AR084725A1 - Composiciones bioactivas de chromobacterium y metabolitos - Google Patents

Composiciones bioactivas de chromobacterium y metabolitos

Info

Publication number
AR084725A1
AR084725A1 ARP110103917A ARP110103917A AR084725A1 AR 084725 A1 AR084725 A1 AR 084725A1 AR P110103917 A ARP110103917 A AR P110103917A AR P110103917 A ARP110103917 A AR P110103917A AR 084725 A1 AR084725 A1 AR 084725A1
Authority
AR
Argentina
Prior art keywords
ch3cn
compounds
chromobacterium
approximately
liquid chromatography
Prior art date
Application number
ARP110103917A
Other languages
English (en)
Inventor
Ratnakar Asolkar
Pamela MARRONE
Marja Koivunen
Huazhang Huang
Original Assignee
Marrone Bio Innovations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45973220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR084725(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Marrone Bio Innovations Inc filed Critical Marrone Bio Innovations Inc
Publication of AR084725A1 publication Critical patent/AR084725A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a compuestos bioactivos y metabolitos derivados de cultivos de especies de Chromobacterium responsables de controlar plagas, composiciones que contienen estos compuestos, métodos para obtener estos compuestos y métodos para usar estos compuestos y composiciones para controlar plagas.Reivindicación 1: Un compuesto caracterizado porque (a) tiene actividad pesticida; (b) tiene un peso molecular de aproximadamente 840 - 900 como se determina por Cromatografía Líquida/Espectroscopia de Masas (LC/MS); y (c) tiene una Cromatografía Líquida de Alta Presión (HPLC) tiempo de retención de aproximadamente 7 - 12 minutos en una columna HPLC C-18 de fase inversa usando un sistema de solvente de gradiente agua:acetonitrilo (CH3CN) (0 - 20 min.; 90 - 0% CH3CN acuoso, 20 - 24 min.; 100% CH3CN, 24 - 27 min.; 0 - 90% CH3CN acuoso, 27 - 30 min.; 90% CH3CN acuoso) a 0.5 mL/mm. velocidad de flujo y detección UV de 210 nm; y (d) se obtiene opcionalmente de especies de Chromobacterium.
ARP110103917A 2010-10-25 2011-10-21 Composiciones bioactivas de chromobacterium y metabolitos AR084725A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40656910P 2010-10-25 2010-10-25

Publications (1)

Publication Number Publication Date
AR084725A1 true AR084725A1 (es) 2013-06-05

Family

ID=45973220

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103917A AR084725A1 (es) 2010-10-25 2011-10-21 Composiciones bioactivas de chromobacterium y metabolitos

Country Status (26)

