AR092409A1 - Formas cristalinas de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3h-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona - Google Patents

Formas cristalinas de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3h-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona

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Publication number
AR092409A1
AR092409A1 ARP130103110A ARP130103110A AR092409A1 AR 092409 A1 AR092409 A1 AR 092409A1 AR P130103110 A ARP130103110 A AR P130103110A AR P130103110 A ARP130103110 A AR P130103110A AR 092409 A1 AR092409 A1 AR 092409A1
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Argentina
Prior art keywords
approximately
degrees
ray diffraction
diffraction pattern
dihydroisoxazol
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ARP130103110A
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English (en)
Inventor
Joseph Birchmeier Matthew
Billen Denis
J Vanderroest Ronald
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Zoetis Llc
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Publication date
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Publication of AR092409A1 publication Critical patent/AR092409A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicación 1: Una forma cristalina A de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3H-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona, caracterizada porque exhibe al menos una de las propiedades siguientes: a) un patrón de difracción de rayos X que tiene picos característicos expresados en grados 2q (± 0,2º) a aproximadamente 17,18, 18,83 y 20,07; b) un patrón de difracción de rayos X que tiene picos característicos expresados en grados 2q (± 0,2º) a aproximadamente 17,18, 18,83 y 20,07, y que además comprende al menos un pico de difracción adicional expresado en grados 2q (± 0,2º) seleccionado del grupo que consiste en picos de aproximadamente 4,70, 9,39, 14,10, 15,70, 19,12, 20,97, 21;42, 22,03, 22,54, 23,62 y 28,42; c) un patrón de difracción de rayos X que tiene picos característicos expresados en grados 2q (± 0,2º) a aproximadamente 17,18, 18,83 y 20,07, y que además comprende al menos un pico de difracción adicional expresado en grados 2q (± 0,2º) a aproximadamente 21,42, 22,54 y 28,42; d) un patrón de difracción de rayos X que tiene picos característicos expresados en grados 2q (± 0,2º) a aproximadamente 17,18, 18,83, 20,07, 21,42, 22,54 y 28,42; e) un espectro de infrarrojos por transformada de Fourier en el intervalo de 1.800 a 600 cm⁻¹ sustancialmente como se muestra en la Figura 2; f) un termograma de calorimetría diferencial de barrido que tiene una única endotermia predominante a aproximadamente 145,53ºC a una velocidad de barrido de 10ºC por minuto, sustancialmente como se muestra en la Figura 3.1; y g) un termograma de calorimetría diferencial de barrido que tiene una única endotermia predominante en el intervalo de 144,01ºC a 146,92ºC a una velocidad de barrido de 10ºC por minuto, sustancialmente como se muestra en la Figura 3.2.
ARP130103110A 2012-08-31 2013-08-30 Formas cristalinas de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3h-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona AR092409A1 (es)

Applications Claiming Priority (1)

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US201261695410P 2012-08-31 2012-08-31

Publications (1)

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AR092409A1 true AR092409A1 (es) 2015-04-22

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ARP130103110A AR092409A1 (es) 2012-08-31 2013-08-30 Formas cristalinas de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3h-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona

Country Status (29)

Country Link
US (1) US9200003B2 (es)
EP (1) EP2890699B1 (es)
JP (1) JP6109942B2 (es)
KR (1) KR101736643B1 (es)
CN (1) CN104812758B (es)
AR (1) AR092409A1 (es)
AU (1) AU2013308887B2 (es)
BR (1) BR112015004135B8 (es)
CA (1) CA2881467C (es)
CL (1) CL2015000332A1 (es)
CY (1) CY1120611T1 (es)
DK (1) DK2890699T3 (es)
ES (1) ES2671271T3 (es)
HK (1) HK1209125A1 (es)
HR (1) HRP20180861T1 (es)
HU (1) HUE037667T2 (es)
LT (1) LT2890699T (es)
MX (1) MX351463B (es)
NO (1) NO2931268T3 (es)
NZ (1) NZ704175A (es)
PH (1) PH12015500441B1 (es)
PL (1) PL2890699T3 (es)
PT (1) PT2890699T (es)
RS (1) RS57284B1 (es)
RU (1) RU2614978C2 (es)
SI (1) SI2890699T1 (es)
TR (1) TR201807735T4 (es)
WO (1) WO2014036056A1 (es)
ZA (1) ZA201500728B (es)

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SI2890699T1 (en) 2018-07-31
MX351463B (es) 2017-10-16
AU2013308887B2 (en) 2015-11-12
DK2890699T3 (en) 2018-06-14
AU2013308887A1 (en) 2015-02-19
CN104812758B (zh) 2017-05-03
PH12015500441A1 (en) 2015-04-20
PT2890699T (pt) 2018-06-01
PL2890699T3 (pl) 2018-10-31
KR101736643B1 (ko) 2017-05-16
MX2015002679A (es) 2015-05-12
HUE037667T2 (hu) 2018-09-28
ES2671271T3 (es) 2018-06-05
BR112015004135B8 (pt) 2022-11-22
US9200003B2 (en) 2015-12-01
EP2890699B1 (en) 2018-04-11
RS57284B1 (sr) 2018-08-31
TR201807735T4 (tr) 2018-06-21
EP2890699A1 (en) 2015-07-08
WO2014036056A1 (en) 2014-03-06
CN104812758A (zh) 2015-07-29
CA2881467A1 (en) 2014-03-06
LT2890699T (lt) 2018-06-25
US20150183795A1 (en) 2015-07-02
BR112015004135B1 (pt) 2020-12-08
CA2881467C (en) 2017-08-29
PH12015500441B1 (en) 2015-04-20
RU2614978C2 (ru) 2017-03-31
ZA201500728B (en) 2016-08-31
NZ704175A (en) 2015-10-30
JP2015526522A (ja) 2015-09-10
HRP20180861T1 (hr) 2018-07-13
NO2931268T3 (es) 2018-04-21
KR20150038366A (ko) 2015-04-08
CL2015000332A1 (es) 2015-05-15
BR112015004135A2 (pt) 2017-07-04
JP6109942B2 (ja) 2017-04-05
RU2015107052A (ru) 2016-10-20
CY1120611T1 (el) 2019-12-11
HK1209125A1 (en) 2016-03-24

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