AR092377A1 - Vacuna capaz de inducir la formacion de anticuerpos dirigidos contra pcsk9 - Google Patents
Vacuna capaz de inducir la formacion de anticuerpos dirigidos contra pcsk9Info
- Publication number
- AR092377A1 AR092377A1 ARP130103067A ARP130103067A AR092377A1 AR 092377 A1 AR092377 A1 AR 092377A1 AR P130103067 A ARP130103067 A AR P130103067A AR P130103067 A ARP130103067 A AR P130103067A AR 092377 A1 AR092377 A1 AR 092377A1
- Authority
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- Argentina
- Prior art keywords
- amino acid
- group
- acid residue
- alanine
- valine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 title abstract 2
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 23
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 11
- 235000004279 alanine Nutrition 0.000 abstract 11
- 229960003767 alanine Drugs 0.000 abstract 11
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 6
- 239000004474 valine Substances 0.000 abstract 6
- 235000014393 valine Nutrition 0.000 abstract 6
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 5
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 5
- 239000004473 Threonine Substances 0.000 abstract 5
- 235000008521 threonine Nutrition 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 4
- 235000004554 glutamine Nutrition 0.000 abstract 4
- 235000013930 proline Nutrition 0.000 abstract 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 3
- 235000003704 aspartic acid Nutrition 0.000 abstract 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- 235000006693 Cassia laevigata Nutrition 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
- 241000522641 Senna Species 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 229960000310 isoleucine Drugs 0.000 abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229940124513 senna glycoside Drugs 0.000 abstract 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 239000004472 Lysine Chemical group 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 abstract 1
- UFWLHIVKHDCSHZ-UHFFFAOYSA-N chembl1595789 Chemical compound NC1=NC(N)=NC(C=2C(=CC=CC=2)O)=N1 UFWLHIVKHDCSHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- 229960002743 glutamine Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical group OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 235000008729 phenylalanine Nutrition 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 235000002374 tyrosine Nutrition 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
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Abstract
Vacuna capaz de inducir la formación de anticuerpos dirigidos contra PCSK9 in vivo. Reivindicación 1: Una vacuna que comprende por lo menos un péptido que consiste en 9 a 25 residuos de aminoácidos que tiene la secuencia de aminoácidos X¹X²X³WX⁴X⁵X⁶RX⁷(X⁸)ₘ(X⁹)ₙ (SEC ID Nº 1) donde X¹ es un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, seleccionados, preferentemente, del grupo que consiste en sen, treonina, valina y alanina, X² es un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, preferentemente seleccionados del grupo de isoleucina, valina, glicina, glutamina y alanina, más preferentemente isoleucina, valina, glutamina y alanina, X³ es un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, seleccionados, preferentemente, del grupo que consiste en prolina, treonina, alanina y valina, más preferentemente prolina, X⁴ es un residuo de aminoácido seleccionado del grupo que consiste en asparagina, sen, alanina, glutamina y ácido aspártico, X⁵ es un residuo de aminoácido seleccionado del grupo que consiste en leucina, glicina, alanina, tirosina, ácido aspártico, fenilalanina y valina, preferentemente leucina, X⁶ es un residuo de aminoácido seleccionado del grupo de residuo de aminoácido cargado negativamente, hidrófilo, preferentemente un residuo de aminoácido seleccionado del grupo que consiste en ácido glutámico y ácido aspártico, X⁷ es un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, seleccionados, preferentemente, del grupo que consiste en isoleucina, leucina, alanina y treonina, X⁸ es un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados seleccionado del grupo que consiste en treonina, leucina, glutamina, alanina y serina, X⁹ es X¹⁰X¹¹X¹² o un fragmento truncado de terminal C del mismo que consiste en 1 ó 2 residuos de aminoácidos, X¹⁰ es cualquier residuo de aminoácido, preferentemente un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, seleccionados, preferentemente, del grupo que consiste en prolina, alanina y serina, X¹¹ es cualquier residuo de aminoácido, preferentemente un residuo de aminoácido seleccionado del grupo de residuos de aminoácidos no cargados, seleccionados, preferentemente, del grupo que consiste en prolina, alanina, valina, treonina y asparagina, X¹² es cualquier residuo de aminoácido, preferentemente un residuo de aminoácido seleccionado del grupo que consiste en arginina, alanina, lisina, serina y leucina, m es 0 ó 1, n es 0 ó 1, y SEC ID Nº 1 no es SIPWNLERITPPR o un fragmento truncado de terminal C del mismo, donde dicho por lo menos un péptido es acoplado o fusionado a un portador farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12182241.5A EP2703483A1 (en) | 2012-08-29 | 2012-08-29 | PCSK9 peptide vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092377A1 true AR092377A1 (es) | 2015-04-15 |
