AR099895A1 - Compuestos heterocíclicos como agentes para combatir parásitos - Google Patents

Compuestos heterocíclicos como agentes para combatir parásitos

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Publication number
AR099895A1
AR099895A1 ARP150100956A ARP150100956A AR099895A1 AR 099895 A1 AR099895 A1 AR 099895A1 AR P150100956 A ARP150100956 A AR P150100956A AR P150100956 A ARP150100956 A AR P150100956A AR 099895 A1 AR099895 A1 AR 099895A1
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Argentina
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alkyl
alkylamino
cyano
series
amino
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ARP150100956A
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English (en)
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Dr Greul Jrg
Dr Schwarz Hans
Georg - Dr Trautwein Axel
Grgens Ulrich
Dr Portz Daniela
Dr Ilg Kerstin
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Bayer Cropscience Ag
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente solicitud se refiere a compuestos heterocíclicos, a su uso para combatir parásitos animales, y vegetales, en las que se incluyen artrópodos, insectos y nematodos. Reivindicación 1: Compuestos de la fórmula (1) en la que A representa un resto de la serie del grupo de fórmulas (2) en la que la línea discontinua significa la unión con Q y en la que A además porta m sustituyentes R²; Q representa un resto de la serie de fórmula (3) en la que el nitrógeno está enlazado con el anillo A y la flecha en cada caso significa la unión con D; y D representa el resto de la fórmula (4) en la que el nitrógeno está unido con Q y la flecha significa la unión con B; B representa un resto de la serie del grupo de fórmulas (5) en la que la línea discontinua significa la unión con D y en la que B además porta n sustituyentes R⁷; Z representa oxigeno o azufre; R¹ representa un resto de la serie halógeno, ciano, nitro, amino, hidroxi ,representa alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, alqueniloxi C₃₋₆, alquiniloxi C₃₋₆, cicloalquiloxi C₃₋₆, alquilcarboniloxi C₁₋₆, alquenilcarboniloxi C₂₋₆, alquinilcarboniloxi C₂₋₆, cicloalquilcarboniloxi C₃₋₆, alcoxicarboniloxi C₁₋₆, alquilsulfoniloxi C₁₋₆,alquilamino C₁₋₆, alquenilamino C₃₋₆, alquinilamino C₃₋₆,cicloalquilamino C₃₋₆, alquilcarbonilamino C₁₋₆, alquenilcarbonilamino C₂₋₆, alquinilcarbonilamino C₂₋₆, cicloalquilcarbonilamino C₃₋₆, alcoxicarbonilamino C₁₋₆, alquilsulfonilamino C₁₋₆, alquiltio C₁₋₆, alqueniltio C₃₋₆, alquiniltio C₃₋₆, cicloalquiltio C₃₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, alquilcarbonilo C₁₋₆, alcoxiimino C₁₋₆-alquilo C₁₋₆, alcoxicarbonilo C₁₋₆, aminocarbonilo, alquilaminocarbonilo C₁₋₆, di-alquilaminocarbonilo C₁₋₆, aminotiocarbonilo, alquilaminosulfonilo C₁₋₆, alquilsulfonilamino C₁₋₆, alquilcarbonilamino C₁₋₆, alquiltiocarbonilamino C₁₋₆, bicicloalquilo C₄₋₁₂, arilo, ariloxi, arilamino, ariltio, heteroarilo, heteroariloxi, heteroarilamino y heteroariltio dado el caso mono- o polisustituidos, de manera igual o diferente, siendo los sustituyentes seleccionados independientemente entre sí de halógeno, ciano, nitro, hidroxi, amino, alquilo C₁₋₆, alcoxi C₁₋₆, cicloalquilo C₃₋₆, haloalcoxi C₁₋₆, alquiltio C₁₋₆, arilo, ariloxi, ariltio, heteroarilo, heteroariloxi y heteroariltio; R² representa un resto de la serie halógeno, ciano, nitro, amino, hidroxi, representa alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, alquenoxi C₃₋₆, alquinoxi C₃₋₆, cicloalcoxi C₃₋₆, alquilcarboniloxi C₁₋₆, alquenilcarboniloxi C₂₋₆, alquinilcarboniloxi C₂₋₆, cicloalquilcarboniloxi C₃₋₆, alcoxicarboniloxi C₁₋₆, alquilsulfoniloxi C₁₋₆, alquilamino C₁₋₆, alquenilamino C₃₋₆, alquinilamino C₃₋₆, cicloalquilamino C₃₋₆, alquilcarbonilamino C₁₋₆, alquenilcarbonilamino C₃₋₆, alquinilcarbonilamino C₂₋₆, cicloalquilcarbonilamino C₃₋₆, alcoxicarbonilamino C₁₋₆, alquilsulfonilamino C₁₋₆, alquiltio C₁₋₆, alqueniltio C₃₋₆, alquiniltio C₃₋₆, cicloalquiltio C₃₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, alquilcarbonilo C₁₋₆, alcoxiimino C₁₋₆-alquilo C₁₋₆, alcoxicarbonilo C₁₋₆, aminocarbonilo, alquilaminocarbonilo C₁₋₆, di-alquilaminocarbonilo C₁₋₆, aminotiocarbonilo, alquilaminosulfonilo C₁₋₆,alquilsulfonilamino C₁₋₆, alquilcarbonilamino C₁₋₆, alquiltiocarbonilamino C₁₋₆, bicicloalquilo C₄₋₁₂, arilo, ariloxi, arilamino, ariltio, heteroarilo, heteroariloxi, heteroarilamino y heteroariltio dado el caso mono- o polisustituidos, de manera igual o diferente, siendo los sustituyentes seleccionados independientemente entre sí de halógeno, ciano, nitro, hidroxi, amino, alquilo C₁₋₆, alcoxi C₁₋₆, cicloalquilo C₃₋₆, haloalcoxi C₁₋₆ y alquiltio C₁₋₆, arilo, ariloxi, ariltio, heteroarilo, heteroariloxi y heteroariltio; R³ representa un resto de la serie hidrógeno, halógeno, ciano, nitro, amino, hidroxi, alquilo C₁₋₆, alcoxi C₁₋₆, alquiltio C₁₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquiltio C₁₋₆, haloalquilsulfinilo C₁₋₆ y haloalquilsulfonilo C₁₋₆; R⁴ representa un resto de la serie hidrógeno, halógeno, ciano, nitro, amino, hidroxi, alquilo C₁₋₆, alcoxi C₁₋₆, haloalquilo C₁₋₆ y haloalcoxi C₁₋₆; R⁵ representa un resto de la serie hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, haloalquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₃₋₆, cicloalquilo C₃₋₆ alquilo C₁₋₆, ciano-alquilo C₁₋₆, alquilcarbonilo C₁₋₆, alquenilcarbonilo C₂₋₆, haloalquilcarbonilo C₁₋₆, haloalquenilcarbonilo C₂₋₆, alcoxi C₁₋₆-alquilo C₁₋₆, alcoxicarbonilo C₁₋₆, alquilsulfonilo C₁₋₆ y haloalquilsulfonilo C₁₋₆ o representa C(=O)-B; R⁶ representa un resto de la serie halógeno, ciano, nitro, amino, hidroxi, representa alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₆ alcoxi C₁₋₆, alqueniloxi C₃₋₆, alquiniloxi C₃₋₆, cicloalcoxi C₃₋₆, alquilcarboniloxi C₁₋₆, alquenilcarboniloxi C₂₋₆, alquinilcarboniloxi C₂₋₆, cicloalquilo C₃₋₆-carboniloxi, alcoxicarboniloxi C₁₋₆, alquilsulfoniloxi C₁₋₆ alquilamino C₁₋₆, alquenilamino C₂₋₆, alquinilamino C₂₋₆, cicloalquilamino C₃₋₆, alcoxicarbonilamino C₁₋₆, alquilsulfonilamino C₁₋₆, alquiltio C₁₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, alquilcarbonilo C₁₋₆, alcoxiimino C₁₋₆-alquilo C₁₋₆, alcoxicarbonilo C₁₋₆, aminocarbonilo, alquilaminocarbonilo C₁₋₆, di-alquilaminocarbonilo C₁₋₆, aminotiocarbonilo, alquilaminosulfonilo C₁₋₆, alquilsulfonilamino C₁₋₆, alquilcarbonilamino C₁₋₆, alquiltio C₁₋₆-carbonilamino, bicicloalquilo C₄₋₁₂, arilo, heteroarilo dado el caso mono- o polisustituidos, de manera igual o diferente, siendo los sustituyentes seleccionados independientemente entre sí de halógeno, ciano, nitro, hidroxi, amino, alquilo C₁₋₆, alcoxi C₁₋₆, cicloalquilo C₃₋₆, haloalcoxi C₁₋₆ y alquiltio C₁₋₆; R⁷ representa un resto de la serie halógeno, nitro, ciano, amino, hidroxi, representa alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, alquenoxi C₃₋₆, alquinoxi C₃₋₆, cicloalcoxi C₃₋₆, alquilcarboniloxi C₁₋₆, alquenilcarboniloxi C₂₋₆, alquinilcarboniloxi C₂₋₆, cicloalquilcarboniloxi C₃₋₆, alcoxicarboniloxi C₁₋₆, alquilsulfoniloxi C₁₋₆, alquilamino C₁₋₆, alquenilamino C₂₋₆, alquinilamino C₂₋₆, cicloalquilamino C₃₋₆, alcoxicarbonilamino C₁₋₆, alquilsulfonilamino C₁₋₆, alquiltio C₁₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, alquilcarbonilo C₁₋₆, alcoxiimino C₁₋₆-alquilo C₁₋₆, alcoxicarbonilo C₁₋₆, aminocarbonilo, alquilaminocarbonilo C₁₋₆, di-alquilaminocarbonilo C₁₋₆, aminotiocarbonilo, alquilaminosulfonilo C₁₋₆, alquilsulfonilamino C₁₋₆, alquilcarbonilamino C₁₋₆, alquiltio C₁₋₆-carbonilamino, bicicloalquilo C₄₋₁₂, arilo, ariloxi, ariltio, heteroarilo, heteroariloxi y heteroariltio dado el caso mono- o polisustituidos, de manera igual o diferente, siendo los sustituyentes seleccionados independientemente entre sí de halógeno, ciano, nitro, hidroxi, amino, alquilo C₁₋₆, alcoxi C₁₋₆, cicloalquilo C₃₋₆, haloalcoxi C₁₋₆ y alquiltio C₁₋₆; m representa un número de la serie 0, 1, 2, 3 y 4, pudiendo ser para m > 1 los restos R² iguales o diferentes y n representa un número de la serie 0, 1, 2 y 3, pudiendo ser para n > 1 los restos R⁷ iguales o diferentes; estando exceptuados los compuestos de las fórmulas del grupo de fórmulas (6).
ARP150100956A 2014-04-02 2015-03-30 Compuestos heterocíclicos como agentes para combatir parásitos AR099895A1 (es)

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EP (1) EP3126335B1 (es)
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AR (1) AR099895A1 (es)
BR (1) BR112016022688B1 (es)
ES (1) ES2819505T3 (es)
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AR102315A1 (es) * 2014-04-02 2017-02-22 Bayer Cropscience Ag Derivados de pirazolil-nicotin(tio)amida sustituidos y su uso como fungicidas

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BR112016022688B1 (pt) 2021-09-08
JP2017511336A (ja) 2017-04-20
TW201623247A (zh) 2016-07-01
US20170022168A1 (en) 2017-01-26
BR112016022688A2 (pt) 2017-10-17
EP3126335A1 (de) 2017-02-08
ES2819505T3 (es) 2021-04-16
EP3126335B1 (de) 2020-07-08
JP6434048B2 (ja) 2018-12-05
WO2015150300A1 (de) 2015-10-08

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