AR084536A1 - Agentes antimicrobianos - Google Patents
Agentes antimicrobianosInfo
- Publication number
- AR084536A1 AR084536A1 ARP110104879A ARP110104879A AR084536A1 AR 084536 A1 AR084536 A1 AR 084536A1 AR P110104879 A ARP110104879 A AR P110104879A AR P110104879 A ARP110104879 A AR P110104879A AR 084536 A1 AR084536 A1 AR 084536A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptides
- peptide
- seq
- amino acid
- fusion protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Una proteína de fusión que está compuesta por una enzima que puede degradar la pared celular de las bacterias Gram negativas y/o las bacterias Gram positivas y al menos dos extensiones peptídicas fusionadas en el extremo N o C de la enzima, donde las extensiones peptídicas son distinguibles y se seleccionan del grupo que consiste en los péptidos antipáticos sintéticos, los péptidos catiónicos sintéticos, los péptidos policatiónicos sintéticos los péptidos hidrofóbicos sintéticos y los péptidos antimicrobianos de origen natural, tales como los péptidos del sushi y las defensinas. Moléculas de ácidos nucleicos que codifican proteínas de fusión como la mencionada, vectores que comprenden dichas moléculas de ácidos nucleicos y células huésped que compren-den moléculas de ácidos nucleicos o vectores como los mencionados. Uso de dicha proteína de fusión como un medicamento, un medio de diagnóstico, una sustancia cosmética, un desinfectante o un aditivo para alimentos. Tratamiento o prevención de la contaminación provocada por las bacterias Gram negativas y/o las bacterias Gram positivas en un alimento, en un dispositivo para procesar alimentos, en una instalación para procesar alimentos, en una superficie que puede tomar contacto con un alimento, en un dispositivo médico, en una superficie en un hospital o en un quirófano.Reivindicación 6: La proteína de fusión de acuerdo con cualquiera de las reivindicaciones precedentes, caracterizada porque el péptido antimicrobiano tiene una secuencia de aminoácidos de acuerdo con SEQ ID Nº 44 a 62 y 78 a 98, el péptido del sushi tiene una secuencia de aminoácidos de acuerdo con SEQ ID Nº 63, el péptido hidrofóico tiene una secuencia de aminoácidos de acuerdo con SEQ ID Nº 65 y/o 66 y el péptido anfipático tiene una secuencia de aminoácidos de acuerdo con SEQ ID Nº 64, 68 y/o 69. Reivindicación 7: La proteína de fusión de acuerdo con cualquiera de las reivindicaciones precedentes, caracterizada porque dicha proteína de fusión tiene una secuencia de aminoácidos de acuerdo con SEQ ID Nº 70 a 77 y 127 a 147.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10196890A EP2468856A1 (en) | 2010-12-23 | 2010-12-23 | Antimicrobial Agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084536A1 true AR084536A1 (es) | 2013-05-22 |
Family
ID=44310766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104879A AR084536A1 (es) | 2010-12-23 | 2011-12-22 | Agentes antimicrobianos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130344055A1 (es) |
| EP (2) | EP2468856A1 (es) |
| JP (1) | JP2014507933A (es) |
| CN (1) | CN103403153A (es) |
| AR (1) | AR084536A1 (es) |
| AU (1) | AU2011347152B2 (es) |
| CA (1) | CA2822732C (es) |
| EA (1) | EA201370145A1 (es) |
| MX (1) | MX344257B (es) |
| TW (1) | TW201239095A (es) |
| WO (1) | WO2012085259A2 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9388400B2 (en) | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| WO2015070912A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| EP3105322B1 (en) | 2014-02-14 | 2018-12-12 | Lysando AG | Antimicrobial agents |
| WO2015155244A1 (en) * | 2014-04-08 | 2015-10-15 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| KR20180002618A (ko) * | 2015-03-23 | 2018-01-08 | 립타이드 바이오사이언스, 인코포레이티드 | 항균 펩티드 및 이의 사용방법 |
| BR112018005316A2 (pt) | 2015-09-17 | 2018-12-11 | Contrafect Corporation | ?uso de lisina para restabelecer/aumentar a atividade antibacteriana na presença de surfactante pulmonar de antibióticos inibidos desse modo? |
| WO2017203471A1 (en) | 2016-05-27 | 2017-11-30 | Sasinapas Co., Ltd. | Endolysin variant |
| AU2017360064C1 (en) * | 2016-11-18 | 2022-04-07 | Lysando Ag | New antimicrobial agents against staphylococcus aureus |
| WO2018185634A1 (en) * | 2017-04-03 | 2018-10-11 | Sasinapas Co., Ltd. | Engineered gram-negative endolysins |
| CN110256570B (zh) * | 2017-12-26 | 2021-01-05 | 杭州皇冠农业生物工程技术研究中心有限公司 | 一种重组融合抗菌肽及应用 |
