AR102048A1 - Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furina - Google Patents
Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furinaInfo
- Publication number
- AR102048A1 AR102048A1 ARP150102587A ARP150102587A AR102048A1 AR 102048 A1 AR102048 A1 AR 102048A1 AR P150102587 A ARP150102587 A AR P150102587A AR P150102587 A ARP150102587 A AR P150102587A AR 102048 A1 AR102048 A1 AR 102048A1
- Authority
- AR
- Argentina
- Prior art keywords
- factor
- furina
- secretion
- expression system
- functional
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 108010014173 Factor X Proteins 0.000 abstract 2
- 102000004961 Furin Human genes 0.000 abstract 2
- 108090001126 Furin Proteins 0.000 abstract 2
- 239000012228 culture supernatant Substances 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21075—Furin (3.4.21.75)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462036438P | 2014-08-12 | 2014-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102048A1 true AR102048A1 (es) | 2017-02-01 |
Family
ID=54035298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150102587A AR102048A1 (es) | 2014-08-12 | 2015-08-11 | Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9873892B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3180427B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6793114B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107002041B (cg-RX-API-DMAC7.html) |
| AR (1) | AR102048A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015301726B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2958056C (cg-RX-API-DMAC7.html) |
| EA (1) | EA035444B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2742724T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL250530B (cg-RX-API-DMAC7.html) |
| MX (1) | MX377236B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ729729A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI666319B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016025615A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| US11299533B2 (en) | 2017-06-23 | 2022-04-12 | Takeda Pharmaceutical Company Limited | Purification of factor VIII subspecies |
| WO2020257942A1 (en) * | 2019-06-28 | 2020-12-30 | Peel Sean A F | A method for increasing yields and the specific activity of certain recombinant proteins in mammalian cells by co-expressing full-length furin |
| GB202018320D0 (en) * | 2020-11-20 | 2021-01-06 | Univ Newcastle | Methods of producing recombinant complement proteins |
| WO2023141754A1 (zh) * | 2022-01-25 | 2023-08-03 | 青岛万明赛伯药业有限公司 | proNGF突变体及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0574402B2 (en) | 1990-11-26 | 2012-08-01 | Genetics Institute, LLC | Expression of pace in host cells and methods of use thereof |
| AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| JPH09295945A (ja) * | 1996-04-30 | 1997-11-18 | Hoechst Yakuhin Kogyo Kk | 成熟型骨誘導因子の製造方法 |
| US5876923A (en) | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
| AU784195B2 (en) | 1999-11-12 | 2006-02-16 | Baxter Biotech Technology S.A.R.L. | Reduced side-effect hemoglobin compositions |
| US6596526B1 (en) * | 2000-06-09 | 2003-07-22 | Baxter Aktiengesellschaft | Furin polypeptides with improved characteristics |
| US7223390B2 (en) * | 2003-05-09 | 2007-05-29 | Research Development Foundation | Insertion of furin protease cleavage sites in membrane proteins and uses thereof |
| EP1969127B8 (en) * | 2005-12-21 | 2017-12-13 | Aptevo BioTherapeutics LLC | Method of producing biologically active vitamin k dependent proteins by recombinant methods |
| KR101156263B1 (ko) | 2007-05-18 | 2012-06-13 | 박스터 헬쓰케어 에스.에이. | 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 |
| WO2009088713A1 (en) * | 2007-12-31 | 2009-07-16 | Baxter International Inc. | Substantially animal protein-free recombinant furin and methods for producing same |
| JP5843357B2 (ja) | 2009-02-03 | 2016-01-13 | アムニクス オペレーティング インコーポレイテッド | 延長組換えポリペプチドおよび延長組換えポリペプチドを含む組成物 |
| CA2837948C (en) | 2011-06-02 | 2018-08-21 | Baxter International Inc. | Formulations of recombinant furin |
-
2015
- 2015-08-11 AR ARP150102587A patent/AR102048A1/es unknown
- 2015-08-11 TW TW104126066A patent/TWI666319B/zh active
- 2015-08-12 MX MX2017001931A patent/MX377236B/es active IP Right Grant
- 2015-08-12 NZ NZ729729A patent/NZ729729A/en unknown
- 2015-08-12 CN CN201580055246.1A patent/CN107002041B/zh active Active
- 2015-08-12 AU AU2015301726A patent/AU2015301726B2/en active Active
- 2015-08-12 EA EA201790360A patent/EA035444B1/ru not_active IP Right Cessation
- 2015-08-12 JP JP2017507848A patent/JP6793114B2/ja active Active
- 2015-08-12 US US14/824,927 patent/US9873892B2/en active Active
- 2015-08-12 CA CA2958056A patent/CA2958056C/en active Active
- 2015-08-12 EP EP15757369.2A patent/EP3180427B1/en active Active
- 2015-08-12 WO PCT/US2015/044883 patent/WO2016025615A1/en not_active Ceased
- 2015-08-12 ES ES15757369T patent/ES2742724T3/es active Active
-
2017
- 2017-02-09 IL IL250530A patent/IL250530B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN107002041B (zh) | 2021-06-29 |
| AU2015301726A1 (en) | 2017-03-16 |
| EA035444B1 (ru) | 2020-06-17 |
| US9873892B2 (en) | 2018-01-23 |
| JP2017524366A (ja) | 2017-08-31 |
| MX377236B (es) | 2025-03-07 |
| EP3180427A1 (en) | 2017-06-21 |
| CA2958056A1 (en) | 2016-02-18 |
| NZ729729A (en) | 2023-07-28 |
| MX2017001931A (es) | 2017-06-30 |
| CN107002041A (zh) | 2017-08-01 |
| IL250530B (en) | 2020-03-31 |
| EP3180427B1 (en) | 2019-05-22 |
| IL250530A0 (en) | 2017-03-30 |
| WO2016025615A1 (en) | 2016-02-18 |
| TW201625791A (zh) | 2016-07-16 |
| US20160046957A1 (en) | 2016-02-18 |
| TWI666319B (zh) | 2019-07-21 |
| CA2958056C (en) | 2023-07-04 |
| EA201790360A1 (ru) | 2017-06-30 |
| AU2015301726B2 (en) | 2021-10-21 |
| ES2742724T3 (es) | 2020-02-17 |
| JP6793114B2 (ja) | 2020-12-09 |
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