Country Link
US (4) US8715754B2 (es)
EP (1) EP2632272B1 (es)
JP (2) JP5897585B2 (es)
KR (1) KR101875591B1 (es)
CN (2) CN103179862B (es)
AR (1) AR084725A1 (es)
AU (1) AU2011323828B8 (es)
BR (1) BR112013009862B1 (es)
CA (1) CA2815789C (es)
CL (1) CL2013001133A1 (es)
CO (1) CO6731075A2 (es)
CR (1) CR20130184A (es)
EC (1) ECSP13012590A (es)
ES (1) ES2746551T3 (es)
HU (1) HUE046098T2 (es)
IL (1) IL225810A (es)
MA (1) MA34676B1 (es)
MX (1) MX343738B (es)
NZ (2) NZ609123A (es)
PE (1) PE20140254A1 (es)
PL (1) PL2632272T3 (es)
PT (1) PT2632272T (es)
RU (1) RU2580105C2 (es)
TW (1) TW201225844A (es)
WO (1) WO2012061082A2 (es)
ZA (2) ZA201303570B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951585B2 (en) 2010-02-25 2015-02-10 Marrone Bio Innovations, Inc. Compositions and methods for modulating plant parasitic nematodes
AR080234A1 (es) * 2010-02-25 2012-03-21 Marrone Bio Innovations Inc Cepa bacteriana aislada del genero burkholderia y metabolitos pesticidas del mismo
NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
TW201225844A (en) 2010-10-25 2012-07-01 Marrone Bio Innovations Inc Chromobacterium bioactive compositions and metabolites
ES2689558T3 (es) * 2011-10-25 2018-11-14 Marrone Bio Innovations, Inc. Formulaciones, composiciones y metabolitos de Chromobacterium y sus usos
US10334856B2 (en) 2012-05-29 2019-07-02 Neozyme International, Inc. Non-toxic pest control compositions and methods and uses thereof
PT3659982T (pt) 2012-05-29 2020-11-13 Neozyme Inernational Inc Uma composição bio catalítica útil no condicionamento do solo
US10681914B2 (en) 2012-05-29 2020-06-16 Neozyme International, Inc. Non-toxic plant agent compositions and methods and uses thereof
US10557234B2 (en) 2012-05-29 2020-02-11 Neozyme International, Inc. Papermaking additive compositions and methods and uses thereof
US9125419B2 (en) * 2012-08-14 2015-09-08 Marrone Bio Innovations, Inc. Bacillus sp. strain with antifungal, antibacterial and growth promotion activity
JP6002567B2 (ja) * 2012-12-18 2016-10-05 学校法人東海大学 試料前処理方法
US8808719B1 (en) 2013-03-15 2014-08-19 Marrone Bio Innovations, Inc. Use of Chromobacterium substugae formulations, compostions and compounds to modulate cornworm rootworm larvae infestation
WO2015077278A1 (en) * 2013-11-20 2015-05-28 Novozymes Bioag A/S Compositions and methods comprising chromobacterium for controlling plant nematode pests and plant insect pests
US20170188581A1 (en) * 2014-03-27 2017-07-06 Bayer Cropscience Aktiengesellschaft Insecticidal and nematocidal active ingredient combinations
WO2016033396A1 (en) 2014-08-28 2016-03-03 The Johns Hopkins University Compositions and methods useful for the prevention of malaria and dengue virus transmission
CA2957302C (en) * 2014-09-05 2023-07-25 Marrone Bio Innovations, Inc. Chromobacterium subtsugae genes with insecticidal activity
EP3191594A4 (en) 2014-09-11 2018-06-13 Marrone Bio Innovations, Inc. Chromobacterium subtsugae genome
WO2016057203A1 (en) * 2014-10-06 2016-04-14 Marrone Bio Innovations, Inc. Granule formulations as biochemical agricultural products
AU2016311181C1 (en) * 2015-08-22 2019-05-02 Neozyme International, Inc. Papermaking additive compositions and methods and uses thereof
WO2018168582A1 (ja) * 2017-03-14 2018-09-20 イビデン株式会社 殺虫剤および殺虫剤の製造方法
CN110643651B (zh) * 2019-09-30 2022-11-04 大连民族大学 一种促进紫色色杆菌中脱氧紫色杆菌素表达的方法
CN111448925A (zh) * 2020-04-08 2020-07-28 赤峰学院 一种用于防治果菜类蔬菜根结线虫病的方法
IL297629A (en) 2020-04-26 2022-12-01 Neozyme Int Inc Dry powder compositions, methods and uses thereof
CN112314284A (zh) * 2020-11-30 2021-02-05 淄博市蔬菜办公室 一种防治设施蔬菜根结线虫病的方法
EP4351343A1 (en) * 2021-05-14 2024-04-17 Pluton Biosciences, Inc. Chryseobacterium insect inhibitory microbial compositions and methods of making and using
CN114606155B (zh) * 2022-01-25 2023-08-04 云南大学 苏云金芽孢杆菌Bt79和/或Bt80菌株在防治植物南方根结线虫中的应用
AR129179A1 (es) * 2022-04-28 2024-07-24 Pro Farm Group Inc Composición insecticida sinérgica y método para modular la infestación de una plaga aplicando la misma
PL244267B1 (pl) 2022-12-09 2023-12-27 Univ Mikolaja Kopernika W Toruniu Sposób wytwarzania folii kefiranowej oraz folia kefiranowa
PL244266B1 (pl) 2022-12-09 2023-12-27 Univ Mikolaja Kopernika W Toruniu Folia kefiranowa oraz sposób jej wytwarzania
CN117247196B (zh) * 2023-11-07 2024-06-28 湖南省核地质调查所 一种去除水中锑离子的方法和系统

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US5047424A (en) 1988-10-03 1991-09-10 Safer, Inc. Environmentally safe insecticide
WO1991000012A1 (en) 1989-06-28 1991-01-10 Imperial Chemical Industries Plc Microbes for controlling pests
JPH06247964A (ja) 1993-02-22 1994-09-06 Snow Brand Milk Prod Co Ltd 新規生理活性物質ｈｓ−１及びその製造方法
FR2729825A1 (fr) 1995-01-30 1996-08-02 Rhone Poulenc Agrochimie Associations insecticides comprenant un insecticide de la famille des chloronicotinyls et un insecticide a groupe pyrazole,pyrrole ou phenylimidazole pour traiter les semences ou le sol
DE19545463A1 (de) * 1995-12-06 1997-06-12 Bayer Ag Organisch-chemische Verbindung und Verfahren zu ihrer Herstellung
JPH10139612A (ja) * 1996-11-15 1998-05-26 Nakanihon Seni Kogyo Kyodo Kumiai 天然抗菌抗酸化剤の製造方法及びこれを配合した化粧品
US6103228A (en) 1997-05-09 2000-08-15 Agraquest, Inc. Compositions and methods for controlling plant pests
US7037494B2 (en) 1997-10-14 2006-05-02 The Board Of Regents Of The University Of Texas System Formulations and methods for insect control
MXPA02009919A (es) 2000-04-04 2004-09-06 Abr Llc Microemulsiones de plaguicida y formulaciones de dispersante/penetrante mejoradas.
WO2001076612A1 (en) * 2000-04-11 2001-10-18 Valent Biosciences, Corp. METHOD FOR PRODUCING NEMATOCIDAL COMPOSITION BY HEAT TREATING A pH-ADJUSTED FERMENTATION BROTH
CU23176A1 (es) * 2001-01-03 2006-09-22 Ct Ingenieria Genetica Biotech Composiciones pesticidas y antiparasitarias
CA2466533A1 (en) * 2003-05-12 2004-11-12 Sumitomo Chemical Company, Limited Method for controlling harmful plant-parasitic nematodes
US7244607B2 (en) 2003-10-01 2007-07-17 The United States Of America, As Represented By The Secretary Of Agriculture Chromobacterium subtsugae sp. nov. for control of insect pests
CN1597930B (zh) * 2004-08-18 2011-02-02 湖北大学 自养黄色杆菌及其杀螺剂
JP3881363B1 (ja) 2005-09-22 2007-02-14 株式会社コナミデジタルエンタテインメント ゲーム装置、ゲーム装置の制御方法及びプログラム
KR100802494B1 (ko) 2006-02-24 2008-02-12 (주)한국바이오케미칼 비올라세인을 함유하는 해충 방제제, 항진균제 및 그의제조방법
EP1849363A1 (en) 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US7825267B2 (en) * 2006-09-08 2010-11-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Synthesis of FR901464 and analogs with antitumor activity
CN101003787A (zh) * 2007-01-09 2007-07-25 东北农业大学 可高效降解长残留除草剂异噁草酮的降解菌及其培养方法
CN101054565A (zh) * 2007-04-10 2007-10-17 南京农业大学 防治温室蔬菜根结线虫病的生防菌株
US20110105333A1 (en) * 2007-08-16 2011-05-05 Rafel Israels Seed Treatment Compositions and Methods
JP5168687B2 (ja) * 2007-12-25 2013-03-21 独立行政法人農業・食品産業技術総合研究機構 ネコブセンチュウによる植物病害を防御する方法
NZ596529A (en) * 2009-04-20 2014-05-30 Marrone Bio Innovations Inc Chemical and biological agents for the control of molluscs
AR080234A1 (es) 2010-02-25 2012-03-21 Marrone Bio Innovations Inc Cepa bacteriana aislada del genero burkholderia y metabolitos pesticidas del mismo
US8883461B2 (en) * 2010-03-12 2014-11-11 Council Of Scientific & Industrial Research Process for the production of violacein and its derivative deoxyviolacein containing bioactive pigment from Chromobacterium sp. (MTCC5522)
TW201225844A (en) 2010-10-25 2012-07-01 Marrone Bio Innovations Inc Chromobacterium bioactive compositions and metabolites
ES2689558T3 (es) 2011-10-25 2018-11-14 Marrone Bio Innovations, Inc. Formulaciones, composiciones y metabolitos de Chromobacterium y sus usos
US8808719B1 (en) 2013-03-15 2014-08-19 Marrone Bio Innovations, Inc. Use of Chromobacterium substugae formulations, compostions and compounds to modulate cornworm rootworm larvae infestation

Also Published As

Publication number Publication date
JP5897585B2 (ja) 2016-03-30
PT2632272T (pt) 2019-10-31
CO6731075A2 (es) 2013-08-15
JP2016147872A (ja) 2016-08-18
JP2013543846A (ja) 2013-12-09
NZ622566A (en) 2015-02-27
TW201225844A (en) 2012-07-01
WO2012061082A3 (en) 2012-08-16
CN105104433A (zh) 2015-12-02
BR112013009862B1 (pt) 2018-11-13
HUE046098T2 (hu) 2020-01-28
EP2632272B1 (en) 2019-08-21
US20140199269A1 (en) 2014-07-17
WO2012061082A2 (en) 2012-05-10
ES2746551T3 (es) 2020-03-06
IL225810A (en) 2016-07-31
CR20130184A (es) 2013-05-29
PL2632272T3 (pl) 2019-11-29
RU2013123483A (ru) 2014-12-10
CL2013001133A1 (es) 2013-11-22
CA2815789A1 (en) 2012-05-10
NZ609123A (en) 2014-08-29
EP2632272A4 (en) 2016-07-06
IL225810A0 (en) 2013-07-31
BR112013009862A2 (pt) 2016-07-05
ECSP13012590A (es) 2013-07-31
ZA201502551B (en) 2016-09-28
MA34676B1 (fr) 2013-11-02
ZA201303570B (en) 2016-05-25
CN103179862B (zh) 2015-09-16
AU2011323828A8 (en) 2015-03-05
RU2580105C2 (ru) 2016-04-10
KR101875591B1 (ko) 2018-07-06
US20120100236A1 (en) 2012-04-26
US10405555B2 (en) 2019-09-10
KR20140014075A (ko) 2014-02-05
AU2011323828B8 (en) 2015-03-05
CN105104433B (zh) 2018-04-13
CA2815789C (en) 2019-01-15
AU2011323828A1 (en) 2013-05-02
CN103179862A (zh) 2013-06-26
MX343738B (es) 2016-11-22
US8715754B2 (en) 2014-05-06
US20140303075A1 (en) 2014-10-09
US20160095323A1 (en) 2016-04-07
PE20140254A1 (es) 2014-03-29
US9187531B2 (en) 2015-11-17
AU2011323828B2 (en) 2015-02-12
EP2632272A2 (en) 2013-09-04
MX2013004683A (es) 2013-05-17

Similar Documents

Publication Publication Date Title
AR084725A1 (es) Composiciones bioactivas de chromobacterium y metabolitos
AR090316A1 (es) Cepa de flavobacterium plaguicida y composiciones bioactivas, metabolitos y usos
PE20141358A1 (es) Polimorfos de inhibidores de cinasas
CO6382126A2 (es) Compuestos heteroaromaticos fusionados y espirociclicos para el tratamiento de infecciones bacterianas
EA201692506A3 (ru) Ингибиторы репликации вирусов гриппа
NI201300130A (es) Composiciones que contienen, metodos que involucran, y usos de derivados de dolastatina unidos a aminoácidos no naturales
GT200800242A (es) Derivados biciclicos como inhibidores de cetp
BR112013021183A2 (pt) líquido de tratamento para jato de tinta e método de formação de imagem usando o líquido de tratamento
CO6382125A2 (es) Inhibidores de proteína quinasa
GT201300243A (es) Derivados de ácido 3-fenilpropiónico ramificados y su uso
BR112017009601A2 (pt) derivados de aminoácidos e seus usos
BR112012026767A2 (pt) composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, método para tratar ou previnir distúrbios, e, uso de um composto ou sal
CR20120626A (es) Formulaciones farmacéuticas que comprenden derivados de 1-(beta- D-glucopiranosil)-2-tienilmetil]benceno como inhibidores de los transportadores de glucosa dependientes de sodio (SGLT)
BR112012012903A2 (pt) compostos de espiropiperidina
AR086054A1 (es) Proceso para eliminar agua de las mezclas de alcohol
ECSP088876A (es) Formas de polimorfos de la (2s)-(4e)-n-metil-5-(3-isopropoxipiridin)il]-4-penten-2-amina para el tratamiento de desórdenes del sistema nervioso central
CL2010001642A1 (es) Composicion farmaceutica topica en gel que comprende a) 0,25 a 4,5% de un agente activo para el tratamiento de la queratosis actinica, b) un agente queratoliticamente activo, c) un formador de gel, d) un solvente organico, y menos de 5% en peso de agua; util para el tratamiento de la queratosis actinica.
AR067672A1 (es) Plantas que tienen rasgos mejorados relacionados con el rendimiento y un metodo para obtenerlas
BR112012009227A2 (pt) métodos e sistemas para purificar neurotoxina botulínica não complexada
CL2013002794A1 (es) Compuestos derivados de espiro(indazol-5,4’-piperidin) sustituidos, inhibidores de acetil-coa carboxilasa y su composicion farmaceutica, util para tratar una enfermedad, afeccion o trastorno modulado por la inhibicion de acetil-coa carboxilasa tal como diabetes, enfermedad de higado graso no alcoholico (hgna) o resistencia hepatica a insulina.
EA201591815A1 (ru) Бицикло [2.2.2] кислоты - модуляторы gpr120
SG10201807904RA (en) Mitochondria-Targeted Dicarbonyl Sequestering Compounds
MA33618B1 (fr) Agent thérapeutique destiné aux troubles de l'humeur
BR112018070363A2 (pt) derivados de tetraidroisoquinolina
MA53617A (fr) Composition pour inhiber l'activité de la trypsine, contenant, en tant que principe actif, une bactérie appartenant au genre paraprevotella

Legal Events

Date Code Title Description
FC Refusal