| CN108251330B (zh) * | 2017-12-28 | 2021-03-23 | 江苏世邦生物工程科技有限公司 | 用于治理土壤污染的复合微生物菌剂及其制备方法和应用 |
| US10738093B2 (en) * | 2018-01-25 | 2020-08-11 | The Hong Kong University Of Science And Technology | Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining |
| CA3095484A1 (en) | 2018-03-29 | 2019-10-03 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| CN108410840A (zh) * | 2018-04-03 | 2018-08-17 | 大连理工大学 | 一种铜绿假单胞菌噬菌体内溶素及其编码基因与应用 |
| WO2019211643A1 (en) * | 2018-05-04 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating gram positive bacterial infection |
| KR20210014674A (ko) * | 2018-05-30 | 2021-02-09 | 뤼산도 아게 | 신규 항균성 융합 단백질 |
| CN112166190A (zh) * | 2018-05-30 | 2021-01-01 | 莱桑多公司 | 新抗微生物蛋白 |
| CA3110143A1 (en) * | 2018-08-28 | 2020-03-05 | Ultupharma Ab | Peptide compounds |
| GB201901364D0 (en) * | 2019-01-31 | 2019-03-20 | Axitan Ltd | Endolysins |
| US20220289794A1 (en) * | 2019-08-29 | 2022-09-15 | AJK Biopharmaceutical, LLC | Synthetic antimicrobial peptides |
| CA3171721A1 (en) | 2020-03-19 | 2021-09-23 | Fritz Eichenseher | A stabilized protein of interest |
| IT202000006481A1 (it) * | 2020-03-27 | 2021-09-27 | Sanidrink S R L | Condotti tubolari antimicrobici |
| IT202000006511A1 (it) * | 2020-03-27 | 2021-09-27 | Materias S R L | Peptidi antimicrobici |
| CN115397994B (zh) * | 2020-05-22 | 2023-03-28 | 株式会社莱森科技 | 新型多肽、融合多肽和包含其的抗革兰氏阴性菌的抗生素 |
| CN111955538B (zh) * | 2020-08-10 | 2022-09-30 | 浙江工商大学 | 一种大黄鱼保鲜剂及其使用方法 |
| CN112480230B (zh) * | 2020-11-30 | 2022-05-03 | 青岛农业大学 | 一种具有更好抗热功能的抗菌肽及其应用 |
| CN115323023B (zh) * | 2021-12-17 | 2024-05-03 | 河南牧业经济学院 | 一种治疗奶牛乳房炎药物的制备方法 |
| CN114651819A (zh) * | 2022-03-10 | 2022-06-24 | 上海芜玮建晖生物科技有限公司 | 一种基于海洋资源的有机消毒剂 |
| CN115433686B (zh) * | 2022-06-14 | 2024-03-22 | 天津市农业科学院 | 死亡素和斑点叉尾鮰β-防御素基因重组毕赤酵母的构建方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2962555B2 (ja) * | 1987-07-06 | 1999-10-12 | ヘリックス バイオメディックス，インコーポレイテッド | 溶菌ペプチドによる真核性病原体と新生物の抑制及び繊維芽細胞とリンパ球の刺激 |
| GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
| US7572602B1 (en) * | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) * | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| EP2318531A4 (en) * | 2008-07-24 | 2011-11-09 | Us Agriculture | TO RESISTANCE DEVELOPMENT REFRACTORY ANTIMICROBIAL ACTIVE SUBSTANCES |
| GB0815484D0 (en) * | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| US8383102B2 (en) * | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
| CA2764131C (en) * | 2009-06-26 | 2022-05-10 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Antimicrobial agents |
| KR101701890B1 (ko) * | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| AU2010288559B8 (en) * | 2009-08-24 | 2015-08-13 | Katholieke Universiteit Leuven, K.U. Leuven R&D | New endolysin OBPgpLYS |
| AU2011247584B2 (en) * | 2010-04-27 | 2016-01-14 | Lysando Ag | Method of reducing biofilms |
-
2010
- 2010-12-23 EP EP10196890A patent/EP2468856A1/en not_active Withdrawn
-
2011
- 2011-12-22 AR ARP110104879A patent/AR084536A1/es unknown
- 2011-12-23 US US13/997,058 patent/US20130344055A1/en not_active Abandoned
- 2011-12-23 JP JP2013545423A patent/JP2014507933A/ja active Pending
- 2011-12-23 MX MX2013007313A patent/MX344257B/es active IP Right Grant
- 2011-12-23 CA CA2822732A patent/CA2822732C/en active Active
- 2011-12-23 AU AU2011347152A patent/AU2011347152B2/en active Active
- 2011-12-23 CN CN201180068723XA patent/CN103403153A/zh active Pending
- 2011-12-23 EP EP11807927.6A patent/EP2655610B1/en active Active
- 2011-12-23 EA EA201370145A patent/EA201370145A1/ru unknown
- 2011-12-23 WO PCT/EP2011/073908 patent/WO2012085259A2/en active Application Filing
- 2011-12-23 TW TW100148225A patent/TW201239095A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201370145A1 (ru) | 2013-11-29 |
| WO2012085259A3 (en) | 2012-08-30 |
| AU2011347152A1 (en) | 2013-07-11 |
| AU2011347152B2 (en) | 2016-08-04 |
| TW201239095A (en) | 2012-10-01 |
| MX2013007313A (es) | 2013-10-25 |
| CA2822732C (en) | 2021-01-26 |
| US20130344055A1 (en) | 2013-12-26 |
| CA2822732A1 (en) | 2012-06-28 |
| MX344257B (es) | 2016-12-09 |
| EP2655610A2 (en) | 2013-10-30 |
| CN103403153A (zh) | 2013-11-20 |
| JP2014507933A (ja) | 2014-04-03 |
| EP2468856A1 (en) | 2012-06-27 |
| WO2012085259A2 (en) | 2012-06-28 |
| EP2655610B1 (en) | 2016-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |