH12018500701A1 (en) 18f-tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging agents for prostate cancer
BR112013024357A2 (pt) agentes terapêuticos anticancerígenos
AR087330A1 (es) Fago modificado geneticamente y uso del mismo
AR106243A1 (es) Inhibidores mejorados del antígeno prostático específico de membrana marcados con 18f y su uso como agentes para la adquisición de imágenes para el cáncer de próstata
AR084065A1 (es) Compuesto para el tratamiento de tumores y metastasis tumorales
AR098781A1 (es) Compuestos peptidomiméticos y conjugados anticuerpos-droga de los mismos
Funama et al. Volume 2 November 2014
AR110942A1 (es) Composiciones y métodos para terapias de células t con car
SG10201805160UA (en) Methylene carbamate linkers for use with targeted-drug conjugates
EP4212181A3 (en) Methylene carbamate linkers for use with targeted-drug conjugates
UA90286U (uk) Спосіб отримання речовини з потенційними фізіологічними властивостями 1,1'-(2''-бром-2''-хлоретеніл)-біс-(5-метилурацил)
UA87163U (ru) Способ получения вещества с потенциальными физиологическими свойствами 1,1`-(2"-бром-2"-хлорэтенил)-бис-(урацил)

Legal Events

Date Code Title Description
FB Suspension of granting procedure