Family
ID=46785271
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103067A AR092377A1 (es) | 2012-08-29 | 2013-08-29 | Vacuna capaz de inducir la formacion de anticuerpos dirigidos contra pcsk9 |
| ARP230100224A AR128395A2 (es) | 2012-08-29 | 2023-01-31 | Péptidos novedosos capaces de inducir la formación de anticuerpos contra pcsk9 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230100224A AR128395A2 (es) | 2012-08-29 | 2023-01-31 | Péptidos novedosos capaces de inducir la formación de anticuerpos contra pcsk9 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US9533030B2 (es) |
| EP (3) | EP2703483A1 (es) |
| JP (2) | JP6298820B2 (es) |
| KR (1) | KR102101201B1 (es) |
| CN (2) | CN104685053B (es) |
| AR (2) | AR092377A1 (es) |
| AU (2) | AU2013307319B2 (es) |
| CA (1) | CA2881318C (es) |
| CY (1) | CY1121067T1 (es) |
| DK (1) | DK2890785T3 (es) |
| ES (1) | ES2693572T3 (es) |
| HK (1) | HK1249859A1 (es) |
| HR (1) | HRP20181782T2 (es) |
| HU (1) | HUE040469T2 (es) |
| LT (1) | LT2890785T (es) |
| PL (1) | PL2890785T3 (es) |
| PT (1) | PT2890785T (es) |
| SI (1) | SI2890785T1 (es) |
| TR (1) | TR201815497T4 (es) |
| TW (1) | TWI615148B (es) |
| WO (1) | WO2014033158A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2703483A1 (en) * | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| CA3003943A1 (en) | 2015-11-03 | 2017-05-11 | Affiris Ag | Method for vaccination against a self-antigen in a human patient |
| CN106822881A (zh) * | 2016-12-09 | 2017-06-13 | 四川大学 | 一种针对pcsk9的抗高血脂蛋白疫苗 |
| WO2018189705A1 (en) | 2017-04-13 | 2018-10-18 | Cadila Healthcare Limited | Novel peptide based pcsk9 vaccine |
| CN114672476A (zh) * | 2022-01-14 | 2022-06-28 | 复旦大学附属中山医院 | 人pcsk9蛋白的优势构象表位及其应用 |
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-
2012
- 2012-08-29 EP EP12182241.5A patent/EP2703483A1/en not_active Withdrawn
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2013
- 2013-08-26 TW TW102130502A patent/TWI615148B/zh active
- 2013-08-28 CN CN201380040051.0A patent/CN104685053B/zh active Active
- 2013-08-28 HR HRP20181782TT patent/HRP20181782T2/hr unknown
- 2013-08-28 AU AU2013307319A patent/AU2013307319B2/en active Active
- 2013-08-28 LT LTEP13756108.0T patent/LT2890785T/lt unknown
- 2013-08-28 CA CA2881318A patent/CA2881318C/en active Active
- 2013-08-28 PT PT13756108T patent/PT2890785T/pt unknown
- 2013-08-28 DK DK13756108.0T patent/DK2890785T3/en active
- 2013-08-28 EP EP13756108.0A patent/EP2890785B1/en active Active
- 2013-08-28 EP EP18179778.8A patent/EP3409770A3/en active Pending
- 2013-08-28 KR KR1020157008006A patent/KR102101201B1/ko active IP Right Grant
- 2013-08-28 TR TR2018/15497T patent/TR201815497T4/tr unknown
- 2013-08-28 ES ES13756108.0T patent/ES2693572T3/es active Active
- 2013-08-28 SI SI201331240T patent/SI2890785T1/sl unknown
- 2013-08-28 US US14/418,139 patent/US9533030B2/en active Active
- 2013-08-28 PL PL13756108T patent/PL2890785T3/pl unknown
- 2013-08-28 WO PCT/EP2013/067797 patent/WO2014033158A2/en active Application Filing
- 2013-08-28 HU HUE13756108A patent/HUE040469T2/hu unknown
- 2013-08-28 CN CN201711057619.6A patent/CN107837392A/zh active Pending
- 2013-08-28 JP JP2015529001A patent/JP6298820B2/ja active Active
- 2013-08-29 AR ARP130103067A patent/AR092377A1/es not_active Application Discontinuation
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2016
- 2016-12-02 US US15/367,711 patent/US9999659B2/en active Active
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2017
- 2017-10-25 JP JP2017206158A patent/JP2018048177A/ja active Pending
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2018
- 2018-05-21 US US15/984,800 patent/US10933123B2/en active Active
- 2018-07-19 HK HK18109348.0A patent/HK1249859A1/zh unknown
- 2018-11-05 CY CY181101153T patent/CY1121067T1/el unknown
- 2018-12-13 AU AU2018278933A patent/AU2018278933A1/en not_active Abandoned
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2021
- 2021-01-11 US US17/145,571 patent/US11980657B2/en active Active
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2023
- 2023-01-31 AR ARP230100224A patent/AR128395A2/es unknown
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2024
- 2024-02-28 US US18/589,494 patent/US20240197844A1/en active Pending
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